Crocin Improves Diabetes-Induced Oxidative Stress via Downregulating the Nox-4 in Myocardium of Diabetic Rats

Yaribeygi, Habib; Maleki, Mina; Mohammadi, Mohammad Taghi; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1007/978-3-030-73234-9_18

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…Several natural compounds are well‐known to show therapeutic effects against DCM. For example, crocin, mangiferin and kaempferol ameliorate diabetes‐induced cardiac injuries and improve cardiac function in different DCM models 18–20 . These effects are mainly attributed to their anti‐inflammatory and antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

“…We speculate that the cardioprotective effect of Cos may be partly attributed to its anti‐apoptotic effect. Moreover, studies have shown that Cos suppresses apoptosis of tumour cells in various tumour models 20,47,48 . Mao et al have reported the anti‐apoptotic capability of Cos in LPS‐induced acute lung injury, 45 indicating the anti‐apoptotic potential of Cos in inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, studies have shown that Cos suppresses apoptosis of tumour cells in various tumour models. 20,47,48 inhibit the interaction between TAK1 and TAB1. 42 In addition, IKKβ may be another target of Cos, given that Cos inhibits LPS-induced BV2 microglial inflammation by inhibiting the IKKβ/NF-κB signalling pathway.…”

Section: Discussionmentioning

confidence: 99%

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Costunolide alleviates hyperglycaemia‐induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress

Jin

Chen

Wang

et al. 2023

J Cellular Molecular Medi

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Diabetes mellitus (DM) is a common metabolic disorder worldwide and has gradually become an epidemic in recent years. Elevated blood glucose levels typically cause a series of tissue injury-related events during diabetes, resulting in diabetic complications such as diabetic cardiomyopathy (DCM), diabetic nephropathy, diabetic foot disease and retinopathy. Among these diabetic complications, DCM is considered a risk factor of heart failure, known to be associated with disability and mortality in patients with diabetes. 1 DCM persistently presents as diastolic dysfunction during the early stage, progressing to systolic dysfunction in the advanced phase.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Costunolide alleviates hyperglycaemia‐induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress

Jin

Chen

Wang

et al. 2023

J Cellular Molecular Medi

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“…Previous studies showed that crocin has a considerable anti-inflammatory and antioxidant potency ( Li et al, 2018 ; Korani et al, 2019 ; Yaribeygi et al, 2021 ). In addition, combined treatment with GA and TP increase efficacy while decreasing toxicity in RA treatment ( Tai et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy

Yan

Zhang

et al. 2022

Front. Pharmacol.

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Clinical use of triptolide (TP) is restricted due to severe toxicity. This study assessed the protective effect of crocin (CR) as a natural antioxidant against TP-induced toxicity in bovine collagen type II-induced arthritis (CIA) in mice. The mice in the CIA model group showed macroscopic signs of severe arthritis. The anti-arthritis effects in the control, TP + CR, and TP groups were evaluated through assessment of foot volume, arthritis score, and proinflammatory cytokines, and collagen antibody assay. Crocin reduced TP-induced toxicity, as evidenced by evaluation of survival rate, body weight, visceral index, hepatic and renal functions, histopathologic analyses, and antioxidant enzyme activities. Transcriptome sequencing resulted in identification of 76 differentially expressed genes (DEGs) associated with hepatotoxicity between the TP and TP + CR groups. Of these, Three DEGs (Cyp1a2,Gsta4, and Gstp1) were validated using quantitative real-time PCR analysis. In conclusion, CR protected CIA mice from TP-induced toxicity through modulation of the cytochrome P450 and glutathione metabolism pathways.

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Crocin-loaded nanoliposomes: Preparation, characterization, and evaluation of anti-inflammatory effects in an experimental model of adjuvant-induced arthritis

Mohammadi

Korani

Nemati

et al. 2022

Journal of Drug Delivery Science and Technology

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Crocin Improves Diabetes-Induced Oxidative Stress via Downregulating the Nox-4 in Myocardium of Diabetic Rats

Cited by 4 publications

References 37 publications

Costunolide alleviates hyperglycaemia‐induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress

Costunolide alleviates hyperglycaemia‐induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress

The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy

Crocin-loaded nanoliposomes: Preparation, characterization, and evaluation of anti-inflammatory effects in an experimental model of adjuvant-induced arthritis

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