Cranberry (Vaccinium macrocarpon) as a prophylaxis for urinary tract infections in women: A systematic review with meta-analysis

Valente, Jessica Damiana Marinho; Pendry, Barbara; Galante, Eva

doi:10.1016/j.hermed.2022.100602

Cited by 9 publications

(6 citation statements)

References 45 publications

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“…Nowadays, the initial empirical knowledge has been translated into scientific evidence by numerous in vitro, ex vivo, and in vivo studies that support the medical recommendation of cranberry consumption for prophylaxis against UTI. However, this general recommendation is not without some controversy due to the large interindividual variability observed in different studies (see Xia et al 36 and Valente et al 37 for recent meta-analyses). Indeed, a full clarification of the action mechanisms of cranberry against UTI would result in a better understanding of the differences between individuals/population groups in response to its consumption and the design of more effective products/ treatments against these infections.…”

Section: ■ Discussionmentioning

confidence: 99%

Cranberry Polyphenols and Prevention against Urinary Tract Infections: New Findings Related to the Integrity and Functionality of Intestinal and Urinary Barriers

González de Llano,

Roldán,

Taladrid

et al. 2024

J. Agric. Food Chem.

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This work seeks to generate new knowledge about the mechanisms underlying the protective effects of cranberry against urinary tract infections (UTI). Using Caco-2 cells grown in Transwell inserts as an intestinal barrier model, we found that a cranberry-derived digestive fluid (containing 135 ± 5 mg of phenolic compounds/L) increased transepithelial electrical resistance with respect to control (ΔTEER = 54.5 Ω cm 2 ) and decreased FITC-dextran paracellular transport by about 30%, which was related to the upregulation of the gene expression of tight junction (TJ) proteins (i.e., occludin, zonula occludens-1 [ZO-1], and claudin-2) (∼3−4-fold change with respect to control for claudin-2 and ∼2−3-fold for occludin and ZO-1). Similar protective effects, albeit to a lesser extent, were observed when Caco-2 cells were previously infected with uropathogenic Escherichia coli (UPEC). In a urinary barrier model comprising T24 cells grown in Transwell inserts and either noninfected or UPEC-infected, treatments with the cranberry-derived phenolic metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and phenylacetic acid (PAA) (250 μM) also promoted favorable changes in barrier integrity and permeability. In this line, incubation of noninfected T24 cells with these metabolites induced positive regulatory effects on claudin-2 and ZO-1 expression (∼3.5-and ∼2-fold change with respect to control for DOPAC and ∼1.5and >2-fold change with respect to control for PAA, respectively). Overall, these results suggest that the protective action of cranberry polyphenols against UTI might involve molecular mechanisms related to the integrity and functionality of the urothelium and intestinal epithelium.

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Section: ■ Discussionmentioning

confidence: 99%

Cranberry Polyphenols and Prevention against Urinary Tract Infections: New Findings Related to the Integrity and Functionality of Intestinal and Urinary Barriers

González de Llano,

Roldán,

Taladrid

et al. 2024

J. Agric. Food Chem.

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“…(36). Cranberry is widely used for the treat on UTIs in adults especially females (37). Its effervescent granules are available but its tablets are not marketed due to the fact that cranberry extract shows over effervescence as it is not properly controlled.…”

Section: Discussionmentioning

confidence: 99%

Vitamin C and Cranberry Extract Effervescent Tablet Formulation, Characterization, and Evaluation

Gillani¹,

Khalid

Said³

et al. 2023

IJPIHS

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Background: Effervescent floating tablets are used oral dosage form, to enhance the patient compliance, drug bioavailability and to increase the absorption rate. Cranberry (Vaccinium macrocarpon), widely used as a preventive agent against urinary tract infections, also suggested for Type II diabetes, myalgic encephalomyelitis, scurvy, and as a diuretic pill for being rich in nutrients and anti-oxidant properties. Objectives: The aim of the study is to formulate and evaluate the effervescent tablets of Cranberry and Vitamin C. Methodology: As per defined criteria of US FDA, effervescent tablet as per composition is formulated by citric acid and sodium bicarbonate and intended to dissolve in water before administration. Active substance and excipient compatibility studies were done by UV and FTIR, resulted absence of any interaction. Pre-formulation studies including Bulk density, tapped density, angle of repose, Hausner’s ratio, Carr’s index and water content. Results: Formulations were evaluated for weight variation, thickness, hardness, pH of solution, drug dissolution time, content uniformity as defined specification of U.S.P and BP. Stability and storage condition studies were also monitored with average results of 96% drug assay and dissolution. All the results showed excellent formulation of tablet and flow properties of granules. Conclusion: Further studies required to approach targeted and spontaneous release of active as optimized effervescence maybe helpful in delivery of actives and enhancing patient compliance.

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“…We found 5 systematic reviews (7-50 RCTs, N=1498-8857). [1][2][3][4][5] The definition of UTI varied: based on symptoms, bacteriuria, or both. Results are statistically different unless noted.…”

Section: Evidencementioning

confidence: 99%

Cranberries for prevention of UTIs

Young,

Allan,

Thomas

2024

Can Fam Physician

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Cranberry (Vaccinium macrocarpon) as a prophylaxis for urinary tract infections in women: A systematic review with meta-analysis

Cited by 9 publications

References 45 publications

Cranberry Polyphenols and Prevention against Urinary Tract Infections: New Findings Related to the Integrity and Functionality of Intestinal and Urinary Barriers

Cranberry Polyphenols and Prevention against Urinary Tract Infections: New Findings Related to the Integrity and Functionality of Intestinal and Urinary Barriers

Vitamin C and Cranberry Extract Effervescent Tablet Formulation, Characterization, and Evaluation

Cranberries for prevention of UTIs

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