Crystal structure mediates mode of cell death in TiO2 nanotoxicity

Braydich‐Stolle, Laura K.; Schaeublin, Nicole M.; Murdock, Richard C.; Jiang, Jingkun; Biswas, Pratim; Schlager, John J.; Hussain, Saber M.

doi:10.1007/s11051-008-9523-8

Cited by 210 publications

(169 citation statements)

References 21 publications

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“…Further, aggregations derived from rutile TiO 2 NPs show better suspensions stability and dispersibility than those from anatase TiO 2 NPs (see Table 2). The result was also noticed previously in deionized water as well as in PBS (Braydich-Stolle et al 2009;Bolis et al 2012). This finding confirms the fact that aggregations of TiO 2 NPs depend on crystal structures, which is relating to surface charges, atom arrangement and architectural feature of TiO 2 NPs.…”

Section: Discussionsupporting

confidence: 90%

“…4). Previous studies indicated that anatase TiO 2 NPs induced cell necrosis regardless of sizes (Braydich-Stolle et al 2009) and aggregation formed through van der Waals force could convert to single nanocrystal which had nano-effect ). This conversion had been confirmed by that 40 nm Effects of humic acid and ionic strength on TiO 2 nanoparticles sublethal toxicity to zebrafish 2063 nanoparticles were existing in both TiO 2 NPs and ZnO NPs aggregations (De Berardis et al 2010).…”

Section: Discussionmentioning

confidence: 99%

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Effects of humic acid and ionic strength on TiO2 nanoparticles sublethal toxicity to zebrafish

Fang

Zhang

et al. 2015

Ecotoxicology

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The stability and bioavailability of titanium dioxide nanoparticles (TiO 2 NPs) suspension could be modified by the physicochemical properties of solution. In the present study, the effect of humic acid (HA) and ionic strength (by adding NaCl) on aggregation and sedimentation of TiO 2 NPs suspension were investigated. Accordingly, the sublethal toxicity of TiO 2 NPs suspensions with different HA and NaCl concentrations toward zebrafish (Danio rerio) was evaluated by monitoring the changes of superoxide dismutase, catalase, malonaldehyde and glutathione in gill, liver and intestine. The results showed that the aggregations formation and hydrodynamic diameter of TiO 2 NPs in suspensions are not essential characteristics to decide toxicity. The varied oxidative stress responses detected in gill, liver and intestine derived from different toxicity mechanisms of TiO 2 NPs. Nevertheless, the oxidative stress could be suppressed by the adding of HA and/or the increase of ionic strength, which can decrease the bioavailability of TiO 2 NPs in water. The study suggests that the environmental factors, such as HA and ionic strength, are important for the fate (aggregation and sedimentation) and toxicity of nanomaterials in aquatic environment.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Effects of humic acid and ionic strength on TiO2 nanoparticles sublethal toxicity to zebrafish

Fang

Zhang

et al. 2015

Ecotoxicology

View full text Add to dashboard Cite

show abstract

“…The results showed that particle surface reactivity plays a more important role in toxicity than particle size or surface area [102]. In contrast, another study found that anatase TiO 2 did not induce greater ROS generation and that viability did not differ significantly in cells treated with anatase, rutile, and mixed crystal TNPs [93].…”

Section: Crystal Formmentioning

confidence: 92%

“…Rutile TNPs induced apoptosis through ROS generation [59], while anatase TNPs caused necrosis by inducing membrane leakage [93]. TNPs induced mitotic perturbation, DNA damage, formation of micronuclei (MN), and eventually, apoptosis in Syrian hamster embryo cells [94].…”

Section: Toxicity Of Tnps To Mammalian Cellsmentioning

confidence: 99%