COVID-19-associated myoclonus in a series of five critically ill patients

Grieb, Alexander; Seitz, Tamara; Kitzberger, Reinhard; Schmidbauer, Manfred; Hoepler, Wolfgang; Baumgartner, Sebastian; Traugott, Marianna; Pawelka, Erich; Karolyi, Mario; Strasser, Georg; Knibbe, Karolina; Laferl, Hermann; Zoufaly, Alexander; Wenisch, Christoph; Neuhold, Stephanie

doi:10.1007/s00508-021-01890-3

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…A total of 105 patients had been described in the medical literature up to the end of 2022. Forty-three of these 105 cases had a severe SARS-CoV-2 infection and required hospitalization in the ICU [48][49][50][51][52][53][54][55][56]. As the movement disorder could be a possible complication (hypoxia, medications) they were not included into analysis.…”

Section: Ataxia/myoclonus/opsoclonus Syndromementioning

confidence: 99%

Hyperkinetic movement disorders following SARS-CoV-2 infection and vaccination — an update

Przytuła¹,

Sławek

2023

Neurol Neurochir Pol.

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The aim of this review was to summarise current knowledge regarding hyperkinetic movement disorders related to SARS-CoV-2 infection and vaccination in terms of phenomenology, epidemiology, pathogenesis and treatment. After a thorough review of the PubMed and Google Scholar databases (2020-2022), we identified myoclonus and ataxia sometimes accompanied by opsoclonus (AMS) as the two most frequent COVID-19 sequelae, with chorea, tremor and dystonia being very rare. The pathogenesis seems to be variable, but in the majority of AMS cases it was autoimmunological, with good response and recovery after corticosteroids or intravenous immunoglobulins infusions. Vaccination may be complicated by hyperkinetic movement disorders (e.g. tremor, dystonia), but this is very rare. Patients with Deep Brain Simulation depletion should not be postponed due to lockdowns as this may result in fatal outcomes.

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Section: Ataxia/myoclonus/opsoclonus Syndromementioning

confidence: 99%

Hyperkinetic movement disorders following SARS-CoV-2 infection and vaccination — an update

Przytuła¹,

Sławek

2023

Neurol Neurochir Pol.

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“…However, myoclonic jerks were described more frequently in severe COVID-19 compared to other viral illnesses [37], as well as being reported in mild/moderate COVID-19, even in the absence of alternative explanations such as hypoxia [38]. Interestingly, jerks appeared days after the onset of the respiratory symptoms and may last up to several weeks [36,39]. Response to treatment, which included anti-epileptic drugs and immunotherapy, was also variable [36].…”

Section: Neuro-specific Symptomsmentioning

confidence: 99%

Putative Role of the Lung–Brain Axis in the Pathogenesis of COVID-19-Associated Respiratory Failure: A Systematic Review

et al. 2022

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The emergence of SARS-CoV-2 and its related disease caused by coronavirus (COVID-19) has posed a huge threat to the global population, with millions of deaths and the creation of enormous social and healthcare pressure. Several studies have shown that besides respiratory illness, other organs may be damaged as well, including the heart, kidneys, and brain. Current evidence reports a high frequency of neurological manifestations in COVID-19, with significant prognostic implications. Importantly, emerging literature is showing that the virus may spread to the central nervous system through neuronal routes, hitting the brainstem and cardiorespiratory centers, potentially exacerbating the respiratory illness. In this systematic review, we searched public databases for all available evidence and discuss current clinical and pre-clinical data on the relationship between the lung and brain during COVID-19. Acknowledging the involvement of these primordial brain areas in the pathogenesis of the disease may fuel research on the topic and allow the development of new therapeutic strategies.

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“…In the literature, COVID-19-related myoclonus was reported as a complication of an already-known SARS-CoV-2 infection in about 50 patients so far. It generally occurs between 6 days and 26 days following the SARS-CoV-2 infection [2] , [3] , [4] , [5] , and affects critical illness patients with cognitive decline, mainly from the intensive care unit [ 3 , 4 ]. Yet, our patient did not display any symptoms of COVID-19 infection before the occurrence of these abnormal movements.…”

mentioning

confidence: 99%