Critical Review on Steviol Glycosides: Pharmacological, Toxicological and Therapeutic Aspects of High Potency Zero Caloric Sweetener

Mathur, Shaifali; Bulchandani, Neha; Parihar, Suman; Shekhawat, G. S.

doi:10.3923/ijp.2017.916.928

Cited by 57 publications

(32 citation statements)

References 59 publications

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“…It is known that stevioside, isoesteviol, steviol, follicular aglycones, and other metabolites inhibit tumor formation in several ways: by blocking the early antigen of Epstein-Barr virus, induction and also by reducing the production of tumors in the model of carcinogenesis of the mouse skin in two stages after exposure to 7,12 dimetibenz [a] anthracene and 12-O-tetradecanoylphorbol-13acetate. 23 A compound of diterpenic nature present in the extract of the stevia leaf known as Labdane sclareol has antitumor and cytotoxic properties. 24 Studies have shown the inhibitory effects of extracts and their polyphenolic components in the promotion and initiation of tumors.…”

Section: Antitumoral Effectmentioning

confidence: 99%

A comprehensive review on the nutritional and therapeutical aspects of Stevia rebaudiana bertoni

Nathalie¹,

Elena²,

Escobedo³

2019

JABB

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In late years there has been an increase of scientific evidence that supports the use of Stevia rebaudiana Bertoni (S. rebaudiana) as an alternative to sucrose and artificial sweeteners. In addition to its utility in different industries, S.rebaudiana contains various chemical components with potential benefits for human health such as polyphenols, chlorophylls, carotenoids, among others, which can be extracted for the production of nutraceuticals and functional foods. So far no adverse effects on human health have been proven after ingestion and favorable results have been documented when S.rebaudiana or its derivates are included in treatments against diabetes, certain types of cancer, glucose intolerance, obesity, dental cavities, among others. The purpose of this review is to provide an overview of the clinical, chemical and biochemical literature that presents evidence of the beneficial role of Stevia rebaudiana Bertoni and its metabolites in health promotion properties, as well as its relevance in the pharmaceutical and food industries

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Section: Antitumoral Effectmentioning

confidence: 99%

A comprehensive review on the nutritional and therapeutical aspects of Stevia rebaudiana bertoni

Nathalie¹,

Elena²,

Escobedo³

2019

JABB

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“…Its leaves contain steviol glycosides (including stevioside, rebaudioside (A to F), steviolbioside, and isosteviol, among which stevioside, rebaudioside A, and rebaudioside C are the major metabolites [ 2 ]), polyphenols, chlorophylls, and carotenoids [ 3 ]. Such extractives have been suggested to exert beneficial effects on human health [ 4 , 5 , 6 ], and several studies have covered their antimicrobial activity [ 7 , 8 , 9 , 10 ]. Nonetheless, a literature survey revealed that their antifungal/fungistatic activity has been little studied [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity against Fusarium culmorum of Stevioside, Silybum marianum Seed Extracts, and Their Conjugate Complexes

et al. 2020

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Fusarium head blight (FHB) is a disease that poses a major challenge in cereal production that has important food and feed safety implications due to trichothecene contamination. In this study, the effect of stevioside—a glycoside found in the leaves of candyleaf (Stevia rebaudiana Bertoni)—was evaluated in vitro against Fusarium culmorum (W.G. Smith) Sacc., alone and in combination (in a 1:1 molar ratio) with polyphenols obtained from milk thistle seeds (Silybum marianum (L.) Gaertn). Different concentrations, ranging from 32 to 512 µg·mL−1, were assayed, finding EC50 and EC90 inhibitory concentrations of 156 and 221 µg·mL−1, respectively, for the treatment based only on stevioside, and EC50 and EC90 values of 123 and 160 µg·mL−1, respectively, for the treatment based on the stevioside–polyphenol conjugate complexes. Colony formation inhibition results were consistent, reaching full inhibition at 256 µg·mL−1. Given that synergistic behavior was observed for this latter formulation (SF = 1.43, according to Wadley’s method), it was further assessed for grain protection at storage, mostly directed against mycotoxin contamination caused by the aforementioned phytopathogen, confirming that it could inhibit fungal growth and avoid trichothecene contamination. Moreover, seed tests showed that the treatment did not affect the percentage of germination, and it resulted in a lower incidence of root rot caused by the pathogen in Kamut and winter wheat seedlings. Hence, the application of these stevioside–S. marianum seed extract conjugate complexes may be put forward as a promising and environmentally friendly treatment for the protection of cereal crops and stored grain against FHB.

