Creatine Metabolism and Methyl Testosterone

Tager, B. N.

doi:10.1210/jcem-3-3-185b

Cited by 6 publications

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“…The marked increase in excretion of glycocyamine, a known biological intermediary in the synthesis of creatine, is in keeping with this idea. In this connection it is interesting to speculate on the possibility that the creatinuria following the administration of methyl testosterone results primarily from an increase in the rate of formation of glycocyamine, and that The phenomenon of creatinuria following the administration of methyl testosterone has been cited by Tager (37) as evidence that the hormone acts in large doses as a methylafing substance. The idea that methyl testosterone provokes creatinuria in this manner may be attractive but, unfortunately, is not supported by the facts.…”

Section: Effects Of the Administration Of Methyl Testosterone--methyl Testosteronementioning

confidence: 99%

“…Curves showing the influence of methyl testosterone on the urinary excretion of creatine, creatinine, and glycocyamine in a child with moderately advanced progressive muscular dystrophy. methylation of the glycocyamine occurs secondarily, resulting in an excessive output of creatine.The phenomenon of creatinuria following the administration of methyl testosterone has been cited by Tager(37) as evidence that the hormone acts in large doses as a methylafing substance. The idea that methyl testosterone provokes creatinuria in this manner may be attractive but, unfortunately, is not supported by the facts.…”

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The Synthesis, Storage, and Excretion of Creatine, Creatinine, and Glycocyamine in Progressive Muscular Dystrophy and the Effects of Certain Hormones on These Processes

Hoagland

Gilder

Shank

1945

Journal of Experimental Medicine

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The diminished excretion of creatinine in progressive muscular dystrophy is a more striking and specific phenomenon than the excess excretion of creatine, marked though this is. While creatinuria is invariably encountered in all cases of long-standing dystrophy, the extent to which the excretion of creatinine is decreased provides a more reliable indication of the severity of the disease since an excess output of creatine may occur physiologically in normal human subjects and in many pathological conditions not known to be associated with muscle disease. In progressive muscular dystrophy the residual muscle mass, as inferred from the excretion of creatinine, provides a useful index of the state of the disease at any given time. Although there is excessive creatinuria in progressive muscular dystrophy, there is no evidence that a deprivation of methyl stores occurs through a loss of urinary creatine. The loss of methyl groups contained in the excess creatine is, under ordinary conditions of diet, almost exactly compensated for by a drop in the excretion of methyl groups in the urinary creatinine. Testosterone propionate, administered over variable periods of time, resulted in the retention of creatine both in normal male children and in male children with progressive muscular dystrophy, as shown in the normal subjects by a diminution in creatine output, and in both by an excess creatinuria for variable periods of time following withdrawal of the hormone. An increase in the excretion of creatine in progressive muscular dystrophy occurred following the administration of methyl testosterone. Neither testosterone propionate nor methyl testosterone appeared to effect any consistent change in the output or urinary creatinine. No effects on the excretion of creatine and creatinine were observed following the prolonged administration of concentrate of gonadotropic and thyrotropic principles of the hypophysis, or from the administration of desoxycorticosterone acetate to patients with progressive muscular dystrophy. Except in one case, in which marked improvement was observed following the administration of testosterone propionate, no effects on the clinical course of the patients with progressive muscular dystrophy were observed as a result of treatment by any of the various hormones employed in this study.

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Section: Effects Of the Administration Of Methyl Testosterone--methyl Testosteronementioning

confidence: 99%

mentioning

confidence: 99%

The Synthesis, Storage, and Excretion of Creatine, Creatinine, and Glycocyamine in Progressive Muscular Dystrophy and the Effects of Certain Hormones on These Processes

Hoagland

Gilder

Shank

1945

Journal of Experimental Medicine

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Jaundice Due to Methyltestosterone Therapy

Wood¹

1952

JAMA

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rubbing an indelible pencil on a sheet of paper. Application of a sodium bicarbonate solution has no effect; however a 2% fluorescein solution will remove the marks completely in a few minutes.When the case was discussed with Prof. Troy C. Daniels, dean of the College of Pharmacy, University of California, he recognized the nature of the reaction at once. He stated that the copying leads in violet colored indelible pencils appear to uniformly contain approximately 30% of methylrosaniline chloride together with graphite and a binder such as gum tragacanth. The principal toxic ingredient is, of course, the methylrosaniline chloride, which is a protoplasmic poison. It was reported by Gierlich 6 to destroy the erythrocytes, causs methemoglobin formation, and result in anemia.The tfiphenylmethane dyes are compounds of rela-

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Fertilitätsstörungen beim Manne Somatischer Teil

Heinke¹,

Doepfmer²

1960

Fertilitätsstörungen Beim Manne

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Creatine Metabolism and Methyl Testosterone

Cited by 6 publications

References 0 publications

The Synthesis, Storage, and Excretion of Creatine, Creatinine, and Glycocyamine in Progressive Muscular Dystrophy and the Effects of Certain Hormones on These Processes

The Synthesis, Storage, and Excretion of Creatine, Creatinine, and Glycocyamine in Progressive Muscular Dystrophy and the Effects of Certain Hormones on These Processes

Jaundice Due to Methyltestosterone Therapy

Fertilitätsstörungen beim Manne Somatischer Teil

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