COVID-19-associated acute kidney injury patients treated with renal replacement therapy in the intensive care unit: A multicenter study in São Paulo, Brazil

Samaan, Farid; Paula, Elisa Carneiro de; Souza, Fabrizzio Batista Guimarães de Lima; Mendes, Luiz Fernando Cardoso; Rossi, Paula Regina Gan; Freitas, Rafaela Andrade Penalva; Nakagawa, Fernando Takahashi; Maciel, Alexandre Toledo; Aranha, Sylvia Carolina; Osawa, E; Konigsfeld, Henrique Pinheiro; Silva, Riberto Garcia da; Souza, Ricardo Barbosa Cintra de; Coutinho, Saurus Mayer; Vieira, Tales Dantas; Thomaz, Karina De Bonis; Flato, Elias Marcos Silva; Silva, Renata Cristina da; Andrade, Lucas Vicente; Badaoui, Muna; Badaoui, Eduardo Pogetti; Góes, Miguel Ângelo; Amaral, Sergio Henrique do; Cunha, Karlla; Muniz, Inês Marin; Sampaio, Jacqueline Siqueira; Durão, Marcelino de Souza; Zanetta, Dirce Maria Trevisan; Burdmann, Emmanuel A.

doi:10.1371/journal.pone.0261958

Cited by 16 publications

(36 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, patients who were ventilated (either non-invasively or invasively) also had a poorer outcome. These findings are consistent with observations from other parts of the world [24][25][26][27][28].…”

Section: Factors Influencing Outcomesupporting

confidence: 93%

Acute kidney injury in critically ill COVID-19 infected patients requiring dialysis: experience from India and Pakistan

Anandh

Noorin²,

Kazmi

et al. 2022

BMC Nephrol

View full text Add to dashboard Cite

Background Acute kidney injury (AKI) was common in the first two waves of the SARS-COV-2 pandemic in critically ill patients. A high percentage of these patients required renal replacement therapy and died in the hospital. Methods The present study examines the clinical presentation, laboratory parameters and therapeutic interventions in critically ill patients with AKI admitted to the ICU in two centres, one each in India and Pakistan. Patient and outcome details of all critically ill COVID 19 patients admitted to the ICU requiring renal replacement therapy were collected. Data was analysed to detect patient variables associated with mortality. Results A total of 1,714 critically ill patients were admitted to the ICUs of the two centres. Of these 393 (22.9%) had severe acute kidney injury (AKIN stage 3) requiring dialysis. Of them, 60.5% were men and the mean (± SD) age was 58.78 (± 14.4) years. At the time of initiation of dialysis, 346 patients (88%) were oligo-anuric. The most frequent dialysis modality in these patients was intermittent hemodialysis (48.1%) followed by slow low efficiency dialysis (44.5%). Two hundred and six (52.4%) patients died. The mortality was higher among the Indian cohort (68.1%) than the Pakistani cohort (43.4%). Older age (age > 50 years), low serum albumin altered sensorium, need for slower forms of renal replacement therapy and ventilatory support were independently associated with mortality. Conclusion There was a very high mortality in patients with COVID-19 associated AKI undergoing RRT in the ICUs in this cohort from the Indian sub-continent.

show abstract

Section: Factors Influencing Outcomesupporting

confidence: 93%

Acute kidney injury in critically ill COVID-19 infected patients requiring dialysis: experience from India and Pakistan

Anandh

Noorin²,

Kazmi

et al. 2022

BMC Nephrol

View full text Add to dashboard Cite

show abstract

“…The present study was conducted during the pandemic of SARS-CoV-2, a pathogen with a high incidence of kidney involvement, which increased the prevalence and lethality of patients who were on RRT due to AKI [ 19 ]. Indeed, the impact of AKI on the mortality of patients with and without COVID-19 has been recently addressed in Brazilian multicenter studies [ 20–22 ].…”

Section: Discussionmentioning

confidence: 99%

Medical students’ and health professionals’ knowledge regarding acute kidney injury: a cross-sectional study in the city of São Paulo, Brazil

