Cryptococcal Osteomyelitis, Pulmonary Sarcoidosis, and Tuberculosis in a Single Patient

Mi, Shaff; Jl, Berger; Ne, Green

doi:10.1097/00007611-198202000-00026

Cited by 10 publications

(9 citation statements)

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“…Although, combination therapy with AMB and 5-FC (with or without surgery) did not outperform AMB alone (with or without surgery) in terms of improving the mortality rate (which might be due to the small number of cases), combined therapy is recommended. This result is contrary to previous reports (Bryan, 1977 ; Poliner et al, 1979 ; Shaff et al, 1982 ; Raftopoulos et al, 1998 ; Perfect et al, 2010 ) and might be due to the small number of cases reviewed here. Thus, combined therapy is recommended given the prevention of secondary drug resistance, the shorter duration of therapy, smaller total dosage, and the reduced likelihood of side effects (Bryan, 1977 ; Raftopoulos et al, 1998 ; Jain et al, 2011 ).…”

Section: Discussioncontrasting

confidence: 99%

Skeletal cryptococcosis from 1977 to 2013

Zhou

Chu

et al. 2015

Front. Microbiol.

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Skeletal cryptococcosis, an aspect of disseminated cryptococcal disease or isolated skeletal cryptococcal infection, is a rare but treatable disease. However, limited information is available regarding its clinical features, treatment, and prognosis. This systematic review examined all cases published between April 1977 and May 2013 with regard to the factors associated with this disease, including patient sex, age, and epidemiological history; affected sites; clinical symptoms; underlying diseases; laboratory tests; radiological manifestations; and delays in diagnosis, treatment, follow-up assessments, and outcomes. We found that immune abnormality is a risk factor but does not predict mortality; these observations are due to recent Cryptococcus neoformans var gattii (CNVG) outbreaks (Chaturvedi and Chaturvedi, 2011). Dissemination was irrespective of immune status and required combination therapy, and dissemination carried a worse prognosis. Therefore, a database of skeletal cryptococcosis cases should be created.

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Section: Discussioncontrasting

confidence: 99%

Skeletal cryptococcosis from 1977 to 2013

Zhou

Chu

et al. 2015

Front. Microbiol.

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“…The presence of both tuberculosis and cryptococcosis in the same patients is interesting and was reported in three patients [5,17,20] (Table 1). C. neoformans inhibits the production of tumor necrosis factor alpha (TNF-α), interleukin (IL)-12 and IL-18, and interferon gamma (IFN-γ) (Th1 responses) and stimulates production of IL-10 (a Th2 response) [46].…”

Section: Discussionmentioning

confidence: 78%

Cryptococcus neoformans Abscess and Osteomyelitis in an Immunocompetent Patient with Tuberculous Lymphadenitis

Al‐Tawfiq

Ghandour

2007

Infection

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Infection with Cryptococcus neoformans usually occurs in immunocompromised hosts and may occur in immunocompetent patients. Of all cryptococcal infections, 10-40% of patients have no apparent immune deficiency. Disseminated disease may occur in up to 62% of HIV-seronegative patients with cryptococcosis; however, cryptococcal osteomyelitis is rare. Here, we report an immunocompetent patient with cryptococcal vertebral osteomyelitis and concomitant tuberculous lymphadenitis. The patient received 12 weeks of fluconazole and a 1-year course of anti-tuberculous agents, with complete recovery.

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“…As illustrated in this case, the difficulty in arriving at an early diagnosis can result in the patient being treated for idiopathic sudden hearing loss with steroids which can potentially aggravate the unrecognized infection [4]. The harmful effects of steroids have been highlighted in a report of pulmonary tuberculosis and cryptococcal osteomyelitis induced by steroid therapy for sarcoidosis [8].…”

Section: Discussionmentioning

confidence: 99%

Cryptococcal Meningitis: Implications for the Otologist

Low¹

2002

ORL

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Cryptococcal meningitis can present to the otologist with hearing loss and vestibular dysfunction. A man with cryptococcal meningitis presenting with bilateral profound sensorineural hearing loss and vestibular dysfunction is described. The difficulty in arriving at the diagnosis and consequences of misdiagnosis are discussed. Histological and clinical studies suggest that the cochlear nerve is likely to be damaged in patients who have deafness associated with this disease. Retrocochlear damage may result in cochlear implantation having a poor outcome.

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Cryptococcal Osteomyelitis, Pulmonary Sarcoidosis, and Tuberculosis in a Single Patient

Cited by 10 publications

References 0 publications

Skeletal cryptococcosis from 1977 to 2013

Skeletal cryptococcosis from 1977 to 2013

Cryptococcus neoformans Abscess and Osteomyelitis in an Immunocompetent Patient with Tuberculous Lymphadenitis

Cryptococcal Meningitis: Implications for the Otologist

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