Crosstalk between angiogenesis, cytokeratin-18, and insulinresistance in the progression of non-alcoholic steatohepatitis

Abstract

These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH.

Hepatic fibrosis developing in morbid obesity independent of steatohepatitis: new mechanism or the Rube Goldberg machine?

“…The finding that angiogenic mechanisms are activated in bland steatosis contrasts with other data on NAFLD [12,13]. The current manuscript differs from other studies with the finding observed in those with morbid obesity, a population not included in the contrasting studies.…”

“…In human tissue, angiogenesis, measured by CD 34-positive staining cells, occurred in NASH, but not normal liver or bland steatosis [12,13]. Angiogenesis in NASH was associated with both hepatocellular apoptosis and insulin resistance [13]. The association between hepatic inflammation and angiogenesis is not unique to NAFLD.…”

“…In animal models of steatohepatitis, the expression of vascular endothelial growth factor (VEGF) and angiogenesis occurred in parallel to fibrosis and carcinogenesis [11]. In human tissue, angiogenesis, measured by CD 34-positive staining cells, occurred in NASH, but not normal liver or bland steatosis [12,13]. Angiogenesis in NASH was associated with both hepatocellular apoptosis and insulin resistance [13].…”

A composite model including visfatin, tissue polypeptide-specific antigen, hyaluronic acid , and hematological variables for the diagnosis of moderate-to-severe fibrosis in nonalcoholic fatty liver disease: a preliminary study

“…Recently, it has been shown that serum CK18 levels correlate with hepatic angiogenesis, which is a necessary step for the development of fibrosis. 27 In our study, waist circumference, but not BMI, was associated with advanced fibrosis, thus showing that mesenteric fat is a more important predictor of significant fibrosis than body weight, which again emphasizes the metabolic role of visceral adipose tissue.…”

Clinical features of nonalcoholic fatty liver disease assoсiated with type 2 diabetes

“…Значительный фиброз при НАЖБП и СД2 отмечают и другие авторы (Doycheva, 2016). При воспалении активируется неоангиогенез, перестраивается сосудистая архитектоника печени (Kitade, 2009;Gill, 2011). Данные процессы ответственны за формирование портальной гипертензии при НАЖБП.…”