Critical thresholds of liver function parameters for ketosis prediction in dairy cows using receiver operating characteristic (ROC) analysis

Sun, Yuhang; Wang, Bo; Sheng, Shi; Zhang, Hongyou; Xu, Chuang; Wu, Lina; Xia, Cheng

doi:10.1080/01652176.2015.1028657

Cited by 34 publications

(21 citation statements)

References 28 publications

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“…Although the average total bilirubin values in the animals of all groups were within the physiological limits (0.01-0.47 mg/dL) (3), the average values in the clinical ketosis group were significantly higher (P < 0.05) than those in the control group; some individual values were even above the physiological limits in the group with clinical ketosis. The average values of total bilirubin, which were found in the cows with clinical ketosis, were mostly in agreement with those reported in other studies (1,3,5,16) about cows with azotemia.…”

Section: Discussionsupporting

confidence: 91%

“…The increases in AST activity and total bilirubin levels in animals included in the sick study groups show the existence of liver damage in ketosis patients, in line with findings reported in other studies (3,5,16).…”

Section: Discussionsupporting

confidence: 91%

“…Because ketosis (whose primary metabolic disorders are hyperketonemia and hypoglycemia) does not have pathognomonic symptoms, ketone bodies in the blood, urine, and milk (acetone, acetoacetic acid, β-hydroxybutyric acid, or isopropanol), and blood glucose amounts are used for its diagnosis (1,3). It has been reported in recent years that β-hydroxybutyric acid quantification in serum or plasma is the gold standard test to diagnose and distinguish ketosis (1,3,10,15,16). If the serum β-hydroxybutyric acid level is less than 1000 µmol/L, it is considered normal; if it is between 1000 and 1400 µmol/L, subclinical ketosis is diagnosed; and if it is above 2500 µmol/L, clinical ketosis is diagnosed (2).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis

Issi¹,

Gül²,

Başbuğ³

2016

Turk J Vet Anim Sci

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Introduction Ketosis is a disease leading to economic losses because of its treatment costs and the decrease in milk yield and fertility (1-3). It is a subacute and chronic carbohydrate metabolism disorder caused by a negative energy balance as a result of a failure to meet the growing energy need in the first months of lactation in highly productive dairy cows. It is characterized by the consumption of liver glycogens and other glucose reserves, a decrease in glyconeogenetic activity, fatty degeneration in the liver, hypoglycemia, ketonemia, ketonuria, ketolactia, and an increase in ketone bodies in the respiratory air (1-4). Ketosis arises primarily from insufficient intake of appropriate feeds or secondarily from the prevention of feed intake due to other diseases, including retentio secundunarium, metritis, mastitis, traumatic reticuloperitonitis, and left displaced abomasum (1-3). It can also be classified as subclinical or clinical according to the existence of clinical symptoms and the levels of ketone bodies in the blood, urine, and milk (3). Its clinical form has digestive and nervous presentations (2). Gul and Grunder (5) reported increases in bilirubin, aspartate amino transaminase (AST), and serum bile acids due to liver degeneration in dairy cows with ketosis. It was reported by Li et al. (6) that renal functions were slightly disrupted in dairy cows with subclinical ketosis and new studies were needed to explore the extent of this disruption. The purpose of the present study was to research the changes in renal and hepatic functions of highly productive dairy cows diagnosed with subclinical and clinical ketosis. 2. Materials and methods The study involved 30 high milk yielding dairy cows aged between 3 and 7 years. The breeds Brown Swiss (5 heads), Holstein (18 heads), and Simmental (4 heads), and their crossbreeds (3 heads) were represented. The diagnosis of ketosis was based on anamnesis, physical examination, the determination of ketone bodies in the urine, and serum β-hydroxybutyric acid. The animals were divided according to their serum β-hydroxybutyric acid levels into control, subclinical, and clinical ketosis groups, each of which included 10 cows. The cows in the control and subclinical ketosis groups were from various facilities in Elazığ's central district, while those in the clinical ketosis group were selected from animals admitted to the clinics

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis

Issi¹,

Gül²,

Başbuğ³

2016

Turk J Vet Anim Sci

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“…Karaciğerin işlevselliği ve parametrelerin kritik eşik değerleri ile ilgili yaptıkları çalışmada, kolinesteraz değerini ketozisli ineklerde kontrol grubuna göre düşük bulmuşlar ve yaptıkları çalışma sonucunda kolinesterazın karaciğer fonksiyonlarını denetleme ve ketozis riskinin tahmininde faydalı olabileceğini bildirmişlerdir 23 . Klinik ketozisli ineklerde asetilkolinesteraz düzeyinin kontrol grubuna göre önemli derecede düşük olduğunu gözlemişlerdir 24 . Bu çalışmada botulismuslu ineklerde kolinesterazın sağlıklı ineklere göre azaldığı fakat anlamlı çıkmadığı tespit edildi.…”

