Cryoglobulin types and rheumatoid factors associated with clinical manifestations in patients with hepatitis C virus infection

Schistosoma mansoni coinfection could have a protective effect against mixed cryoglobulinaemia in hepatitis C patients

“…These discrepancies can be attributed to bias in patient selection, the bias resulting from c 2009 The Authors. Journal compilation c 2009 Blackwell Publishing Ltd the increased incidence of advanced liver disease and cirrhosis in patients selected from gastroenterology services compared with patients presenting with vasculitic symptoms (43). The intrahepatic Th1 polarization in MC has been suggested by some authors (18) to account for a milder course of liver disease and by others (19) to account for a more severe course of liver disease.…”

Insulin resistance and low-density apolipoprotein B-associated lipoviral particles in hepatitis C virus genotype 1 infection

“…The plasma was separated by centrifugation at 3000 rpm for 10 min at 37°C in a Rotanta 460R Hettich centrifuge (DJB Labcare, Buckinghamshire, UK). The blood was handled as close to body temperature as possible to avoid the formation of a cryoglobulin precipitate 18. Complete protease inhibitor cocktail (Roche Products Ltd, Welwyn Garden City, UK) was added to the plasma to prevent protein degradation.…”

Pegylated interferon-α, ribavirin, and rituximab combined therapy of hepatitis C virus–related mixed cryoglobulinemia: a long-term study

“…Single (type I) cryoglobulins consist of a monoclonal immunoglobulin (Ig), whereas mixed cryoglobulins include 2 or more Ig isotypes, with (type II) or without (type III) a monoclonal component. 2 Thus, mixed cryoglobulinemia (MC) is an immune complex-mediated systemic vasculitis, typically involving small and medium-sized vessels. Its clinical manifestations, however, occur in a low proportion of HCV-positive patients with cold-precipitable proteins.…”