COVID-19 with spontaneous pneumomediastinum

Abstract

with a 1-day history of fever without dizziness, cough, and headaches. On presentation, his temperature was 38•1°C. Laboratory tests showed a C-reactive protein concentration of 0•56 mg/dL (normal range 0•00-0•60] mg/dL). Complete blood count showed elevated leukocytes (10 060 cells per μL [normal range 3500-9500 cells per μL]), neutrophils (7550 cells per μL [1800-6300 cells per μL]), and monocytes (990 cells per μL [100-600 cells per μL]), while the lymphocyte count (1490 cells per μL) was in the normal range (1100-3200 cells per μL). The patient was negative for influenza A and B viruses, adenovirus, respiratory syncytial virus, and parainfluenza 1, 2, and 3 viruses. Chest CT showed multiple ground-glass opacities in the lower lobes bilaterally.The patient was given antibacterial, antiviral, and corticosteroid treatments (moxifloxacin [0•4 g/day] for 5 days, followed by ribavirin [0•5 g/day] and methylprednisolone [40 mg/day] for 5 days) via intravenous drop infusion. However, after 10 days, the patient had persistent fever (highest temperature 38•5°C), cough, and shortness of breath. The patient was diagnosed with coronavirus Contributors CZ and CG contributed to data analysis, data interpretation, the literature search, and manuscript drafting. YX contributed to data collection, data analysis, and figure preparation. MX contributed to study design and reviewed the final draft. All authors read and approved the manuscript.

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