Section: Biyokimyasal Bulgularunclassified

Evaluation Of Serum Cholinesterase And Amyloid A Levels İn Cows With Botulism

Aytekin¹,

Kaya²

2017

BSBD

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Bu ça l ışmada botulismuslu ve sağlıklı ineklerde s erum kolinesteraz, amiloi d A, a l bumi n, tota l protei n, tota l bi l i rubi n, üre, GGT ve SDH a ra ştırıl dı. YÖNTEM ve GEREÇLER: Ça l ışma ve kontrol grubunu gebe ve kuru dönemde i ki i l e beş ya şl a rı a ra s ında deği şen 10 a det botul i s mus l u ve 6 a det s a ğl ıkl ı hol şta yn i nek ol uşturdu. Pa ra metreleri n s erum düzeyl eri Nefel ometre BNII ve otoa na l i zör kul l a nıl a ra k öl çül dü. Boti lusmuslu hayva nl a rın ka n s eruml a rında n ve s i l a jda n fa re i nokul a s yon tes ti ya pıl dı. BULGULAR: Botul ismuslu i neklerin kan serumlarında ve sila jda Clostridium botulinum ti p C ve ti p D toksini tespit edildi. Serum, kolinesteraz, a miloid A, a lbumin, total protein, total bili rubi n ve SDH botulismuslu ve sağlıklı i neklerde önemli bir deği şi kl i k gös termezken botul i s mus l u i nekl erde üre ve GGT düşük çıktı. TARTIŞMA ve SONUÇ: Botul i s mus l u i nekl erde kol i nes tera z ve forml a rının a ra ştırıl ma s ı botul i s mus un fi zyopa tol oji s i ne ve prognozuna fa yda l ı ol a bi l eceği s onucuna va rıl dı. Anahtar Kelimeler: Botul i s mus , i nek, kol i nes tera z, s erum a mi l oi d A, toks i n SUMMARY INTRODUCTION:The a im of this study was to determine s e rum chol i nes tera s e, a myl oi d A, a l bumin, total protein, total bilirubin, urea, GGT a nd SDH in cows wi th or wi thout botul i s m. METHODS: The s tudy i ncluded 10 holstein cows aged two to five years as the botul i s m group a nd control group consisting of 6 healthy cows. Serum concentra ti on of a l l the pa ra meters were measured using an a utoanalyzer a nd Nefelometre equipment BNII. Mi ce inoculation tes t wa s performed i n s i l a ge a nd bl ood tha t cows wi th botul i s m. RESULTS: Clostridium botulinum type C a nd D toxi ns were determined i n silage a nd blood tha t cows wi th botulism. Serum cholinesterase, a myl oid A, a lbumin, total protei n, tota l bi l i rubi n a nd SDH did not differ significantly between two groups. Serum showed that i n the botul i s m group urea a nd GGT were l ower tha n i n the control group. DISCUSSION AND CONCLUSION: Serum cholinesterase and forms researched tha t ma y prove benefi ci a l phys i opa thol ogy a nd prognos i s of botul i s m.

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“…Moreover, the liver synthetic capability was evaluated, and TP was measured in the blood, with a low profile. TP is another blood parameter used to measure liver synthetic capability, because it is manufactured only in the liver [25]. Hp concentration was also evaluated; it was increased in all infected animals, where serum Hp indicates several inflammation types in cattle [26,27].…”

Section: Discussionmentioning

confidence: 99%

Hepatic biomarkers and coprology as indicators of clinical bovine fasciolosis in Chad

et al. 2021

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Background and Aim: Fasciolosis is a cosmopolitan parasitic disease of food-producing animals and is typically caused by digenetic trematodes, Fasciola gigantica and Fasciola hepatica. It has a direct negative impact on the liver and consequently affects liver metabolism. It has indirect effects, including lowered milk production and effects on quality and general health conditions leading to extensive economic losses. This study aimed to focus on the link between clinical fasciolosis and some biochemical analysis of the hepatic profile of cattle in Chad. Materials and Methods: This study was initiated in response to emerging complaints from dairy cattle owners detecting a bitter milk cream and butter taste. Furthermore, those animals had shown poor health conditions by presenting with diarrhea. Preliminary surveillance for possible causes was performed, including fecal and serum biochemical analyses and clinical observation to diagnose the possible disease. Results: The results obtained, including the finding of parasite stages during the coprological examination, confirmed the role of fasciolosis. The independent sample t-test indicated highly significantly altered values of all biochemical liver indicators in the infected animals. All animals were treated with two doses of rafoxanide (3 mg/kg b.w.) S/C, at 21 days intervals, with vitamin supplements, mineral mixtures, and food additives. Surprisingly, the main complaint was restored after treatment. This is another evident clue of fasciolosis. To the best of our knowledge, this is the first recent study that diagnosed fasciolosis in Chad. Conclusion: This study emphasized the importance of fasciolosis, its negative impact on milk taste, and the necessity for veterinary advice regarding routine examination and prophylactic measures, especially before autumn, to minimize economic losses. However, regardless of the small sample size, this study could serve as a cornerstone for future studies on evaluating the accurate epidemiological status of fasciolosis in Chad. This study reported a close association between the alteration of liver enzymes and total protein levels in fasciolosis and the bitter milk cream taste, which could be used as a diagnostic tool for fasciolosis.

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Critical thresholds of liver function parameters for ketosis prediction in dairy cows using receiver operating characteristic (ROC) analysis

Cited by 34 publications

References 28 publications

Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis

Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis

Evaluation Of Serum Cholinesterase And Amyloid A Levels İn Cows With Botulism

Hepatic biomarkers and coprology as indicators of clinical bovine fasciolosis in Chad

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