The results of the observation showed that there were still many students in histology subjects who did not yet have critical thinking competencies and maximum histology concept. The purpose of this study was to find out how project-based learning through blended learning can develop critical thinking skills and student histology concept. This type of research is classroom action research. The sample of this study was students of class C histology class 2018/2019 as many as 35 students of Malang Muhammadiyah University. The research method is in the form of observation, interviews, and tests. The learning management system used in this research blended learning uses Edmodo. The results showed that there was a change in the improvement of critical thinking skills and student histology concept from cycle I to cycle II. Critical thinking skills in the cycle I showed that 23% were complete and 77% were non-complete, while the cycle II was 80% complete and 20% non-compete. Critical thinking skills from cycle I to cycle II increased by 57%. Histology concept in the cycle I found 69% complete and 31% non-complete, while the cycle II was 100% complete and 0% non-complete. Histology concept from cycle I to cycle II increased by 31%. Based on this, project-based learning through blended learning can develop critical thinking skills and student histology concept.