Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism

Deminice, Rafael; Castro, Gabriela Salim de; Francisco, Lucas Vieira; Silva, Lilian Eslaine Costa Mendes da; Cardoso, João Felipe Rito; Frajacomo, Fernando Tadeu Trevisan; Teodoro, Bruno Gonzaga; Silveira, Leonardo R.; Jordão, Alceu Afonso

doi:10.1016/j.jnutbio.2014.11.014

Cited by 32 publications

(20 citation statements)

References 39 publications

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“…3C, D). Synthesis of creatine requires a large amount of methyl groups (Mudd and Poole, 1975), and creatine supplementation prevents the hepatic consequences of a choline-deficient diet (Deminice et al, 2015). However, we found that creatine levels are higher in serum of CC + colonized mice compared with the CC − group (Fig.…”

Section: Resultsmentioning

confidence: 99%

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Romano

Campo

Kasahara

et al. 2017

Cell Host & Microbe

167

139

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SUMMARY Choline is an essential nutrient and methyl donor required for epigenetic regulation. Here, we assessed the impact of gut microbial choline metabolism on bacterial fitness and host biology by engineering a microbial community that lacks a single choline-utilizing enzyme. Our results indicate that choline-utilizing bacteria compete with the host for this nutrient, significantly impacting plasma and hepatic levels of methyl-donor metabolites and recapitulating biochemical signatures of choline deficiency. Mice harboring high levels of choline-consuming bacteria showed increased susceptibility to metabolic disease in the context of a high-fat diet. Furthermore, bacterially-induced reduction of methyl-donor availability influenced global DNA methylation patterns in both adult mice and their offspring and engendered behavioral alterations. Our results reveal an underappreciated effect of bacterial choline metabolism on host metabolism, epigenetics, and behavior. This work suggests that interpersonal differences in microbial metabolism should be considered when determining optimal nutrient intake requirements.

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Section: Resultsmentioning

confidence: 99%

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Romano

Campo

Kasahara

et al. 2017

Cell Host & Microbe

167

139

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“…In this regard, creatine supplementation has been reported to help lower cholesterol and triglyceride levels [67, 196]; reduce fat accumulation in the liver [197]; reduce homocysteine levels [198]; serve as an antioxidant [199–202]; enhance glycemic control [132, 203–205]; slow tumor growth in some types of cancers [32, 198, 206, 207]; increase strength and/or muscle mass [37, 41, 44, 45, 82, 208–212]; minimize bone loss [211, 212]; improve functional capacity in patients with knee osteoarthritis [213] and fibromyalgia [214]; positively influence cognitive function [43, 83, 195]; and in some instances, serve as an anti-depressant [215–217]. …”

Section: Potential Medical Uses Of Creatinementioning

confidence: 99%

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine

Kreider

Kalman²,

António

et al. 2017

Journal of the International Society of Sports Nutrition

513

602

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Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations which may help explain the observed improvements in high intensity exercise performance leading to greater training adaptations. In addition to athletic and exercise improvement, research has shown that creatine supplementation may enhance post-exercise recovery, injury prevention, thermoregulation, rehabilitation, and concussion and/or spinal cord neuroprotection. Additionally, a number of clinical applications of creatine supplementation have been studied involving neurodegenerative diseases (e.g., muscular dystrophy, Parkinson’s, Huntington’s disease), diabetes, osteoarthritis, fibromyalgia, aging, brain and heart ischemia, adolescent depression, and pregnancy. These studies provide a large body of evidence that creatine can not only improve exercise performance, but can play a role in preventing and/or reducing the severity of injury, enhancing rehabilitation from injuries, and helping athletes tolerate heavy training loads. Additionally, researchers have identified a number of potentially beneficial clinical uses of creatine supplementation. These studies show that short and long-term supplementation (up to 30 g/day for 5 years) is safe and well-tolerated in healthy individuals and in a number of patient populations ranging from infants to the elderly. Moreover, significant health benefits may be provided by ensuring habitual low dietary creatine ingestion (e.g., 3 g/day) throughout the lifespan. The purpose of this review is to provide an update to the current literature regarding the role and safety of creatine supplementation in exercise, sport, and medicine and to update the position stand of International Society of Sports Nutrition (ISSN).

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“…We were also interested in determining whether creatine supplementation could restore the depleted hepatic and extrahepatic creatine levels observed after EtOH administration. These proposed studies to examine whether supplementation with creatine prevented alcoholic liver injury were even more appropriate in light of recent reports which revealed that creatine supplementation could prevent choline‐deficient or high‐fat‐diet‐induced hepatic steatosis (Deminice et al., , ).…”

mentioning

confidence: 99%

Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis

Ganesan

Feng

Barton

et al. 2016

Alcoholism Clin & Exp Res

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Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism

Cited by 32 publications

References 39 publications

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine

Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis

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