Creating a risk model to determine paraaortic lymph node involvement in endometrial carcinoma

Turan, Ahmet Taner; Yildirim, Burcu Aykan; Üreyen, Işın; Hızlı, Deniz; Karalök, Mustafa Alper; Tapisiz, Omer Lutfi; Tulunay, Hakkı Gökhan; Boran, Nurettin; Özgül, Nejat; Köse, Mehmet

doi:10.3906/sag-1201-27

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Considering types of regional lymph nodes metastases in relation to depth of myometrial invasion in type 1 endometrial cancer, the present study showed that cases with deep myometrial invasion is associated with more pelvic and lower paraaortic lymph nodes metastasis than cases with superficial myometrial invasion. In agreement with the present study, Turan et al, study proved that deep myometrial invasion showed significant increase in pelvic and para-aortic lymph nodes group metastasis than in superficial myometrial invasion in endometrial adenocarcinoma patients (19). From the previous finding we can conclude that deep myometrial invasion is an important causative factor of regional lymph nodes metastases, has an upper role than pathological grading in relation to this aspect in type 1 endometrial cancer and is associated with more pelvic and lower para-aortic lymph nodes metastasis.…”

Section: Discussionsupporting

confidence: 93%

Comparative Study Between Superficial and Deep Myometrial Invasion in Endometrial Cancer Type 1 in Relation to Regional Lymph Nodes Metastasis

El Sokkary

2023

J Obstet Gynecol Cancer Res

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Background & Objective: The present study compares between superficial and deep myometrial invasion in type 1 endometrial cancer in relation to regional lymph nodes metastasis, so we can answer the question to do or not do lymphadenectomy, this lifethreatening procedure in both superficial and deep myometrial invasion with type 1, clinically and radiologically stage 1 endometrial cancer.Materials & Methods: Patients were divided into 2 groups distributed as follows: group I includes 50 patients type 1 endometrial cancer with superficial myometrial invasion and group II includes 50 patients type 1 endometrial cancer with deep myometrial invasion. Total abdominal hysterectomy with bilateral salpingo-opherectomy with pelvic and lower para-aortic lymphadenectomy to all patients included in the study from both groups. Histopathological examinations were done to all the specimen from both groups to confirm diagnosis of type 1 endometrial cancer, depth of myometrial invasion, pathological grading and metastasis to the regional lymph nodes.Results: Considering regional lymph nodes metastasis in both groups, there is a statistical difference between group I and group II in relation to regional lymph nodes metastasis as group II (cases with deep myometrial invasion) are associated with more regional lymph nodes metastasis (P= 0.0001)). Conclusion:Deep myometrial invasion in type 1 endometrial cancer is associated with significant increase in regional lymph nodes metastases.

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Section: Discussionsupporting

confidence: 93%

Comparative Study Between Superficial and Deep Myometrial Invasion in Endometrial Cancer Type 1 in Relation to Regional Lymph Nodes Metastasis

El Sokkary

2023

J Obstet Gynecol Cancer Res

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“…This is due to the variability of tumor localization and the apparent incidence of adnexal metastasis in endometrial carcinoma. Therefore, the lymphatic chain pattern is not associated with predictable lymphatic spread in endometrial carcinoma (14). Turan et al (14) aimed to define a high-risk group for PALN metastasis in patients with endometrial cancer and showed that PALN involvement significantly increased in patients with highrisk endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the lymphatic chain pattern is not associated with predictable lymphatic spread in endometrial carcinoma (14). Turan et al (14) aimed to define a high-risk group for PALN metastasis in patients with endometrial cancer and showed that PALN involvement significantly increased in patients with highrisk endometrial cancer. Although PLN and PALN were excised more in high-risk cases evaluated in this study, no significant relationship was found between the presence of lymph node metastasis and patient risk groups.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of risk factors for pelvic and paraaortic lymph node metastasis in endometrioid type endometrial cancer

Dogan

Şirinoğlu

2023

Journal of Health Sciences and Medicine

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Aim: Determining the relationship between clinical and pathological features in endometrial cancer is essential for both prognostic and potential therapeutic benefits. In this study, we aimed to investigate the relationship between pelvic and paraaortic lymph node (PLN and PALN) metastasis and prognostic factors in patients with endometrial cancer (EC). Materials and Method: Medical records of patients who underwent primary surgery for EC in our gynecological oncology center between the 2016 and 2018 were reviewed retrospectively. The relationship between pelvic and paraaortic lymph node metastasis was evaluated with data such as patient age, body mass index, serum CA 125 level, macroscopic tumor diameter, and patients’ risk groups. Results: Fifty-seven patients with EC were evaluated. Lymph node involvement was detected in 10 patients (17.5%). Acording to Modiffied Mayo criterias ; the patients with grade 3 EC had a higher risk of metastasis compared to other grades (p=0.025). Patients with lymph node metastases had a greater depth of invasion (p=0.001). There was no relationship between tumor size and lymph node metastasis (p=0.494). In the logistic regression analysis, the depth of invasion was found to be an independent risk factor for lymph node metastasis. There was no significant relationship between the presence of PLN and PALN metastases in patients with high-risk endometrial cancer, but the presence of PALN metastasis was significant in patients with low-risk endometrial cancer with PLN metastasis (p=0.002). Conclusion: These findings support the idea that routine evaluation of tumor invasion depth during endometrial cancer surgery may be useful in predicting lymph node metastasis and guiding the operation.

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The expression of cell adhesion molecules in colorectal cancer tissue and its clinical values

Chen¹,

Zhao²,

Feng³

2013

Turk J Med Sci

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The present work focused on the design of a drug delivery system (DDS) based on pH-sensitive hydrogel.The hydrogels were prepared via graft copolymerization of mixtures of acrylic acid (AA) and 2-hydroxy ethyl methacrylate (HEMA) onto starch backbones by a free radical polymerization technique. Sodium bicarbonate (NaHCO 3) was added to function as a foaming agent under acidic conditions, rendering the hydrogels to be porous. The porous structure of the hydrogel was essential in this system to yield a large surface area so that 5-fluorouracil (5-FU) release could be facilitated. The hydrogel, thus prepared, possessed a porous structure as determined by scanning electron microscopy.The water absorbency of the hydrogels was measured in solutions with pH levels ranging from 1 to 13. The starch-based hydrogel exhibited a pH-responsiveness character such that a swelling-deswelling pulsatile behavior was recorded at pH levels of 2 and 7. Using the drug 5-FU as a model molecule, the in vitro controlled drug-release behaviors of these hydrogels were investigated. The results indicate that the main parameter affecting the drug-release behavior of hydrogels is the pH of the solution. The release rate of 5-FU from hydrogel at pH 7.4 was faster than that at pH 1.2 due to the shrinkage of the hydrogel at pH 1.2.These results suggest that a porous hydrogel could potentially be a useful local delivery system to release drugs, primarily at a specific site of body.

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Creating a risk model to determine paraaortic lymph node involvement in endometrial carcinoma

Cited by 3 publications

References 17 publications

Comparative Study Between Superficial and Deep Myometrial Invasion in Endometrial Cancer Type 1 in Relation to Regional Lymph Nodes Metastasis

Comparative Study Between Superficial and Deep Myometrial Invasion in Endometrial Cancer Type 1 in Relation to Regional Lymph Nodes Metastasis

Evaluation of risk factors for pelvic and paraaortic lymph node metastasis in endometrioid type endometrial cancer

The expression of cell adhesion molecules in colorectal cancer tissue and its clinical values

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