Couroupita guianensis: Evaluation of its anxiolytic and antidepressant activity in mice

The protective effect of L. siceraria against depression using behavioural despair animal models

“…The immobility is noted as a measure of antidepressant action also swimming behaviour corresponds to the behavioural despair as seen in human depression. 13 It was reported that the major depressive disorder involves disturbances of life style, emotional changes, autonomic and endocrine functions affecting about 20% of population. 14 In phytochemical study authors observed the presence of flavonoids (flavonol glycosides) in L. siceraria fruit extract.…”

“…Thus, the flavonoids may be responsible for the said antidepressant activity of Lagenaria siceraria. 13,17 Remarkably, these models detect the anti-immobility effects of wide array of antidepressants, including tricyclic antidepressants (TCA), selective serotonin reuptake inhibitors (SSRI), monoamine oxidase inhibitors (MAOI) and even atypical antidepressants. Thus, the activity of ethanolic extract of the fruit of Lagenaria siceraria could involve one of mechanism of established agents as described above and further scientific research should be under taken towards this dimension.…”

Antihyperglycemic Potential of Ethanolic Extract of Couroupita guianensis on Streptozocin Induced Experimental Diabetic Rat Model

“…Although there exists a substantial number of reports claiming the hypo/anti-hyperglycemic effect of Couroupita guianensis leaves and flowers [7,8]. It is also reported to have antioxidant activity [9,10], analgesic and anti-inflammatory activity [5,11], anti-depressant and anti-stress activity [10,12], antimicrobial activity [13,14,15,16,17], immunomodulatory activity [18,19].…”