Coupled Hemodynamics and Oxygen Diffusion in Abdominal Aortic Aneurysm: A Computational Sensitivity Study

Zakerzadeh, Rana; Cupac, Tanja; Dorfner, Nina; Guy, Alexander

doi:10.1007/s13239-020-00508-5

Cited by 6 publications

(9 citation statements)

References 41 publications

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“…To obtain a reasonable resolution of the solution based on the assumed value of the Reynolds number of 1,100, we used about 1.5 million tetrahedral elements to discretize the domain representing AAA. The mesh resolutions are identical to those reported in Zakerzadeh et al (2021) . The cited study also documents a systematic mesh convergence testing which is similar to that used in the computations of the current model.…”

Section: Methodsmentioning

confidence: 81%

“…The numerical methodology was validated using numerical research data of the literature, as described in Zakerzadeh et al ( Zakerzadeh et al, 2021 ). The blood flow with the velocity of

0.23 m/s matches physiological Reynolds numbers and represent the flow in the abdominal aorta under the resting condition ( Fraser et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

“…Our previous studies in ( Zakerzadeh et al, 2021 ) and ( Zakerzadeh et al, 2020 ) have thoroughly explored the effect of varying ILT biomechanical parameters such as permeability and oxygen diffusivity in an idealized AAA model. We extended the work by Vorp et al ( Vorp et al, 1998 ) in a parametric study and implemented a computational framework of coupled blood flow and oxygen transport for the purpose of assessing the effects of different geometrical and physical features including vasa vasorum flow (in the form of varying abluminal oxygen concentration boundary condition), kinematic diffusivities within the AAA tissue, and oxygen consumption in the arterial wall.…”

Section: Introductionmentioning

confidence: 99%

“…We extended the work by Vorp et al ( Vorp et al, 1998 ) in a parametric study and implemented a computational framework of coupled blood flow and oxygen transport for the purpose of assessing the effects of different geometrical and physical features including vasa vasorum flow (in the form of varying abluminal oxygen concentration boundary condition), kinematic diffusivities within the AAA tissue, and oxygen consumption in the arterial wall. Moreover, we also analyzed the effect of AAA geometry using four similar AAA models as in ( Vorp et al, 1998 ) and observed that geometry seems to have substantial influence on mass transport, and in particular, that ILT geometry can play a notable or negligible role on oxygen transport depending on its geometry ( Zakerzadeh et al, 2021 ). However, only four different geometries were used which is not enough to make a conclusion.…”

Section: Introductionmentioning

confidence: 99%

“…With the use of physiologically realistic biomechanical simulations of coupled computational fluid flow and mass transport in AAA, we simulate aortic wall oxygen transport and investigate the extent to which ILT attenuates oxygen concentration in the arterial wall. A three-dimensional computational model of AAA containing ILT is constructed which is similar to the previous research by authors presented in ( Zakerzadeh et al, 2021 ). The parametric space is composed of twenty-seven AAA models.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The Effects of Geometric Features of Intraluminal Thrombus on the Vessel Wall Oxygen Deprivation

Carbino

Guy

Durka

et al. 2022

Front. Bioeng. Biotechnol.

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The objective of this paper is to analyze the association of intraluminal thrombus (ILT) presence and morphology with oxygen transport in abdominal aortic aneurysms (AAA) and local hypoxia. The biomechanical role of the ILT layer in the evolution of the aneurysm is still not fully understood. ILT has been shown to create an inflammatory environment by reducing oxygen flux to the arterial wall and therefore decreasing its strength. It has been also hypothesized that the geometry of the ILT may further affect AAA rupture. However, no previous research has attempted to explore the effect of morphological features of ILT on oxygen distributions within the AAA, in a systematic manner. In this study, we perform a comprehensive analysis to investigate how physiologically meaningful variations in ILT geometric characteristics affect oxygen transport within an AAA. We simulate twenty-seven AAA models with variable ILT dimensions and investigate the extent to which ILT attenuates oxygen concentration in the arterial wall. Geometric variations studied include ILT thickness and ILT length, as well as the bulge diameter of the aneurysm which is related to ILT curvature. Computer simulations of coupled fluid flow-mass transport between arterial wall, ILT, and blood are solved and spatial variations of oxygen concentrations within the ILT and wall are obtained. The comparison of the results for all twenty-seven simulations supports the hypothesis that the presence of ILT in AAA correlates to significantly impaired oxygen transport to the aneurysmal wall. Mainly, we observed that ILT thickness and length are the parameters that influence decreased oxygen flow and concentration values the most, and thick thrombi exacerbate hypoxic conditions in the arterial wall, which may contribute to increased tissue degradation. Conversely, we observed that the arterial wall oxygen concentration is nearly independent of the AAA bulge diameter. This confirms that consideration of ILT size and anatomy is crucial in the analysis of AAA development.

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Section: Methodsmentioning

confidence: 81%

“…The numerical methodology was validated using numerical research data of the literature, as described in Zakerzadeh et al ( Zakerzadeh et al, 2021 ). The blood flow with the velocity of

0.23 m/s matches physiological Reynolds numbers and represent the flow in the abdominal aorta under the resting condition ( Fraser et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%