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Acute kidney injury (AKI) is a worldwide public health problem and is often treated by non-nephrologists. The objective of this study was to evaluate the knowledge of non-nephrologists, undergraduate medical students and health professionals regarding AKI. Methods An unsupervised and closed-response electronic questionnaire was sent to sixth-year medical students and non-nephrologist health professionals working in the city of São Paulo, Brazil. Results A total of 424 responses were returned from 650 invitations (40.1% males, 39.2% physicians, 34.0% senior medical students or resident physicians, 16.3% nurses and 10.6% pharmacists). The knowledge of medical students and health professionals about the prevalence and lethality of AKI in hospitals ranged from 40.8% to 59.2%. The most recognized susceptibilities and risk factors for AKI were sepsis/septic shock (95.0%) and diabetes mellitus (91.3%); the less-recognized susceptibilities and risk factors were exposure to gadolinium-based contrast (23.3%) and chronic liver disease (55.7%). The study participants’ rate of knowledge regarding the diagnosis of AKI was 50.9–73.6%, and their rate of knowledge regarding the criteria of increased serum creatinine and reduced urine volume was 52.6%. The most-recognized nephrotoxic medications were vancomycin (82.3%) and diclofenac (80.4%), and the least-recognized were acyclovir (34.0%) and cotrimoxazole (30.4%). The indications for emergency renal replacement therapy that were recognized by the study respondents were metabolic acidosis (82.3%), uremic syndrome (81.6%), hyperkalemia unresponsive to clinical treatment (78.1%) and acute pulmonary edema (71.6%). Conclusion The study showed knowledge gaps that can impact patient care and can be used to guide professional training programs.

show abstract

“… 37 Physical health has a significant impact on the risk of COVID-19 infection and disease outcome, whereas mental health has a negligible impact on these. 44–46 …”

Section: Discussionmentioning

confidence: 99%

Group-based trajectory modeling to identify health beliefs of COVID-19 vaccination and its predictors: A cohort study in China

Kang

Wang²,

Xing

et al. 2022

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Objectives This study aimed to characterize distinct patterns of change in health beliefs and their dimensions of COVID-19 vaccination and to evaluate the predictors of various trajectory groups. Methods A total of 1129 participants who completed two doses of COVID-19 vaccines in China were included in this prospective study. Participants’ characteristics and health beliefs regarding COVID-19 vaccination were collected before and after the two doses of COVID-19 vaccination. A group-based trajectory model was used to identify the distinct longitudinal patterns of health beliefs and their dimensions. A multinomial logistic regression model was conducted to determine the predictors of different trajectory groups. Results The group-based trajectory model identified two to four distinct patterns of global health beliefs and their domains, namely, very low-stable (16.1%), low-stable (30.2%), medium-stable (45.6%), and high-stable (8.1%) trajectories for global health beliefs. And the five domains of health beliefs showed two or three trajectory stable progression, which were similar to the global health beliefs trajectories. Sex, occupation post, adverse reactions foreboding, and quality of life were associated with the trajectory of global health beliefs or at least one domain of health beliefs. Conclusions During the study, individuals’ health beliefs about COVID-19 vaccination were stable without the interference of external factors. Based on the impact of sex, occupation post, adverse reactions foreboding, and quality of life on individuals’ health beliefs, personalized interventions can be developed to improve public health beliefs about COVID-19 vaccination and reduce vaccination hesitancy.

show abstract

COVID-19-associated acute kidney injury patients treated with renal replacement therapy in the intensive care unit: A multicenter study in São Paulo, Brazil

Cited by 16 publications

References 35 publications

Acute kidney injury in critically ill COVID-19 infected patients requiring dialysis: experience from India and Pakistan

Acute kidney injury in critically ill COVID-19 infected patients requiring dialysis: experience from India and Pakistan

Medical students’ and health professionals’ knowledge regarding acute kidney injury: a cross-sectional study in the city of São Paulo, Brazil

Group-based trajectory modeling to identify health beliefs of COVID-19 vaccination and its predictors: A cohort study in China

Contact Info

Product

Resources

About