COVID‐19 presentations and outcome in patients with epilepsy

Asadi‐Pooya, Ali A.; Emami, Amir; Akbari, Ali; Javanmardi, Fatemeh

doi:10.1111/ane.13404

Cited by 37 publications

(42 citation statements)

References 14 publications

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“…In a recent study, we observed that patients with epilepsy were not susceptible to contracting COVID-19 more than that in other individuals. Furthermore, COVID-19 in patients with epilepsy was not associated with a poorer prognosis [17]. In the current study, the seizure outcome in patients, who were hospitalized with COVID-19 and seizures, were generally good.…”

Section: Discussionmentioning

confidence: 42%

A follow-up study of patients with COVID-19 presenting with seizures

Asadi‐Pooya

Kouhanjani

Nemati

et al. 2021

Epilepsy & Behavior

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Objective: We performed a follow-up study of patients with COVID-19 presenting with seizures. Methods: All consecutive patients with seizures, who were referred to Namazee Hospital, Shiraz, Iran, with a diagnosis of COVID-19, from 10 August 2020 until 20 October 2020 were included in this longitudinal study. The clinical data were collected by the admitting physician. In a follow-up phone call to the discharged patients (after eight weeks or more), we inquired their seizure outcome. Results: In total, 32 patients were studied; 28 patients were followed. Twelve patients (37.5%) presented with a single tonic-clonic seizure and nine (28.1%) had convulsive status epilepticus; one patient had functional (psychogenic) seizures. Ten patients (31.3%) had pre-existing epilepsy, eight others (25%) had pre-existing CNS problems (without epilepsy), one person (3.1%) had pre-existing functional seizures, and 13 individuals (40.1%) neither had epilepsy nor had other CNS problems. Eight patients (28.6%) reported experiencing seizure(s) after being discharged from the hospital; six of these had preexisting epilepsy and one had pre-existing functional seizures. One patient, who had a newly developed ischemic brain infarction, reported experiencing recurrent seizures. Conclusion: Seizures in patients with COVID-19 are either acute symptomatic (in about two-thirds) or an exacerbation of a pre-existing epilepsy/functional seizures (in about one-third). A thorough investigation of the underlying etiology of seizures in patients with COVID-19 is necessary. Seizure outcome in patients, who are hospitalized with COVID-19 and seizures, is generally good.

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Section: Discussionmentioning

confidence: 42%

A follow-up study of patients with COVID-19 presenting with seizures

Asadi‐Pooya

Kouhanjani

Nemati

et al. 2021

Epilepsy & Behavior

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“…An early analysis of COVID-19 admissions showed an association between epilepsy and age with a fatal outcome after contracting COVID-19 [5] . In contrast, larger studies did not find any evidence that a SARS-CoV-2 infection per se leads to a worse outcome in PWE than in the normal population [6] . Nevertheless, negative impact of COVID-19 pandemic on PWE in terms of health and health care is well described [7] .…”

Section: Introductionmentioning

confidence: 71%

COVID-19 vaccination in patients with epilepsy: First experiences in a German tertiary epilepsy center

Wrede

Pukropski

Moskau-Hartmann

et al. 2021

Epilepsy & Behavior

112

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Introduction Due to the high demand for information regarding COVID-19 vaccination in people with epilepsy (PWE), we assessed the symptoms and seizure control of PWE following their COVID-19 vaccination. Methods All adult patients who were treated at our center were asked to report on their vaccination status and, if vaccinated, about their experiences following their first COVID-19 vaccination with regard to adverse effects and seizure control. Results Fifty-four PWE have already received their first vaccination against COVID-19 (27 female, 20% seizure free, 96<% on antiseizure medication) and were included in the study. Two-thirds tolerated the vaccines generally either very well or well. Thirty-three percent reported general vaccination adverse effects. The most frequently reported general adverse effects were, in descending order, headache, fatigue and fever, and shivering. With regard to epilepsy-related adverse effects, one patient reported increased seizure frequency one day after the first COVID-19 vaccination was administered, and one reported the occurrence of a new seizure type. None of the patients reported a status epilepticus or aggravation of preexisting adverse effects. Conclusions Our data suggest that vaccination against COVID-19 appears to be well tolerated in PWE, supporting the recommendation of vaccination to PWE.

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“…Eleven article were excluded after the assessment because the outcomes outlined in seven of the articles did not meet the criteria of the present study, three articles had no information on a control group, and one article was not published in English. Thus, 13 studies [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , which included a total of 67,131 patients with COVID-19, were included in the analysis ( Figure 1 ). Of the 13 studies, eight were retrospective cohort studies, three were case-control studies, and two were case-series studies.…”

Section: Resultsmentioning

confidence: 99%