Creatinine Transport by Basolateral Organic Cation Transporter hOCT2 in the Human Kidney

Urakami, Yumiko; Kimura, Naoko; Okuda, Masahiro; Inui, Kentaro

doi:10.1023/b:pham.0000029286.45788.ad

Cited by 194 publications

(154 citation statements)

References 33 publications

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“…The secretory components of C cr correlated significantly and positively with glycemic control indices of hemoglobin A 1c and GA, suggesting that increased secretion of creatinine was related to the hyperglycemic condition. Organic cation transporters, which have been reported to be associated with creatinine secretion in renal tubuli (33), are modulated by high glucose in rats via the increased oxidative stress of advanced glycation end products (34).…”

Section: Discussionmentioning

confidence: 99%

Poor Glycemic Control Is a Major Factor in the Overestimation of Glomerular Filtration Rate in Diabetic Patients

et al. 2014

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OBJECTIVESerum creatinine levels are lower in diabetic patients compared with their nondiabetic counterparts. Therefore, estimated glomerular filtration rate (eGFR) is higher in the former than in the latter group. Factors associated with overestimation of renal function in diabetic patients were examined, and new formulae reflecting precise eGFR were created. RESEARCH DESIGN AND METHODSEighty subjects (age 56.5 6 15.4 years; 35 males [43.8%]; 40 patients with diabetes and 40 nondiabetic subjects) were enrolled. GFR was evaluated by inulin clearance (C in ). eGFR values were calculated based on serum creatinine and/or serum cystatin C levels. The factors related to the dissociation between eGFR and C in in diabetic patients and the agreement among each of three eGFR and C in were compared. RESULTSAlthough C in was not significantly different between the diabetic and nondiabetic subjects (P = 0.2866), each of three eGFR measures from the diabetic patients was significantly higher than that of the nondiabetic subjects (P < 0.01). There were significant and positive correlations between the ratio of each eGFR/ C in , hemoglobin A 1c , and glycated albumin. The intraclass correlation coefficients in diabetic patients were weaker than those in the nondiabetic subjects, and the intercepts of the regression lines between each eGFR measure and C in in the diabetic patients were significantly higher than those of the nondiabetic subjects. New formulae for the calculation of eGFR corrected by the glycemic control indices were better than the original eGFR, particularly in diabetic patients. CONCLUSIONSeGFR overestimates C in as glycemic controls worsen. eGFR corrected by hemoglobin A 1c is considered to be clinically useful and feasible.

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Section: Discussionmentioning

confidence: 99%

Poor Glycemic Control Is a Major Factor in the Overestimation of Glomerular Filtration Rate in Diabetic Patients

et al. 2014

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“…The Na ϩ -free incubation buffer was prepared by replacing Na ϩ with N-methyl-D-glucamine or choline. The experimental procedures and the composition of other incubation buffers were described previously (43). Concentration dependence of riboflavin transport was fit by the combination of the Michaelis-Menten equation and a linear relationship:…”

Section: Methodsmentioning

confidence: 99%

Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1

Yonezawa¹,

Masuda²,

Katsura³

et al. 2008

American Journal of Physiology-Cell Physiology

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129

101

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“…Glomerular filtration accounts for the majority of creatinine elimination, but creatinine is actively secreted by number of transporters expressed in proximal tubules [53,54]. Specially, human organic cation transporters (hOCT2) [55] and anionic transporters secrete creatinine [53,[56][57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Serum creatinine and cystatin C provide conflicting evidence of acute kidney injury following acute ingestion of potassium permanganate and oxalic acid

Wijerathna

Gawarammana

Dissanayaka

et al. 2017

Clinical Toxicology

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Acute Kidney Injury (AKI) is common following deliberate self-poisoning with a combination washing powder containing oxalic acid (H2C2O4) and Potassium permanganate (KMnO4). Early and rapid increases in serum creatinine (sCr) follow severe poisoning.We investigated the relationship of these increases with direct nephrotoxicity in an ongoing multicenter prospective cohort study in Sri Lanka exploring AKI following poisoning. Multiple measures of change in kidney function were evaluated in 48 consenting patients who had serial sCr and serum cystatinC (sCysC) data available.Thirty eight (38/48, 79%) patients developed AKI (AKIN criteria). Twenty eight (58%) had AKIN stage 2 or 3. Initial increases in urine creatinine (uCr) excretion were followed by a substantial loss of renal function. The AKIN stage 2 and 3 (AKIN2/3) group had very rapid rises in sCr (a median of 118% at 24 hours and by 400% at 72 hours post ingestion). We excluded the possibility that the rapid rise resulted from the assay used or muscle damage. In contrast, the average sCysC increase was 65% by 72 hours.In most AKI, sCysC increases to the same extent but more rapidly than sCr, as sCysC has a shorter half-life. This suggests either a reduction in Cystatin C production or, conversely, that the rapid early rise of sCr results from increased production of creatine and creatinine to meet energy demands following severe oxidative stress mediated by oxalic acid and KMnO4. Increased early creatinine excretion supports the latter explanation, since creatinine excretion usually decreases transiently in AKIN2/3 from other causes.

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Creatinine Transport by Basolateral Organic Cation Transporter hOCT2 in the Human Kidney

Abstract: These results suggest that hOCT2, but not hOCT1, is responsible for the basolateral membrane transport of creatinine in the human kidney.

Cited by 194 publications

References 33 publications

Poor Glycemic Control Is a Major Factor in the Overestimation of Glomerular Filtration Rate in Diabetic Patients

Poor Glycemic Control Is a Major Factor in the Overestimation of Glomerular Filtration Rate in Diabetic Patients

Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1

Serum creatinine and cystatin C provide conflicting evidence of acute kidney injury following acute ingestion of potassium permanganate and oxalic acid

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