Cribado de cromosomopatías fetales en España. Cambios hospitalarios en el periodo 2006–2011

Galán, Sebastián Manzanares; Llorens, Alicia Pineda; Pérez, M. D.; Criado, María Setefilla López; Vallejo, José Luis

doi:10.1016/j.diapre.2012.01.002

Cited by 4 publications

(1 citation statement)

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“…Data is processed by siPACAC, which yields a risk estimate. If risk is high, patients are offered an invasive procedure such as amniocentesis or chorionic villi sampling (CVS), with the risks that these procedures entail for the mother and the fetus [4,5].…”

Section: Introductionmentioning

confidence: 99%

Assessment of a change of protocol of prenatal screening by inclusion of non-invasive prenatal diagnosis

Cabra-Rodríguez

Rodríguez

Rosa

et al. 2020

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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AbstractObjectivesNon-invasive prenatal screening (NIPS) is a test for the detection of major fetal chromosomal abnormalities in maternal blood during pregnancy. The purpose of this study was to assess the performance of NIPS implemented within the framework of the Screening Program for Congenital Abnormalities of the Andalusian Health System.MethodsA retrospective observational study was undertaken to determine the number of NIPS tests performed since its introduction. The number of invasive diagnostic tests done after the implementation of NIPS in the patients included in the program between March 2016 and August 2017 was also quantified.ResultsA total of 6,258 combined first- and second trimester screening tests were performed, covering 95% of the population. In total, 250 subjects were identified as high risk, of whom 200 underwent NIPS after loss to follow-up. NIPS showed a sensitivity of 100% (95% CI: 76.84–100%) and a specificity of 99.46% (95% CI: 97.04–99.99%).ConclusionsThis test has proven to have a very high sensitivity and specificity. The results obtained demonstrate that the incorporation of NIPS in clinical practice minimizes the rate of miscarriages and reduces the frequency of invasive procedures by 70%.

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Section: Introductionmentioning

confidence: 99%