Coupling of cerebral blood flow and functional connectivity is decreased in healthy aging

Galiano, Alvaro; Mengual, Elisa; Eulate, Reyes García de; Galdeano, Iñigo; Vidorreta, Marta; Recio, Miriam; Riverol, Mario; Zubieta, J. L.; Fernández‐Seara, María A.

doi:10.1007/s11682-019-00157-w

Cited by 35 publications

(23 citation statements)

References 79 publications

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“…Liu et al, 2012;Parkes et al, 2004). Group differences as a function of age based on whole-brain voxel-wise analysis at corrected threshold revealed regions of greater resting-state CBF in older adults, consistent with prior studies that reported greater regional CBF in older, compared to younger, adults in temporal, parietal, occipital, and subcortical regions (Galiano et al, 2019;Preibisch et al, 2011).…”

Section: Main Effect Of Agesupporting

confidence: 80%

Individual Differences in Cerebral Perfusion as a Function of Age and Loneliness

Chen

Wengler

et al. 2021

Experimental Aging Research

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Loneliness is defined as the subjective feeling that one's social needs are not satisfied by both quantity and quality of one's social relationships. Loneliness has been linked to a broad range of adverse physical and mental health consequences. There is an interest in identifying the neural and molecular processes by which loneliness adversely affects health. Prior imaging studies reported divergent networks involved in cognitive, emotional, and social processes associated with loneliness. Although loneliness is common among both younger and older adults, it is experienced differently across the lifespan and has different antecedents and consequences. The current study measured regional cerebral blood flow (CBF) using pulsed arterial spin labeling imaging. Forty-five older (M age = 63.4) and forty-four younger adults (M age = 20.9) with comparable degrees of loneliness were included. Wholebrain voxel-wise analysis revealed a main effect of age (in superior temporal and supramarginal gyri), but no main effect of loneliness. Furthermore, the age effect was only observed among people who reported higher level of loneliness. These regions have previously been implicated in social-and attention-related functions. The moderation of loneliness on age and regional CBF suggests that younger and older individuals present differential neural manifestations in response to loneliness, even with comparable levels of loneliness.

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Section: Main Effect Of Agesupporting

confidence: 80%

Individual Differences in Cerebral Perfusion as a Function of Age and Loneliness

Chen

Wengler

et al. 2021

Experimental Aging Research

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“…These patterns of effects have been associated with a progressive decrease in specialization of functional systems with potential detriment to information processing in older age groups. Age-related alterations in rsFC have been associated with a number of factors, including amyloid-b deposition (Ferreira and Busatto, 2013), neurovascular dysregulation (Galiano et al, 2020), and integrity across gray and white matter (Vidal-Piñeiro et al, 2014). Our findings suggest that sulcal pattern variability interacts with age-associated effects in shaping the brain's interregional connectivity shedding light on the long-term contribution of longitudinally stable neurodevelopmental markers on resting-state networks.…”

Section: Discussionmentioning

confidence: 70%

Sulcal Pattern Variability and Dorsal Anterior Cingulate Cortex Functional Connectivity Across Adult Age

et al. 2020

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Background: The dorsal anterior cingulate cortex (dACC) is a key network hub for cognitive control and environmental adaptation. Previous studies have shown that task-based functional activity in this area is constrained by individual differences in sulcal pattern, a morphologic feature of cortex anatomy determined during fetal life and stable throughout development. Methods: By using anatomical magnetic resonance imaging and seed-based resting-state functional connectivity (rsFC), we explored the influence of sulcal pattern variability on the functional architecture of the dACC in a sample of healthy adults aged 20-80 years (n = 173). Results: Overall, rsFC was associated with individual differences in sulcal pattern. Furthermore, rsFC was modulated by the age-sulcal pattern interaction. Conclusion: Our results suggest a relationship between brain structure and function that partly traces back to early stages of brain development. The modulation of rsFC by the age-sulcal pattern interaction indicates that the effects of sulcal pattern variability on the functional architecture of the dACC may change over adulthood, with potential repercussions for brain network efficiency and cognitive function in aging.

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“…Several studies have also found evidence of decreased cerebral perfusion with aging, using different imaging techniques (Chen et al, 2011;Liu et al, 2011). Because aging causes general brain atrophy and cortical thinning, which may increase the partial volume effects (Slosman et al, 2001), and may disrupt the relationship between CBF and intrinsic functional connectivity via neurovascular dysregulation (Galiano et al, 2019). In terms of smoking, previous studies have shown smoking habit was associated with cognitive decline, lower cortical volumes and higher WMH volumes (Cox et al, 2019;Turon et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden

Qiu

et al. 2020

Front. Aging Neurosci.

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Background: Cerebral small vessel disease (CSVD) is a common age-related vascular disease of the brain associated with slowly accumulating tissue damage. At present, total CSVD burden score is a commonly used method to evaluate the severity of the disease. Purpose: To observe whether global and regional cerebral perfusion is related to total CSVD score and to explore global and regional cerebral blood flow (CBF) changes in patients with different degrees of CSVD. Methods: We collected 130 subjects with different total burden score of CSVD (0 point: 33 subjects, 1 point: 39 subjects, 2 points: 24 subjects, 3 points: 24 subjects, 4 points: 10 subjects). Total CSVD burden score was evaluated by clinically routine sequences (T2WI, T2-FLAIR, T1WI, DWI, and SWAN sequence). Global and regional CBF were calculated and correlation analysis was used to investigate the relationship between total CSVD score and CBF of the whole brain and several brain regions. Results: The analysis results showed that there was a negative correlation between total CSVD burden score and global CBF (r = −0.33, p = 0.001). Total CSVD burden score also had moderately negative correlations with CBF of almost all the brain regions. Conclusion: CSVD is a disease that affects the whole brain. With the increase of total CSVD burden score, the global and regional CBF decreased. The CSVD total burden score could be used to evaluate the overall condition of brain perfusion.

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Coupling of cerebral blood flow and functional connectivity is decreased in healthy aging

Cited by 35 publications

References 79 publications

Individual Differences in Cerebral Perfusion as a Function of Age and Loneliness

Individual Differences in Cerebral Perfusion as a Function of Age and Loneliness

Sulcal Pattern Variability and Dorsal Anterior Cingulate Cortex Functional Connectivity Across Adult Age

Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden

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