Cryochemical Synthesis of Polymorphous Nanostructures of a Steroid Neurohormone

Morozov, Yurii N.; Chistyakov, Dmitry V.; Чернышев, Владимир В.; Sergeev, G. B.

doi:10.3390/molecules22081378

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…In synthesizing and studying drug polymorphism, new possibilities have been opened up in light of an original strategy proposed in [41][42][43][44][45]. The developed technology is based on the conversion of the initial substance into a gaseous state in the course of its sublimation within the flow of an inert gas-carrier, followed by condensation on contact with a surface cooled by liquid nitrogen.…”

Section: Approaches For the Synthesis Of New Polymorphic Nanostructuresmentioning

confidence: 99%

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The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs

Chistyakov

Sergeev

2020

Pharmaceutics

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Among the significant problems of modern pharmacology are the low solubility and bioavailability of drugs. One way to resolve this problem is to obtain new polymorphic forms of drugs with improved physicochemical properties. Various approaches have been developed with this aim, including the preparation of co-crystals, the use of nanoparticles, or the use of compounds in the form of a salt. A promising direction in pharmacology concerns the production of new stable polymorphic structures. In this mini-review, we consider certain aspects of drug polymorphism, methods for the synthesis of polymorphs, and the stability, size, and transformation of crystalline polymorphs. Moreover, we summarize our results from several studies demonstrating the problems associated with the synthesis of new polymorphous modifications based on inert gases and cryotemperatures. The results indicate that the problems specific to drug polymorphisms have only been partly resolved, are of current interest, and require further development.

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Section: Approaches For the Synthesis Of New Polymorphic Nanostructuresmentioning

confidence: 99%

“…These are substances that have an oxygen, Figure 1. Nanostructure synthesis block-scheme (adapted from [44]).…”

Section: Effect Of Inert Gases On the Synthesis Of New Polymorphous Nmentioning

confidence: 99%

The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs

Chistyakov

Sergeev

2020

Pharmaceutics

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Methods for nanoparticle synthesis and drug delivery

Choudhury¹,

Paul²,

Goswami³

et al. 2022

Advances in Nanotechnology-Based Drug Delivery Systems

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Novel Approaches for the Synthesis of Nanomaterials for Nanodevices in Medical Diagnostics

Puri

2024

Applications of Nanoparticles in Drug Delivery and Therapeutics

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In recent years, the field of nanotechnology has witnessed significant advancements in the synthesis of nanomaterials tailored for applications in medical diagnostics. Nanodevices, characterized by their miniature size and exceptional properties, hold tremendous potential for revolutionizing healthcare by enabling rapid and precise diagnosis of various diseases. This chapter provides an overview of innovative strategies employed in the synthesis of nanomaterials specifically designed for integration into nanodevices for medical diagnostics. The synthesis of nanomaterials for nanodevices necessitates the development of precise and reproducible methods capable of producing materials with desired properties such as size, shape, composition, and surface functionalization. Traditional synthesis techniques, including chemical vapor deposition, sol-gel processes, and physical vapor deposition, have been augmented by novel approaches leveraging principles from chemistry, physics, and materials science. One such approach is bottom-up synthesis, which involves the self-assembly of atoms or molecules into nanoscale structures, enabling precise control over size and morphology. Techniques such as molecular beam epitaxy (MBE) and atomic layer deposition (ALD) offer atomic-level precision, facilitating the fabrication of nanomaterials with tailored properties for specific diagnostic applications. Additionally, advancements in nanomaterial synthesis have been driven by the emergence of green synthesis methods, which utilize natural sources such as plants, microbes, and biomolecules to produce nanomaterials with minimal environmental impact. Green synthesis techniques not only offer a sustainable alternative to conventional methods but also afford opportunities for the development of biocompatible and biofunctionalized nanomaterials suitable for biomedical applications. Furthermore, the integration of nanomaterials into functional nanodevices requires precise control over material properties to ensure compatibility with diagnostic platforms. Surface modification techniques, including functionalization with biomolecules, polymers, and ligands, play a crucial role in enhancing the stability, biocompatibility, and targeting capabilities of nanomaterials for diagnostic applications. The chapter also discusses recent advancements in the synthesis of multifunctional nanomaterials capable of simultaneous detection, imaging, and therapy, offering integrated solutions for personalized medicine and point-of-care diagnostics. By harnessing the synergistic properties of nanomaterials, researchers are developing next-generation nanodevices capable of revolutionizing medical diagnostics by providing rapid, sensitive, and cost-effective solutions for disease detection and monitoring.

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Cryochemical Synthesis of Polymorphous Nanostructures of a Steroid Neurohormone

Cited by 4 publications

References 16 publications

The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs

The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs

Methods for nanoparticle synthesis and drug delivery

Novel Approaches for the Synthesis of Nanomaterials for Nanodevices in Medical Diagnostics

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