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“…Recent research has focused on the potential uses of certain sweeteners, such as stevioside, to treat some conditions, including diabetes, heart disease, and even cancer. [5][6][7][8] While there is still much research to be done in these areas, early results demonstrate the overall positive effects these compounds may have in medical research.…”

Section: Introductionmentioning

confidence: 99%

“…14 In the body, stevioside is metabolized by the small intestine, liver, and kidneys, although very little of the substance is absorbed into the blood. 7 A 2007 study on the metabolism of stevioside found that there are three major byproducts in the body after ingestion of stevioside; namely, steviol in the intestine, unchanged stevioside in the intestine, and approximately 205mg/hour of steviol glucuronide in the urine, amongst others. 14 It has been confirmed several times that a large part of the metabolism into steviol and its constituent glycoside chains occurs in large part due to gut microbiota, as humans lack the enzymes to metabolize the compound.…”

Section: Introductionmentioning

confidence: 99%

“…5,14 In a physiological context, stevioside have been implicated as being anti-hypertensive, cardiotonic, anti-carcinogenic, and antiinflammatory in several contexts. [5][6][7][8] Many researchers are investigating their anti-carcinogenic properties and they have been proposed, albeit tentatively, as potential anti-cancer drugs. Unlike many other natural sweeteners, there seems to be some level of consensus as to the safety of consumption of stevioside.…”

Section: Introductionmentioning

confidence: 99%

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The effect of natural sugar and sweeteners on normal and cancerous human fibroblasts

Eric¹,

Lee²,

Choil³

et al. 2019

JABB

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Non-nutritive sweeteners (NNS) have seen increasingly common usage amongst foodstuffs in the westernized diet in the past few decades, including processed foods and flavored beverages. Recently, an increasing body of research has been evaluating the potential of NNS for alternative uses in healthcare and medicine. Some of these sweeteners, such as stevioside, have been implicated as being anti-hypertensive, anti-carcinogenic, and anti-inflammatory in several contexts. To examine the potential of NNS such as stevioside as an anti-carcinogenic agent, cellular behavior of HFF-1 human foreskin fibroblasts (ATCC SCRC-1041) & COLO-829 human melanoma fibroblasts (ATCC CRL-1974) was observed in the presence of sucrose, sucralose, and stevioside on collagen. This study examined the impact of NNS on initial adhesion, cellular proliferation, and integrin expression on healthy and cancerous fibroblast cell lines. The results indicate that 5 mg/mL stevioside caused more than 2-fold decrease in the initial adhesion of healthy cells but caused more than 4-fold increase in the initial adhesion of cancerous cells. In terms of proliferation, stevioside at 5 mg/mL caused a 13-fold decrease in cancer cell proliferation, proportional to concentration, but a 1.5-fold increase in proliferation for healthy cells.

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Critical Review on Steviol Glycosides: Pharmacological, Toxicological and Therapeutic Aspects of High Potency Zero Caloric Sweetener

Cited by 57 publications

References 59 publications

A comprehensive review on the nutritional and therapeutical aspects of Stevia rebaudiana bertoni

A comprehensive review on the nutritional and therapeutical aspects of Stevia rebaudiana bertoni

Antifungal Activity against Fusarium culmorum of Stevioside, Silybum marianum Seed Extracts, and Their Conjugate Complexes

The effect of natural sugar and sweeteners on normal and cancerous human fibroblasts

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