2019
DOI: 10.1107/s2053229619004819
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Crystal structures and properties of two hydrated conglomerate forms of the heart-rate-lowering agent ivabradine hydrochloride

Abstract: Ivabradine hydrochloride (IVA-HCl) (systematic name: { [3,4-dimethoxybicyclo-[4.2.0]octa-1(6),2,4-trien-7-yl]methyl} [3-(7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)propyl]methylazanium), is a novel medication used for the symptomatic management of stable angina pectoris. In many recent patents, it has been claimed to exist in a very large number of polymorphic, hydrated and solvated phases, although no detailed analysis of the structural features of these forms has been published to date. Here… Show more

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Cited by 2 publications
(2 citation statements)
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“…Another example is the case of carbamazepine, whose hydration was inhibited by short chain substituted cellulose like HPMC (hydroxypropylmethyl cellulose) and MC. The same trend has been observed for PVA and PVP; that is, longer chains exhibited lower efficiency [ 155 ].…”
Section: Influence Of Excipients On Api Hydratessupporting
confidence: 74%
See 1 more Smart Citation
“…Another example is the case of carbamazepine, whose hydration was inhibited by short chain substituted cellulose like HPMC (hydroxypropylmethyl cellulose) and MC. The same trend has been observed for PVA and PVP; that is, longer chains exhibited lower efficiency [ 155 ].…”
Section: Influence Of Excipients On Api Hydratessupporting
confidence: 74%
“…Similar results deliver examination of griseofulvin-acesulfame hydrate. It presents remarkable thermal stability at different RH up to 13 weeks and has an improved dissolution rate when compared with the griseofulvin hydrate [ 155 ].…”
Section: Hydrates’ Stability Selected Cases Within the Last 10 Yementioning
confidence: 99%