Cryptogenic organizing pneumonia

Cordier, J.-F.

doi:10.1016/j.ccm.2004.06.003

Cited by 76 publications

(47 citation statements)

References 114 publications

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“…The systemic inflammation caused by OP could have an effect in different organs, including the cardiovascular system. 3 Our findings on the causes of death in patients with COP and SOP, with respiratory disease being the most common, are in agreement with those of Lohr et al 7 We found a low rate of mortality from the disease itself, but patients died from other respiratory causes and their underlying disease. It was common for patients in our study to have underlying lung disease when diagnosed with OP.…”

Section: Discussionsupporting

confidence: 92%

Epidemiology of organising pneumonia in Iceland

Guðmundsson

Sveinsson

Ísaksson

et al. 2006

Thorax

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Background: Cryptogenic organising pneumonia (COP) has also been called idiopathic bronchiolitis obliterans organising pneumonia. In secondary organising pneumonia (SOP) the causes can be identified or it occurs in a characteristic clinical context. The aim of this study was to determine the incidence and epidemiological features of COP and SOP nationwide in Iceland over an extended period. Methods: A retrospective study of organising pneumonia (OP) in Iceland over 20 years was conducted and the epidemiology and survival were studied. All pathological reports of patients diagnosed with or suspected of having COP or SOP in the period 1984-2003 were identified and the pathology samples were re-evaluated using strict diagnostic criteria. Results: After re-evaluation, 104 patients fulfilled the diagnostic criteria for OP (58 COP and 46 SOP). The mean annual incidence of OP was 1.97/100 000 population (1.10/100 000 for COP and 0.87/ 100 000 for SOP). The mean age at diagnosis was 67 years with a wide age range. The most common causes of death were lung diseases other than OP, and only one patient died from OP. Patients with OP had a lower rate of survival than the general population, but there was no statistical difference between COP and SOP. Conclusions: The incidence of OP is higher than previously reported, suggesting that OP needs to be considered as a diagnosis more often than has been done in the past.

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Section: Discussionsupporting

confidence: 92%

Epidemiology of organising pneumonia in Iceland

Guðmundsson

Sveinsson

Ísaksson

et al. 2006

Thorax

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“…There may also be some other key features 12. Pathological findings compatible with COP are uniform recent visual changes without severe disruption of the lung architecture, a patchy and peribronchiolar distribution, lesions localised within the air spaces, foamy macrophages commonly seen in alveolar spaces, intraluminal buds of granulation tissue, severe fibrotic changes (which are unusual) and giant cells (which are rare), as well as no granulomas or vasculitis.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence and prevalence are unknown. It occurs in the fifth or sixth decade of life without gender preference and with no association with smoking habits 10 – 12. The majority of patients are symptomatic until a few weeks before diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Bilateral pulmonary nodules in an adult patient with bronchiolitis obliterans-organising pneumonia

Kopanakis¹,

Golias²,

Patentalakis³

et al. 2009

Case Reports

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A 58-year-old male ex-smoker was admitted to hospital because of nodular infiltrates on chest x rays. He was complaining of fatigue, dyspnoea with exertion, low grade fever and weight loss. Physical examination was unremarkable. Bronchoscopy was inconclusive but revealed endobronchial lesions of chronic active inflammation. The diagnosis of cryptogenic organising pneumonitis bronchiolitis obliterans-organising pneumonia (COP-BOOP) was established by open lung biopsy. Proliferative bronchiolitis with regions of organising pneumonia is the characteristic feature of COP. The radiological picture of bilateral pulmonary nodules is an infrequent manifestation of COP. Lung biopsy, open or with video assistance thoracic surgery, is recommended to confirm the diagnosis.

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“…In this context, airway fibrosis likely resembles fibrosis in other tissues, which, despite long held assumptions, may be reversible 24 25. In some settings, airways fibrosis does appear to resolve 26. In addition, the goblet cell metaplasia that is frequently present in patients with chronic bronchitis can reverse 27.…”

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confidence: 99%