Crackles in asbestos workers: Auscultation and lung sound analysis

Shirai, Fumio; Kudoh, Shoji; Shibuya, Atsuo; Sada, Kazuo; Mikami, Riiciiiro

doi:10.1016/0007-0971(81)90026-7

Cited by 33 publications

(29 citation statements)

References 10 publications

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“…They are an early sign of pulmonary impairment in asbestosis [17,19], a condition that shares close similarities with IPF (including the first appearance of crackles in the lung basal areas [19]). In asbestosis, crackles are present before abnormalities are detected by chest radiograph [20], and are thus useful for screening populations exposed to asbestos [21]. The agreement between observers regarding crackles is sufficiently good to monitor asbestos-exposed workers for crackles [22].…”

mentioning

confidence: 99%

Velcro crackles: the key for early diagnosis of idiopathic pulmonary fibrosis?

2012

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confidence: 99%

Velcro crackles: the key for early diagnosis of idiopathic pulmonary fibrosis?

2012

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“…Earlier studies have suggested that the appearance of crackling lung sounds could be an early sign of pulmonary asbestosis [1,2]. MURPHY and SORENSEN [3] have found that the duration of asbestos exposure associated with auscultatory scoring of crackles and concomitantly with the decrease in pulmonary diffusing capacity.…”

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confidence: 99%

Lung sounds in asbestos induced pulmonary disorders

Piirilä¹,

Lehtola²,

Zitting³

et al. 2000

Eur Respir J

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The aim of the study was to compare the lung sounds in patients with asbestos related pulmonary disorders with findings in high-resolution computed tomography (HRCT), and with lung function variables, in order to find out associations of acoustic changes with radiological fibrosis, emphysema or with pulmonary gas transfer functions.Sixty-four patients with asbestos-related pleural disease, with or without pulmonary disease, were studied. Lung sound recording and analysis was carried out with a computerized lung sound analyser, and HRCT of the chest, as well as forced spirometry and diffusing capacity measurement were performed.The fibrosis score correlated positively with the quartile frequencies of the power spectrum of lung sounds in inspiration (f50) and expiration (f50) and crackle count in inspiration, as well as negatively with diffusing capacity. When the patients with crackling sounds and significant fibrosis were excluded (n=18), emphysema correlated negatively with expiratory quartile frequencies of the power spectrum, with f25 and f50. Furthermore, diffusing capacity correlated with inspiratory f25 and forced expiratory volume in one second with inspiratory f50 when crackles and fibrosis were excluded.Changes in lung sounds were significantly associated with radiologically verified abnormalities and gas transfer of pulmonary tissue. High sound frequencies were associated with fibrotic changes of the lung while low sound frequencies with pulmonary emphysema. Acoustic analysis gives complementary clinical information for evaluation of asbestos-related pulmonary disorders. Eur Respir J 2000; 16: 901±908.

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“…The early presence of crackles before patients are symptomatic and/or lung function is altered has also been reported in conditions where ILD may be expected to develop, namely asbestosis [83][84][85] and rheumatoid arthritis [86]. In the absence of honeycombing at HRCT, the diagnosis of IPF requires a lung biopsy [6].…”

Section: The Value Of Velcro Crackles For Early Diagnosismentioning

confidence: 99%

Neglected evidence in idiopathic pulmonary fibrosis: from history to earlier diagnosis

Cordier¹,

Cottin²

2013

Eur Respir J

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This perspective highlights some evidence that has hitherto been neglected, especially because it may not have been sufficiently explicated in the clinical respiratory medicine literature. Idiopathic pulmonary fibrosis (IPF) has appeared only in the second half of the 20th century and, like lung cancer and chronic obstructive pulmonary disease, may be a direct consequence of the cigarette smoking epidemic. It is a disease of lung ageing, with most affected patients being .70 years of age. The relationship between lung ageing and pulmonary fibrosis is further illustrated in the bleomycin mouse model, in which older males develop more fibrosis than young female mice.Earlier diagnosis of IPF is a prerequisite for significant progress to be made in the long-term outcome and prognosis. We consider that only two different yet complementary and realistic approaches could lead to earlier diagnosis of IPF and possibly to allowing more efficient disease management: 1) investigating any patients with early Velcro crackles at lung auscultation through proactive education of, and commitment from, primary care physicians; and 2) using current large-scale lung cancer screening strategies with lowdose high-resolution computed tomography in smokers for the detection of subclinical interstitial lung disease and especially early IPF. @ERSpublications Only two approaches could lead to earlier diagnosis of IPF and more efficient disease management

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Crackles in asbestos workers: Auscultation and lung sound analysis

Cited by 33 publications

References 10 publications

Velcro crackles: the key for early diagnosis of idiopathic pulmonary fibrosis?

Velcro crackles: the key for early diagnosis of idiopathic pulmonary fibrosis?

Lung sounds in asbestos induced pulmonary disorders

Neglected evidence in idiopathic pulmonary fibrosis: from history to earlier diagnosis

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