COVID vaccines safely protect pregnant people: the data are in

Hall, Shannon

doi:10.1038/d41586-022-00031-8

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…Although emerging data have revealed the efficacy and safety of COVID-19 vaccination during pregnancy in neonatal and maternal outcomes, vaccination rates among pregnant individuals remain low worldwide. 33 Increasing vaccination rates in pregnant individuals are of paramount importance because they are at high risk for maternal morbidity and adverse perinatal outcomes. However, many pregnant individuals hesitate to receive COVID-19 vaccination despite global vaccination campaigns.…”

Section: Discussionmentioning

confidence: 99%

Peripartum Outcomes Associated With COVID-19 Vaccination During Pregnancy

et al. 2022

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ImportanceThe risk and benefits of COVID-19 vaccination during pregnancy are under investigation. Pooled evidence regarding neonatal and maternal outcomes in association with COVID-19 vaccination during pregnancy is scarce.ObjectiveTo evaluate the association between COVID-19 vaccination during pregnancy and peripartum outcomes.Data SourcesPubMed and EMBASE databases were searched on April 5, 2022. Language restrictions were not applied.Study SelectionProspective trials and observational studies comparing the individuals who received at least 1 COVID-19 vaccination during pregnancy with those who did not and reporting the neonatal outcomes, including preterm birth, small for gestational age, low Apgar score, neonatal intensive care units (NICU) admission, and intrauterine fetal death (IFD).Data Extraction and SynthesisTwo independent investigators extracted relevant data from each study. Odds ratios (ORs) were calculated using a random-effects model. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines.Main Outcomes and MeasuresThe primary outcomes were the neonatal outcomes, including preterm birth, small for gestational age, low Apgar score, NICU admission, and IFD. The secondary outcomes were maternal outcomes, including maternal SARS-CoV-2 infection, cesarean delivery, postpartum hemorrhage, and chorioamnionitis.ResultsNine observational studies involving 81 349 vaccinated (mean age, 32-35 years) and 255 346 unvaccinated individuals during pregnancy (mean age, 29.5-33 years) were included. COVID-19 vaccination during pregnancy was associated with lower risk of NICU admission (OR, 0.88; 95% CI, 0.80-0.97) and IFD (OR, 0.73; 95% CI, 0.57-0.94), whereas there was no statistically significant association with preterm birth (OR, 0.89; 95% CI, 0.76-1.04), small for gestational age (OR, 0.99; 95% CI, 0.94-1.04), and low Apgar score (OR, 0.94; 95% CI, 0.87-1.02). COVID-19 vaccination during pregnancy was associated with a lower risk of maternal SARS-CoV-2 infection (OR, 0.46; 95% CI, 0.22-0.93), whereas it was not associated with increased risk of cesarean delivery (OR, 1.05; 95% CI, 0.93-1.20), postpartum hemorrhage (OR, 0.95; 95% CI, 0.83-1.07), and chorioamnionitis (OR, 0.95; 95% CI, 0.83-1.07).Conclusions and RelevanceCOVID-19 vaccination during pregnancy was not associated with an increase in the risk of peripartum outcomes, was associated with a decreased risk of NICU admission, IFD, and maternal SARS-CoV-2 infection. Thus, COVID-19 vaccination should be encouraged for pregnant individuals.

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Section: Discussionmentioning

confidence: 99%

Peripartum Outcomes Associated With COVID-19 Vaccination During Pregnancy

et al. 2022

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“…Indeed, pregnant women should be considered a population at risk for severe COVID-19. For this reason, public health agencies around the world now recommend that pregnant women receive the COVID-19 vaccine to reduce the risk of this virus to the mother and fetus [17] , [18] , [19] .…”

Section: Discussionmentioning

confidence: 99%

Neonatal outcomes related to maternal SARS-CoV-2 infection in French Guiana: A case-control study.

Elenga

Wandji

Siban

et al. 2022

Journal of Infection and Public Health

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“…Update of COVID-19 vaccine amongst pregnant patients in the US is approximately 40%, compared to a general population background vaccine uptake rate of 63%. 15 The maternal vaccine situation is ever more dismal when global analyses are performed. A systematic review and global meta-analysis of >700,000 pregnant women found that the overall proportion immunized against COVID-19 was only 27.5%.…”

Section: Maternal Covid Vaccination and Protecting The Newborn Infantmentioning

confidence: 99%

What are the key pediatric public policy priorities as the COVID-19 pandemic persists?

2023

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Impact The COVID-19 pandemic is not over, and its impact is just beginning to be felt on children. COVID-19 vaccines protect both the pregnant patient and newborns, and breastfeeding provides a key component of passive protective immunity. “Long COVID” has contributed to the current crisis in pediatric mental health, and vaccines confer protection against this long-term complication of COVID-19 disease. Vaccine misinformation is not only impacting compliance with maternal and pediatric COVID-19 immunization efforts, but also other routine childhood vaccinations. As a public health priority, we must improve our response to vaccine misinformation and find novel strategies to improve vaccine compliance.

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COVID vaccines safely protect pregnant people: the data are in

Cited by 6 publications

References 12 publications

Peripartum Outcomes Associated With COVID-19 Vaccination During Pregnancy

Peripartum Outcomes Associated With COVID-19 Vaccination During Pregnancy

Neonatal outcomes related to maternal SARS-CoV-2 infection in French Guiana: A case-control study.

What are the key pediatric public policy priorities as the COVID-19 pandemic persists?

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