Coupling Genetic Addiction Risk Score (GARS) and Pro Dopamine Regulation (KB220) to Combat Substance Use Disorder (SUD)

Blum, Kenneth; Madigan, Margaret; Fried, Lyle; Braverman, Eric R.; Giordano, John; Badgaiyan, Rajendra D.

doi:10.19080/gjarm.2017.01.555556

Cited by 59 publications

(14 citation statements)

References 48 publications

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“…An extensive dossier of clinical and animal research indicates that in addition to promoting manageable reduction in addiction, obsession, compulsion, impulsion and an expansive range of aberrant personality disorders, achieving dopamine homeostasis with a number of epigenetic anti-dopaminylation insults possibly including a DNAdesigned precision nutrigenomic intervention (KB220Z PBM) provides evidenced based systemic benefits including: restoring optimal aerobic metabolism in the brain by improving Blood Oxygen Level Dependent signaling and functioning; reducing anaerobic pathologies and the generation of Reactive Oxygen Species; inducing neurotransmitter interconnectivity (aka 'crosstalk'); promoting restful sleep and waking accompanied by an increase in happy dreams; improving gut-brain signaling; reducing gastrointestinal inflammation and promoting GI tract functional competence; improving appetite regulation and food intake; improving vision and circadian rhythm regulation; and, importantly, reducing the effects of stress and improving immune competence [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]30,33,34,52,53,58,60,63,64] This treatise expands our understanding of the health benefits of achieving dopamine homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…Relevant genotype-phenotype relationships can be characterized using the Genetic Addiction Risk Score (GARS ® ) [12]. Based on GARS values, dopamine homeostasis may be achieved via customization of neuro-nutrient supplementation with particular emphasis on enhancement of immunological function [13][14][15][16]. Precision Behavioral Management (PBM), and putative pro-dopamine regulation should be accompanied by interventions like mindfulness and trauma therapy.…”

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confidence: 99%

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Molecular neuro-biological and systemic health benefits of achieving dopamine homeostasis in the face of a catastrophic pandemic (COVID- 19): A mechanistic exploration

Downs¹,

Blum²,

Bagchi³

et al. 2020

J Syst Integr Neurosci

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In the face of the global pandemic of COVID 19, approaching 1.75 Million infected worldwide (4/12/2020) and associated mortality (over 108, 000 as of 4/12/2020) as well-as other catastrophic events including the opioid crisis, a focus on brain health seems prudent [1] (https://www.coronavirus.gov). This manuscript reports on the systemic benefits of restoring and achieving dopamine homeostasis to reverse and normalize thoughts and behaviors of Reward Deficiency Syndrome (RDS) dysfunctional conditions and their effects on behavioral physiology; function of reward genes; and focuses on digestive, immune, eye health, and the constellation of symptomatic behaviors. The role of nutrigenomic interventions on restoring normal brain functions and its benefits on these systems will be discussed. We demonstrate that modulation of dopamine homeostasis using nutrigenomic dopamine agonists, instead of pharmaceutical interventions, is achievable. The allied interlinking with diverse chronic diseases and disorders, roles of free radicals and incidence of anaerobic events have been extensively highlighted. In conjunction, the role of dopamine in aspects of sleep, rapid eye movement and waking are extensively discussed. The integral aspects of food indulgence, the influence of taste sensations, and gut-brain signaling are also discussed along with a special emphasis on ocular health. The detailed mechanistic insight of dopamine, immune competence and the allied aspects of autoimmune disorders are also highlighted. Finally, the integration of dopamine homeostasis utilizing a patented gene test and a research-validated nutrigenomic intervention are presented. Overall, a cutting-edge nutrigenomic intervention could prove to be a technological paradigm shift in our understanding of the extent to which achieving dopamine homeostasis will benefit overall health.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Molecular neuro-biological and systemic health benefits of achieving dopamine homeostasis in the face of a catastrophic pandemic (COVID- 19): A mechanistic exploration

Downs¹,

Blum²,

Bagchi³

et al. 2020

J Syst Integr Neurosci

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“…RDSS include methods for achieving dopamine homeostasis [22]. RDSS also offers viable application for rejuvenating a brain damaged by toxicity, in neuro-nutrient supplements [23] which provide the amino acid building blocks for proper brain function, and pro-dopamine regulator therapy [24] to combat SUD. After identifying these individuals, and their RDS phenotype, special RDS and RDSS psychoeducation can be provided, as well as tailored individual treatment recovery plans for Reward Deficiency Syndrome [12], to help achieve dopamine homeostasis, within the typical traditional "Treatment as Usual" (TAU), 12 step oriented treatment facility program [25].…”

