The study proves that the crude methanolic extract of Enhydra fluctuans Lour. has significant antioxidant, anthelmintic and thrombolytic activity containing wide range of phytochemicals.

Background: The present study was performed to investigate the effect of oral feeding of 50% ethanolic (v/v) extract of Couroupita guianensis leaves in streptozotocin induced type 2 diabetic model rats for the possible anti-diabetic mechanism.

Phytochemical screening and antidiabetic effects of fruit rind of Momordica dioica roxb. on streptozocin induced type 2 diabetic rats, HELIYON, https://doi.org/10.1016/j.heliyon.2022.e08771. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Amaranthus viridis is an ecumenical species in the botanical family of Amaranthaceae, which has been traditionally used to treat several skin diseases along with some antilipidemic activities. The present study was carried out to investigate the anti-hyperglycemic effect of 75% ethanolic extract of A. viridis in Neonatal streptozotocin (N-STZ) induced rats' hemi-diaphragm, including screening for secondary plant metabolites. Qualitative phytochemical studies were done by various conventional methods for the possible secondary metabolites. For antidiabetic assay via hemi-diaphragm, Long-Evan rats were used in the study. Type 2 diabetes was induced by a single ip injection of streptozotocin to 48 h old pups (N-STZ) and after 3 months, rats were confirmed by an oral glucose tolerance test and further selected for the experiment. Studies to evaluate the glucose utilization capacity of A. viridis in isolated rat hemi-diaphragm were done. The data were analyzed by appropriate statistical analysis. In vitro glucose uptake by hemi-diaphragm study showed glucose uptake increased significantly in left diaphragm of type 2 diabetes mellitus with insulin alone treated and A. viridis alone treated group, where A. viridis alone treated group showed very highly significance (p=0.000). Treatment with both insulin and A. viridis increased the glucose uptake also very significantly (p=0.004). A. viridis extract acted more significantly compared to insulin in T2DM rats. In the normal rats at left hemi diaphragm, A. viridis extract also increased glucose uptake more significantly (p=0.009) compared to insulin (p=0.013). At the right diaphragm, glucose uptake increased in all treated groups compared to control group but not significantly. This plant may contain potential anti-hyperglycemic agents which possibly act through some extra pancreatic mechanism that include glucose uptake by diaphragm and increased glycogenesis by liver.