Crocin Alleviates 5-Fluorouracil-induced Hepatotoxicity through the abrogation of Oxidative Stress in Male Wistar rats

Toxic Effects of Methotrexate on Rat Kidney Recovered by Crocin as a Consequence of Antioxidant Activity and Lipid Peroxidation Prevention

“…Crocin stabilizes the cell membranes by preventing lipid peroxidation [ 8 ] . Similar to our results, Afolabi and Ugbaja [ 39 ] observed that crocin significantly decreases liver enzymes. Our study showed that MTX-induced renal damage in rats could be reduced by herbal antioxidants such as crocin.…”

Nephroprotective Potential of Alpha Lipoic Acid in 5-Fluorouracil-Induced Toxicity of Wistar Rats

“…Histological examination of the kidney showed that 5-FU treatment caused abnormal ultrastructural alterations in these organs. This is consistent with the Afolabi et al 2 In ALA treated animals, the changes were less compared to the 5-FU group, showing that ALA administration could improve the changes brought about by the drug on the kidney. Abidem et al 23 also previously reported that Photomicrographs from the kidney samples showed cortical necrosis and thin glomeruli basement membrane caused by 5-FU and signs of local hemorrhage due to 5-FU.…”

“…1 5-Fluorouracil (5-FU) is a fluoropyrimidine antimetabolite agent that plays a significant role in the treatment of cancers. 2 5-Fluorouracil (5-FU) is a chemotherapeutic agent that functions throughout the S phase of the cell cycle.In the cancerous cell, it interferes with nucleoside metabolism and is incorporated into ribonucleic acid (RNA) and deoxyribonucleic acid (DNA), resulting in cytotoxicity and cell death. 2 5-FU, thymidine phosphorylase activates thromidylate synthase inhibiting fluorodeoxyuridine, thus preventing DNA synthesis.This leads to cell growth and ultimately cell death.…”

Effects of Virgin Coconut Oil and Lauric Acid “With or Without 5-Fluorouracil” on Dimethylhydrazine-Induced Hepatotoxicity in Male Rats

“…The 5-FU induced an increase in the amount of ROS and the level of MDA in the liver tissues [32] . A reduction in the activity of vital antioxidant enzymes (including SOD and CAT) in the liver was also demonstrated following treatment with 5-FU [33] . Earlier report revealed that the enhancing levels of tissue lipid peroxidation, along with the lowering of tissue SOD and CAT activities, indicated an increase in the oxidative stress during DMH-induced carcinogenesis [34] .…”