Section: Discussion Of Reward Deficiency System Solutionsmentioning

confidence: 99%

Reward Deficiency Syndrome Solution Focused Brief Therapy to Begin Integrating the Sciences of Addiction & Reward Deficiency Syndrome (RDS)

Gilley¹

2019

J Reward Defic Syndr Addict Sci

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Reward Deficiency Syndrome Solution Focused Brief Therapy (RDS-SFBT), provided in both individual and group therapy formats, in the practice of Addiction Recovery Treatment, will help the client understand the importance of the challenge to achieve dopamine homeostasis in the recovery process. RDS-SFBT introduces new Reward Deficiency Syndrome concepts and solutions to the practitioner-client world, helping to bridge the gap between the worlds of research and therapeutic practice [1]. Newly created RDS-SFBT will bring awareness of the advancements of cutting-edge global Reward Deficiency Syndrome research efforts [2], and expands the resource application available to the consumer.

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“…Psychology Research and Behavior Management 2021:14 2120 positively associated with sensation seeking and impulsivity while reward deficiency was under control. 55 We are aware that when evaluating RDS in AfricanAmericans or other cultures and geographies that differ from the Hungarian group, a culturally appropriate RDS questionnaire needs to be developed and validated for the RDS component to be informative.…”

Section: Dovepressmentioning

confidence: 99%

A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing “Precision Behavioral Management”

Blum¹,

Steinberg²,

Gondré–Lewis³

et al. 2021

PRBM

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This is a review of research on “Precision Behavioral Management” of substance use disorder (SUD). America is experiencing a high prevalence of substance use disorder, primarily involving legal and illegal opioid use. A 3000% increase in treatment for substance abuse has occurred between 2000 and 2016. Unfortunately, present day treatment of opioid abuse involves providing replacement therapy with powerful opioids to, at best, induce harm reduction, not prophylaxis. These interventions do not enhance gene expression and restore the balance of the brain reward system’s neurotransmitters. We are proposing a generalized approach called “Precision Behavioral Management”. This approach includes 1) using the Genetic Addiction Risk Severity (GARS, a 10 candidate polymorphic gene panel shown to predict ASI-alcohol and drug severity) to assess early pre-disposition to substance use disorder; 2) using a validated reward deficiency syndrome (RDS) questionnaire; 3) utilization of the Comprehensive Analysis of Reported Drugs (CARD™) to assess treatment compliance and abstinence from illicit drugs during treatment, and, importantly; 4) utilization of a “Pro-dopamine regulator (KB220)” (via IV or oral [KB220Z] delivery systems) to optimize gene expression, restore the balance of the Brain Reward Cascade’s neurotransmitter systems and prevent relapse by induction of dopamine homeostasis, and; 5) utilization of targeted DNA polymorphic reward genes to direct mRNA genetic expression profiling during the treatment process. Incorporation of these events can be applied to not only the under-considered African-American RDS community, but all victims of RDS, as a demonstration of a paradigm shift that uniquely provides a novel putative “standard of care” based on DNA guided precision nutrition therapy to induce “dopamine homeostasis” and rebalance neurotransmitters in the Brain Reward Cascade. We are also developing a Reward Deficiency Syndrome Diagnostic Criteria (RDSDC) to assist in potential tertiary treatment.

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Coupling Genetic Addiction Risk Score (GARS) and Pro Dopamine Regulation (KB220) to Combat Substance Use Disorder (SUD)

Cited by 59 publications

References 48 publications

Molecular neuro-biological and systemic health benefits of achieving dopamine homeostasis in the face of a catastrophic pandemic (COVID- 19): A mechanistic exploration

Molecular neuro-biological and systemic health benefits of achieving dopamine homeostasis in the face of a catastrophic pandemic (COVID- 19): A mechanistic exploration

Reward Deficiency Syndrome Solution Focused Brief Therapy to Begin Integrating the Sciences of Addiction & Reward Deficiency Syndrome (RDS)

A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing “Precision Behavioral Management”

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