CRYPTOCOCCAL ANTIGENEMIA IN HIV/AIDS PATIENTS USING LATERAL FLOW IMMUNOASSAY DETECTION AT Dr. SOETOMO GENERAL HOSPITAL SURABAYA

Widjaja, Sajuni; Triyono, Erwin Astha; Kawilarang, Arthur Pohan; Rohiman, Abu

doi:10.20473/ijtid.v7i1.6311

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…By using antigen detection, a higher diagnostic sensitivity and incidence is obtained 42,43 . Four studies on the detection of antigenaemia among ART naïve HIV patients conducted in Jakarta, Bandung, Surabaya showed the prevalence of antigenaemia varied between 6.4%–7.3% 41,42,69 . Another study conducted in Pontianak, Kalimantan (Borneo) found the prevalence of antigenaemia to be 5.6% among HIV‐infected patients 70 .…”

Section: Discussionmentioning

confidence: 99%

“…42,43 Four studies on the detection of antigenaemia among ART naïve HIV patients conducted in Jakarta, Bandung, Surabaya showed the prevalence of antigenaemia varied between 6.4%-7.3%. 41,42,69 Another study conducted in Pontianak, Kalimantan (Borneo) found the prevalence of antigenaemia to be 5.6% among HIV-infected patients. 70 In our department, we recorded cases of cryptococcosis in non-HIV patients.…”

Section: Cryptococcosismentioning

confidence: 99%

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Serious fungal disease incidence and prevalence in Indonesia

Wahyuningsih

Adawiyah

Sjam

et al. 2021

Mycoses

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Background Indonesia is a tropical country, warm and humid, with numerous environmental fungi. Data on fungal disease burden help policymakers and clinicians. Objectives We have estimated the incidence and prevalence of serious fungal diseases. Methods We found all published and unpublished data and estimated the incidence and prevalence of fungal diseases based on populations at risk. HIV data were derived from UNAIDS (2017), pulmonary tuberculosis (PTB) data from 2013–2019, data on chronic pulmonary aspergillosis (CPA) were used to estimate CPA prevalence and likely deaths, COPD data from Hammond (2020), lung cancer incidence was from Globocan 2018, and fungal rhinosinusitis was estimated using community data from India. Results Overall ~7.7 million Indonesians (2.89%) have a serious fungal infection each year. The annual incidence of cryptococcosis in AIDS was 7,540. Pneumocystis pneumonia incidence was estimated at 15,400 in HIV and an equal number in non‐HIV patients. An estimated 1% and 0.2% of new AIDS patients have disseminated histoplasmosis or Talaromyces marneffei infection. The incidence of candidaemia is 26,710. The annual incidence of invasive aspergillosis was estimated at 49,500 and the prevalence of CPA is at 378,700 cases. Allergic bronchopulmonary aspergillosis prevalence in adults is estimated at 336,200, severe asthma with fungal sensitisation at 443,800, and fungal rhinosinusitis at 294,000. Recurrent vulvovaginal candidiasis is estimated at 5 million/year (15–50 years old). The incidence of fungal keratitis around 40,050. Tinea capitis prevalence in schoolchildren about 729,000. Conclusions Indonesia has a high burden of fungal infections.

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Section: Discussionmentioning

confidence: 99%

Section: Cryptococcosismentioning

confidence: 99%

Serious fungal disease incidence and prevalence in Indonesia

Wahyuningsih

Adawiyah

Sjam

et al. 2021

Mycoses

View full text Add to dashboard Cite

show abstract

“…6 Prevalensi MK pada penderita HIV tahun 2018 dilaporkan sebesar 7,1% di Bandung dan 7,32% di Surabaya. 7,8 Jamur Cryptococcus dapat ditemukan di alam dan bersifat saprofit. Cryptococcus neoformans CDK-292/ vol.…”

Section: Etiologiunclassified

Meningitis Kriptokokus pada Penderita HIV

Wijaya

2021

CDK

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<p>Meningitis kriptokokus (MK) merupakan salah satu bentuk infeksi oportunistik pada penderita HIV yang memiliki tingkat mortalitas tinggi. Infeksi jamur ini didapat dari inhalasi spora Cryptococcus yang ada di alam dan selanjutnya berkolonisasi di paru. Pada individu yang mengalami penurunan imunitas seluler seperti penderita HIV, jamur ini dapat berdiseminasi secara hematogen terutama ke sistem saraf pusat. Saat ini, diagnosis pasti kriptokokosis dapat mengandalkan hasil tes antigen Cryptococcus dari cairan serebrospinal dan darah. Prinsip pemberian antijamur pada pasien MK dengan HIV terdiri dari 3 fase, yakni: induksi, konsolidasi, dan pemeliharaan. Selain itu, perlu penundaan pemberian obat antiretroviral saat pemberian terapi antijamur MK.</p><p>Cryptococcal meningitis (CM) is an opportunistic infection in people with HIV, with a high mortality rate. This fungus infection is acquired from inhalation of Cryptococcus spores that exist in nature and then colonizes in the lungs. In individuals with decreased cellular immunity such as HIV, this fungus can cause hematogenous dissemination primarily to the central nervous system. Currently, definitive diagnosis of cryptococcosis can rely on the results of the Cryptococcus antigens test from cerebrospinal fluid and blood. The principle of antifungal administration in CM patients with HIV consists of 3 phases: induction, consolidation, and maintenance. It is also necessary to delay the administration of antiretroviral drugs while administering CM antifungal therapy.</p>

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CRYPTOCOCCAL ANTIGENEMIA IN HIV/AIDS PATIENTS USING LATERAL FLOW IMMUNOASSAY DETECTION AT Dr. SOETOMO GENERAL HOSPITAL SURABAYA

Cited by 2 publications

References 20 publications

Serious fungal disease incidence and prevalence in Indonesia

Serious fungal disease incidence and prevalence in Indonesia

Meningitis Kriptokokus pada Penderita HIV

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