Cross-sectional study of neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in mood disorders

Mazza, Mario Gennaro; Tringali, A.; Rossetti, Aurora; Botti, Rossana Eugenia; Clerici, Massimo

doi:10.1016/j.genhosppsych.2019.02.003

Cited by 64 publications

(57 citation statements)

References 41 publications

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“…Ikbal et al found that MLR was higher in patients in the manic state of bipolar disorder than the control group [22]. Mario et al found higher MLR in both major depression disorder and the depressive phase bipolar disorder than in the bipolar disorder manic phase [23]. These results were similar to those of our study, in that the high value of MLR was associated with elevated risk of depression.…”

Section: Discussionsupporting

confidence: 90%

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The monocyte-to-lymphocyte ratio and depression in diabetes patients

Zhou¹,

Wang²,

Li³

2020

Preprint

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Background: The purpose of this study was to determine the association between The monocyte-to-lymphocyte ratio (MLR) and depression with diabetes mellitus.Method: We examined data from the US National Health and Nutrition Examination Survey from 2009 to 2016. Cox proportional hazard models were used to calculate the associations between MLR and depression. For precise investigation of the relationship, we also plotted the smooth curve fit and generated a two-piecewise linear regression model using the penalized spline method.Result: We enrolled 2820 diabetes patients in the database. Diabetes patients who had high MLR tended to be young, female, obese, unmarried, and had low levels of education. For tertile analysis, the ORs and 95% CIs of clinically relevant depression in tertile analysis were 1.03 (0.91, 1.17) for the second group and 1.62 (1.44, 1.82) for the third group in the unadjusted model compared to the control group. A similar trend was observed for the adjusted model and the quartiles analysis. We found the inflection point of MLR was 2.7. There is a positive association between MLR and depression above the threshold, and no relationship was found when MLR was below the threshold in diabetes patients. Conclusion: There is a nonlinear relationship between MLR and depression in diabetes patients. High level of MLR more than the inflection point may add prognostic information for depression in diabetes patients.

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Section: Discussionsupporting

confidence: 90%

“…They were more likely to have high levels of triglycerides and RDW, low levels of HDL, and higher risk of co-morbid DR and depression. -9): No for minimum to mild (0-9), Yes for moderate to severe (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Characteristics Of Enrolled Participantsmentioning

confidence: 99%

The monocyte-to-lymphocyte ratio and depression in diabetes patients

Zhou¹,

Wang²,

Li³

2020

Preprint

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“…The relationship between psychiatric diseases and monocyte activation have also been studied previously. 6 The aims of this study were to compare the ratios of neutrophilto-lymphocyte to monocyte-to-lymphocyte and platelet-tolymphocyte of patients with acute rheumatic fever and healthy children, and to correlate them with the other well-known inflammatory parameters.…”

Section: Introductionmentioning

confidence: 99%

Are there any novel markers in acute rheumatic fever: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio

Giray

Hallioglu

2020

Cardiol Young

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Objective:The aim of this study was to investigate the relationship between C-reactive protein and erythrocyte sedimentation rate and neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios in acute rheumatic fever in children.Method:In this retrospective study, 182 patients with acute rheumatic fever and 173 controls were included. Complete blood count parameters, and neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were recorded for all the patients underwent transthoracic echocardiography.Results:Neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were significantly higher in patients with rheumatic heart disease than patients without cardiac involvement (p < 0.05). C-reactive protein and erythrocyte sedimentation rate levels were found to have a positive correlation with neutrophil-to-lymphocyte (r = 0.228, p = 0.001; r = 0.355, p = 0.001), platelet-to-lymphocyte (r = 0.227, p = 0.01; r = 0.149, p = 0.005), and monocyte-to-lymphocyte ratios (r = 0.117, p = 0.005; r = 0.107, p = 0.044). Cardiac involvement was present in 152 (83.5%) of the patients. Neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were significantly higher in patients with rheumatic heart disease than patients without cardiac involvement (p < 0.05). Patients with carditis were grouped according to mitral, aortic, or both valve involvement but there was no significant difference between the groups with respect to neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios. In addition, neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios were significantly higher in patients with Sydenham’s chorea than without chorea (p < 0.05).Conclusion:Neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios may help make the diagnosis of acute rheumatic fever and its prognosis by serial measurements in follow-up but none of them tell us the severity of carditis. Also, this is the first study showing the positive correlation between Sydenham’s chorea and neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios. Further studies are needed to confirm this hypothesis, as this is the first study in the literature on this topic.

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“…5 True transdiagnostic studies are rare with only three studies to date comparing NLR between psychiatric diagnoses. [15][16][17] Of the NLR studies comparing different psychiatric diagnoses, Ozdin et al reported that patients with schizophrenia, experiencing a psychotic episode, had higher NLR than patients with manic-phase BD, suggesting that there are detectable differences in NLR across diagnosis and symptomatology. 15 Mazza et al found that patients with manic-phase BD had higher NLR than patients with major depressive disorder (MDD).…”

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confidence: 99%

Neutrophil–lymphocyte ratio across psychiatric diagnoses: a cross-sectional study using electronic health records

Brinn

Stone

2020

BMJ Open

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ObjectivesThe main objective of this study was to compare neutrophil–lymphocyte ratio (NLR), a marker of systemic inflammation, between patients diagnosed with International Classification of Diseases 10th Revision (ICD-10) psychiatric disorders and control participants.DesignA cross-sectional methodology was employed to retrospectively analyse electronic health records and records derived from a national health survey.SettingA secondary mental healthcare service consisting of four boroughs in South London.ParticipantsA diverse sample of 13 888 psychiatric patients extracted from South London and Maudsley electronic health records database and 3920 control participants extracted from National Health and Nutrition Survey (2015–2016) were included in the study.Primary and secondary outcome measuresPrimary: NLR levels in patients with mental health diagnoses, NLR between patients with different mental health diagnoses. Secondary: relationship of NLR to length of hospitalisation and to mortality.ResultsNLR was elevated compared with controls in patients with diagnoses including dementia, alcohol dependence, schizophrenia, bipolar affective disorder, depression, non-phobic anxiety disorders and mild mental retardation (p<0.05). NLR also correlated with age, antipsychotic use and hypnotic use. NLR was found to be higher in individuals of ‘white’ ethnicity and lower in individuals of ‘black’ ethnicity. Elevated NLR was associated with increased mortality (β=0.103, p=2.9e−08) but not with hospital admissions or face-to-face contacts.ConclusionsElevated NLR may reflect a transdiagnostic pathological process occurring in a subpopulation of psychiatric patients. NLR may be useful to identify and stratify patients who could benefit from adjunctive anti-inflammatory treatment.

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Cross-sectional study of neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in mood disorders

Cited by 64 publications

References 41 publications

The monocyte-to-lymphocyte ratio and depression in diabetes patients

The monocyte-to-lymphocyte ratio and depression in diabetes patients

Are there any novel markers in acute rheumatic fever: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio

Neutrophil–lymphocyte ratio across psychiatric diagnoses: a cross-sectional study using electronic health records

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