Antihyperglycemic Potential of Ethanolic Extract of Couroupita guianensis on Streptozocin Induced Experimental Diabetic Rat Model

Hassan, Md. Mynul; Islam, Md. Mahmodul; Uddin, Shihab; Bhowmik, Arijit; Rokeya, Begum

doi:10.9734/ajrimps/2018/44332

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…In the present study, the intercellular pathway was predominantly facilitated by the lipid-based IL [EDMPC][Lin] of the PCNC owing to the lipophilic and surface-active nature of the IL. The mechanism was further evaluated by FTIR analysis of the intercellular lipids and fatty acids in the SC, such as cholesterol and ceramides, which predominantly hinder drug diffusion. , We evaluated the effect of the PCNC on the (symmetrical and asymmetrical) alkyl chains of the structural lipids in the SC. The peaks at 2850 and 2920 cm –1 can be attributed to the symmetrical (νCH 2 _sym) (Figure B) and asymmetrical (νCH 2 _asym) (Figure C) CH 2 alkyl chain vibration modes of the lipids, respectively .…”

Section: Resultsmentioning

confidence: 99%

Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy

Uddin

Islam

Moshikur

et al. 2022

ACS Appl. Bio Mater.

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Transdermal drug delivery systems (TDDSs) may be useful for preventing various diseases including cancer. However, the stratum corneum (SC) inhibits the permeation of foreign particles into the skin. To obtain an effective TDDS, we developed a protein-containing nanocarrier (PCNC) comprising an antigenic protein (ovalbumin/OVA) stabilized by a combination of surfactants, i.e., a lipid-based surface-active ionic liquid and Tween-80. The PCNC was lyophilized to remove water and cyclohexane and then dispersed in isopropyl myristate. It is biocompatible both in vitro and in vivo, and is suitable for use in a therapeutic TDDS. The skin permeability of the PCNC was significantly (p < 0.0001) enhanced, and the transdermal distribution and transdermal flux of the OVA delivery system were 25 and 28 times greater, respectively, than those of its aqueous formulation. The PCNC disrupted the order of lipid orientation in the skin’s SC and increased intercellular protein delivery. It demonstrated effective antitumor activity, drastically (p < 0.001) suppressed tumor growth, increased mouse survival rates, and significantly (p < 0.001) stimulated the OVA-specific tumor immune response. The PCNC also increased the number of cytotoxic T cells expressing CD8 antibodies on their surfaces (CD8 + T-cells) in the tumor microenvironment. These findings suggest that PCNCs may be promising biocompatible carriers for transdermal antigenic protein delivery in tumor immunotherapy.

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Section: Resultsmentioning

confidence: 99%

Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy

Uddin

Islam

Moshikur

et al. 2022

ACS Appl. Bio Mater.

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“…The Glucose Oxidase (GOD-PAP) method was used to measure the serum glucose and quantified by using a micro-plate reader (Bio-Tec, ELISA) [1]. The Enzymatic colorimetric method autoanalyzer (Randox Laboratories Ltd., UK) was used to measure total serum cholesterol (TC) (Cholesterol Oxidase/Peroxidase, CHOD-PAP), triglycerides (TG) (GPO PAP), and serum lipid (HDL-C) respectively [1]. Serum insulin was measured by using the enzyme-linked immunosorbent assay (ELISA) method according to the manufacturer's instructions (Crystal Chem Inc., Downers Grove, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Diabetics causes several complications, including metabolic disorders of carbohydrate, lipid, and protein in the body, as well as vasculopathies. [1,2]. The predominance of diabetes is higher in men than women [3].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and antidiabetic effects of fruit rind of Momordica dioica roxb. on streptozocin induced type 2 diabetic rats

Hassan

Uddin

Bhowmik

et al. 2022

Heliyon

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Phytochemical screening and antidiabetic effects of fruit rind of Momordica dioica roxb. on streptozocin induced type 2 diabetic rats, HELIYON, https://doi.org/10.1016/j.heliyon.2022.e08771. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…A single intraperitoneal injection of Streptozotocin (STZ) in citrate buffer (10 ml) at a concentration of 90 mg/kg body weight was used for producing type-2 diabetes in rat pups (48 h old, average weight 7 g) according to Hassan et al, 2018;Hasan et al,2019. The rat pups were administered an intraperitoneal injection of STZ solution with a dosage of 10 µl /g body weight.…”

Section: Preparation Of Type-2 Diabetic Model Ratsmentioning

confidence: 99%

Effects of Probiotic Supplemented Yogurt on Neonatal Streptozotocin-Induced Type-2 Diabetic Rats

et al. 2022

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Probiotics can be considered as biological agents that modify the intestinal microbiota as well as show several health benefits. The purpose of this study was to explore the effects of probiotics in neonatal STZ-induced type-2 diabetic rats. Following the biochemical analysis of probiotic bacteria, yogurt was prepared using cow milk and used to feed the experimental rats. Probiotic yogurt was supplemented to three rat groups, each with six rats, and the doses were 2 g in PYT1, 4 g in PYT2 and 6 g in PYT3 for 21 days. Fasting serum glucose, serum insulin, lipid profiles and liver glycogen levels were measured to investigate the probiotic effects on type 2 diabetic rats. It was observed that fasting serum glucose levels were significantly lower in case of PYT3 group (p<0.05) whereas a significant (p<0.05) upsurge of serum insulin levels was detected in PYT2 rat group. A significant (p<0.05) decrease in LDL level in PYT2 group and significantly (p<0.05) increased level of HDL was detected in PYT1 and PYT2 rat groups. However, there were no significant differences regarding triglyceride as well as total cholesterol levels among three probiotic yogurt supplemented rat groups. Hepatic glycogen content was 34.5%, 30.9% and 39.1% among the probiotic yogurt feed groups viz. PYT1, PYT2 and PYT3, respectively. Findings of this research suggest that application of probiotic yogurt can help to manage type-2 diabetes. Further study on clinical trial would be worthy to investigate for probiotic-based product improvement for treatment of type-2 diabetic patients.

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Antihyperglycemic Potential of Ethanolic Extract of Couroupita guianensis on Streptozocin Induced Experimental Diabetic Rat Model

Abstract: Background: The present study was performed to investigate the effect of oral feeding of 50% ethanolic (v/v) extract of Couroupita guianensis leaves in streptozotocin induced type 2 diabetic model rats for the possible anti-diabetic mechanism.

Cited by 4 publications

References 9 publications

Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy

Transdermal Delivery of Antigenic Protein Using Ionic Liquid-Based Nanocarriers for Tumor Immunotherapy

Phytochemical screening and antidiabetic effects of fruit rind of Momordica dioica roxb. on streptozocin induced type 2 diabetic rats

Effects of Probiotic Supplemented Yogurt on Neonatal Streptozotocin-Induced Type-2 Diabetic Rats

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