Crohn's Disease in a Defined Population

Brahme, Folke; Lindström, C; Wenckert, A

doi:10.1016/s0016-5085(19)32575-2

Cited by 190 publications

(13 citation statements)

References 19 publications

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“…An incidence variation of five to seven per 10 5 inhabitants was found between three different areas in Sweden (Malmö,22 Uppsala,3 and Örebro6). The incidence rate in this study is lower than in any of those studies even though registers of inpatients, outpatients and private gastroenterologists were reviewed.…”

Section: Discussionmentioning

confidence: 92%

Incidence of Crohn’s disease in Stockholm County 1955–1989

Lapidus

Bernell

Hellers

et al. 1997

Gut

137

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Aim-To evaluate the incidence of Crohn's disease in Stockholm County between 1955 and 1989. Methods-A cohort of 1936 patients with Crohn's disease was retrospectively assembled. Incidence rates and changes in disease distribution were assessed. Results-The mean increase in incidence was 15% (95% confidence intervals 12% to 18%) per five year period with a mean annual incidence rate at 4.6/10 5 during the last two decades. The mean incidence for the entire study period was similar for men and women. The mean age at diagnosis increased from 25 years in 1960-64 to 32 years in 1985-89, partly because of an increasing proportion of patients aged at least 60 years at diagnosis. The proportion of patients with colonic Crohn's disease at the time of diagnosis increased from 15% to 32% (17% diVerence; 95% confidence intervals 12% to 23%) whereas the proportion of patients with ileocaecal disease decreased from 58% to 41% (17% difference; 95% confidence intervals 10% to 24%) during the study period. Elderly patients had a higher proportion of small bowel disease and a lower proportion of ileocolonic disease compared with the younger patients. Conclusion-The incidence rate of Crohn's disease in Stockholm has stabilised at 4.6/10 5 and the proportion of elderly patients has increased during a 35 year period. Colonic Crohn's disease has increased in frequency with a reciprocal decrease in ileocaecal disease. (Gut 1997; 41: 480-486)

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Section: Discussionmentioning

confidence: 92%

Incidence of Crohn’s disease in Stockholm County 1955–1989

Lapidus

Bernell

Hellers

et al. 1997

Gut

137

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“…However, only a proper epidemiological survey would provide convincing evidence. Experience in Aberdeen, Malmo, Nottingham, and Uppsala suggests that the disease is increasing (Norlen et al, 1970;Kyle, 1972, Miller et al, 1974Brahme et al, 1975). In Oxford, there has been no further epidemiological study since the one made by Evans and Acheson (1965) and some doubt must remain until another epidemiological study has been made.…”

Section: Discussionmentioning

confidence: 99%

Course and prognosis of Crohn's disease.

Truelove¹,

Peña²

1976

Gut

165

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“…Most studies of the epidemiology of inflammatory bowel disease (IBD) are retrospective and include hospitalized patients only (1)(2)(3)(4)(5)(6). Thus, the incidence data reflect the most severely ill patients.…”

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confidence: 99%

Epidemiology of Crohn's Disease in Western Norway

Haug

Schrumpf

Halvorsen

et al. 1989

Scandinavian Journal of Gastroenterology

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The incidence of Crohn's disease in western Norway was estimated in a prospective epidemiologic study during the years 1984 and 1985. The total population in the area was 807,000. Both inpatients and outpatients were included. Five hundred and fifty general practitioners and 12 hospitals participated in the study. A total of 86 patients were diagnosed, giving a mean annual incidence of 5.3 per 100,000. For patients between 15 and 19 years of age-specific incidence rate was 16.0 The M/F sex ratio was 0.9. In the same period 240 patients with ulcerative colitis were diagnosed (mean annual incidence, 14.8 per 100,000), giving a ratio of 2.8 between ulcerative colitis and Crohn's disease and an annual incidence of 20.1 per 100,000 for inflammatory bowel disease. Familial occurrence of IBD was found for 12% of the patients.

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Crohn's Disease in a Defined Population

Cited by 190 publications

References 19 publications

Incidence of Crohn’s disease in Stockholm County 1955–1989

Incidence of Crohn’s disease in Stockholm County 1955–1989

Course and prognosis of Crohn's disease.

Epidemiology of Crohn's Disease in Western Norway

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