Cryogelation of xanthan

Giannouli, Persephoni; Morris, Edwin R.

doi:10.1016/s0268-005x(03)00019-5

Cited by 150 publications

(69 citation statements)

References 32 publications

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“…The mechanism involves the formation of microcrystals in the structure due to freeze-thawing. Examples of this type of gelation are freeze-thawed gels of polyvinyl alcohol and xanthan (Giannouli & Morris, 2003;Hoffman, 2002;.…”

Section: Freeze-thawingmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

259

178

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Section: Freeze-thawingmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

259

178

View full text Add to dashboard Cite

“…Other hydrogels prepared from monomers such as 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate were also used for cell entrapment [74,75]. Another interesting cryogel for biotechnological applications can be prepared from xanthan and used for fabrication of artificial organs, cell entrapment, and in food technology [76].…”

Section: Cryogel As Adsorbents For Bioseparation and Bioconversionmentioning

confidence: 99%

Monoliths for fast bioseparation and bioconversion and their applications in biotechnology

Jungbauer¹,

Hahn

2004

J of Separation Science

161

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Monoliths have consolidated their position in bioseparation. More than 200 different applications have been reported in the past two decades and their advantages compared to conventional chromatography demonstrated. These include the high mass transfer efficiency due to the convective flow enabled by the macroporous character of the matrix. Recently plasmid DNA and viruses were separated with high efficiency and cryogels and monolithic superporous agarose were developed for capture of proteins from crude homogenates and separation of microorganisms or lymphocytes. Currently four companies manufacture monoliths mainly for analytical applications although monoliths with a volume of 0.8 liter are commercially available and 8 L are available as prototypes. A book entitled "Monolithic materials: preparation, properties and applications" was published in 2003 and became standard reference of the status of this area. This review focuses on the progress in monoliths that goes beyond the scope of this reference book. Less progress has been made in the field of bioconversions in spite of the fact that monolithic supports exhibit better performance than beads in enzymatic processing of macromolecules. It appears that the scientific community has not yet realized that supports for these applications are readily available. In addition, monoliths will further substantially advance bioseparations of both small and large molecules in the future.

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“…The polymer gel phase is formed during one of the stages of the cryogenic treatment: during freezing of the initial system, during storage of the samples in the frozen state or during thawing of the frozen specimens. (1, [3][4][5][6] Recently, the structuring of different polymers by applying a cryogenic treatment has attracted a lot of attention, as indicated by the following examples. For a thiol-containing poly(acryl amide) derivative, the conditions were optimized in order to obtain an insoluble gel after freezing-thawing.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cryogenic Treatment on the Rheological Properties of Gelatin Hydrogels

Vlierberghe

Dubruel

Schacht

2010

Journal of Bioactive and Compatible Polymers

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Above the critical gelation concentration, gelatin has the ability to form a gel when cooled below the sol-gel temperature. In the present work, freeze-thaw cycles were implemented on gelatin solutions possessing varying concentrations. The rheological properties of the cryogels developed were compared with hydrogels formed at room temperature. The results indicated that the rheological properties of cryogels were superior to those of the corresponding hydrogels formed at room temperature. In addition, the critical gelation concentration decreased after (repeated) cryo-treatment(s). The effect of applying various (cryo)parameters, including the number of freeze-thaw cycles, the cooling rate, the thawing rate and the gelatin concentration, on the final material properties was examined. The rheological properties of the cryogels improved with an increasing number of cryo-cycles and a decreasing cooling and thawing rate. In a second part of the work, methacrylamide-modified gelatin was treated cryogenically, followed by in situ UV-irradiation to enable radical crosslinking. It was shown that the crosslinking efficiency improved upon freeze-thawing. The latter was however limited by the gelatin concentration, which affects the chain mobility required to induce phase separation. The present work demonstrates that cryogelation offers possibilities to finetune the mechanical properties of hydrogels. The observed findings are of relevance for the field of tissue engineering, since this concept was previously applied for the development of porous gelatin hydrogels as biomaterials. In addition, a cryogenic treatment can be applied to a wide range of synthetic and natural polymers.-3 -

show abstract

Cryogelation of xanthan

Cited by 150 publications

References 32 publications

Hydrogels: Methods of Preparation, Characterisation and Applications

Hydrogels: Methods of Preparation, Characterisation and Applications

Monoliths for fast bioseparation and bioconversion and their applications in biotechnology

Effect of Cryogenic Treatment on the Rheological Properties of Gelatin Hydrogels

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