Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?

Halver, Jonas; Wenzel, Kristin; Sendker, Jandirk; García, Carmen Carrillo; Erdelmeier, C. A. J.; Willems, Erik; Mercola, Mark; Symma, Nico; Könemann, Stephanie; Koch, E; Hensel, Andreas; Schade, Dennis

doi:10.3389/fphar.2019.01357

Cited by 15 publications

(19 citation statements)

References 56 publications

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“…Within food technology PAC strongly contribute to many relevant properties of the processed products as e.g., colour, taste, texture, and stability. PAC in medicinal plants and in extract-containing phytopharmaceuticals are in many cases assessed as active ingredients, responsible for potential antidiarrheal and wound-healing effects, but also with clinically relevant impact for its documented cardioprotective, neuroprotective, antioxidant, antiinflammatory, antimicrobial and antiviral effects (Gescher et al 2011;Halver et al 2019;Löhr et al 2011;Luca et al 2020;Neilson et al 2016;Rauf et al 2019;Santos-Buelga and Scalbert 2000). As PAC therefore influence the specific properties and functionality of many plant-based products the exact analytical characterization of these polyphenols is essential.…”

Section: Introductionmentioning

confidence: 99%

Advanced analysis of oligomeric proanthocyanidins: latest approaches in liquid chromatography and mass spectrometry based analysis

Symma

Hensel

2021

Phytochem Rev

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Proanthocyanidins (PAC) are an important and widely spread class of natural products with various bioactivities. The analytical evaluation of oligomeric and polymeric proanthocyanidins in complex extracts is still challenging, due to the complexity of structures. Nevertheless, in the last 20 years analytical techniques especially in the field of chromatography and mass spectrometry have been improved and offer exciting possibilities for a deeper insight into plant secondary metabolism. While classical colorimetric methods and protocols for partial hydrolysis are still valuable tools new chromatographically and mass spectrometric methods provide deep insights into the PAC fine structure, also of polymeric material. The present review focus on recent innovative LC–MS and MALDI-TOF methods, innovative strategies for advanced processing of LC-HRMS data (van Krevelen plots, Kendrick Mass Defect Analysis), MS/MS fragmentation, and newest two-dimensional LC × LC (Offline, Online, Stop-flow-2D) chromatography. Also MALDI-TOF imaging provides exciting inside in PAC distribution within biological samples and functional assays.

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Section: Introductionmentioning

confidence: 99%

Advanced analysis of oligomeric proanthocyanidins: latest approaches in liquid chromatography and mass spectrometry based analysis

Symma

Hensel

2021

Phytochem Rev

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“…For example, treatment for 8 weeks with an aqueous ethanol extract from fresh fruits of C. laevigata and C. monogyna , corresponding to a daily dose of 6.4 mg of procyanidins and 12.7 mg total phenolic compounds, significantly improved the exercise ability of patients with congestive heart failure (Degenring et al., 2003). In a recent promising study, C. laevigata was shown to be a useful stimulator of stem cells for cardiomyogenesis and angiogenesis (Halver et al., 2019).…”

Section: Historymentioning

confidence: 99%

Biological Flora of the British Isles: Crataegus laevigata

et al. 2021

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This account presents information on all aspects of the biology of Crataegus laevigata (Poir.) DC (Midland hawthorn) (C. oxyacanthoides Thuill.) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of the Biological Flora of the British Isles: distribution, habitat, communities, responses to biotic factors, responses to environment, structure and physiology, phenology, floral and seed characters, herbivores and disease, history and conservation. Crataegus laevigata is primarily a shade‐tolerant shrub or small tree up to 12‐m tall of ancient woodlands (of which it is an indicator plant) and occasionally old hedges, usually on heavy clay soils and avoiding limestone and chalk. It is native to central and northern Europe and in the British Isles is native to southeast England, occurring naturally up to the Midlands, hence the common name. It is largely absent naturally from Scotland, Wales and Ireland. Flowers usually have two styles, varying from (rarely) 1 to 5 with an equal number of pyrenes in the fruit, differentiating it from C. monogyna with usually one style and pyrene. Pollination is by insects and fruit are dispersed primarily by birds. Fruit has traditionally been used for food, and with the leaves and flowers have a long tradition in herbal medicine. Disturbance and fragmentation have allowed C. monogyna to permeate into old woodlands and hybridise with C. laevigata. These two species are inter‐fertile and barriers to hybridisation are primarily spatial separation thus allowing extensive introgression such that in many parts of Europe, pure C. laevigata is becoming scarce.

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“…As indicated above, many beneficial properties have been attributed to hawthorn, including anticancer [55], anti-HIV, anti-diabetic [56], and anticoagulant activity [57], cardioprotective effects [58][59][60][61][62][63][64][65], hepatoprotective effects, antihyperglycemic and antihyperlipidemic activities, wound healing effects [66], antimicrobial effects, gastroprotective effects, treatment of metabolic syndrome [67], regulation of cholesterol homeostasis [68], anti-atherosclerosis effects [69][70][71][72], anti-aging effects [73], ischemia protective effects [74], treatment of cognitive disorders, neuroprotective effects, regulating gastrointestinal motility [75], anti-inflammatory activities [76,77], regulation of the gut-brain axis [78], treatment of hypertension [79], antioxidant activity [80][81][82][83][84][85], anti-hypoxic activities [86], antidepressant effects [87], anti-Alzheimer's effects, and treatment of intestinal microbial disorder [88].…”

Section: In Vitro and In Vivo Therapeutic Potentials Of Hawthorn: An mentioning

confidence: 99%

Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties

Nazhand

Lucarini²,

Durazzo³

et al. 2020

Forests

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Medicinal plants, many of which are wild, have recently been under the spotlight worldwide due to growing requests for natural and sustainable eco-compatible remedies for pathological conditions with beneficial health effects that are able to support/supplement a daily diet or to support and/or replace conventional pharmacological therapy. The main requests for these products are: safety, minimum adverse unwanted effects, better efficacy, greater bioavailability, and lower cost when compared with synthetic medications available on the market. One of these popular herbs is hawthorn (Crataegus spp.), belonging to the Rosaceae family, with about 280 species present in Europe, North Africa, West Asia, and North America. Various parts of this herb, including the berries, flowers, and leaves, are rich in nutrients and beneficial bioactive compounds. Its chemical composition has been reported to have many health benefits, including medicinal and nutraceutical properties. Accordingly, the present review gives a snapshot of the in vitro and in vivo therapeutic potential of this herb on human health.

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Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?

Cited by 15 publications

References 56 publications

Advanced analysis of oligomeric proanthocyanidins: latest approaches in liquid chromatography and mass spectrometry based analysis

Advanced analysis of oligomeric proanthocyanidins: latest approaches in liquid chromatography and mass spectrometry based analysis

Biological Flora of the British Isles: Crataegus laevigata

Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties

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