Crystallization of silk fibroin from solution

Magoshi, Jun; Magoshi, Yoshiko; Becker, Mary Ann; Katô, Masao; Han, Zhang; Tanaka, Toshihisa; Inoue, Shoichi; Nakamura, Shuichi

doi:10.1016/s0040-6031(99)00462-1

Cited by 41 publications

(47 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8b). The insolubility property and the crystal structure finding are consistent with the literature [10,[37][38][39]. It was, thus, confirmed by both FTIR spectra and X-ray diffraction that the secondary structure of fibroin molecules changed to b-sheets.…”

Section: Coating With Edc Cross-linked Sfsupporting

confidence: 90%

“…This structure produces morphology with aggregated fibrils. The starting solution concentration and casting temperature are of critical importance for the structure of the fabricated films [39]. Insolubilization of fibroin coating around the tablet is required to achieve sustained release of theophylline.…”

Section: Coating With Heat-treated Sfmentioning

confidence: 99%

“…After coating the prepared theophylline tablets using SF solution the tablets were dried at 45 8C in a static oven in order to convert the structure from random coil to b-sheet form. The conformational change in SF structure was investigated earlier in the literature [37][38][39]. By achieving b-sheet transformation of the silk fibroin, insoluble membranes could be obtained.…”

Section: Coating With Heat-treated Sfmentioning

confidence: 99%

See 2 more Smart Citations

Silk fibroin as a novel coating material for controlled release of theophylline

Bayraktar

Malay

Özgarip

et al. 2005

European Journal of Pharmaceutics and Biopharmaceutics

113

View full text Add to dashboard Cite

The aim of this study was to explore potential use of the silk fibroin (SF) as an aqueous coating material for theophylline tablets. We have examined the film forming and coating properties of heat-treated fibroin, SF solution having different amounts of polyethylene glycol (PEG) and 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide (EDC) cross-linked SF. Heat-treated SF material possessed a brittle structure, which resulted in poor film forming and coating properties. The optimum PEG amount in SF solution was determined as 17% (by weight) for an acceptable film forming and zero order release profile. EDC cross-linked SF has shown a very good film forming and coating property with a potential for sustaining the drug release from coated theophylline tablets. Dissolution data for coated theophylline tablets were analyzed using Ritger and Peppas equation to describe the mechanism of drug release. Drug release from the EDC coated tablets followed zero-order kinetics. Release rate constants were found to be 0.26, 0.19, 0.16% min K1 for single-coated, double coated, and triple coated tablets, respectively. These results clearly demonstrated that silk fibroin has high utility as a novel aqueous coating material for controlled release products. q

show abstract

Section: Coating With Edc Cross-linked Sfsupporting

confidence: 90%

Section: Coating With Heat-treated Sfmentioning

confidence: 99%

Section: Coating With Heat-treated Sfmentioning

confidence: 99%

See 1 more Smart Citation

Silk fibroin as a novel coating material for controlled release of theophylline

Bayraktar

Malay

Özgarip

et al. 2005

European Journal of Pharmaceutics and Biopharmaceutics

113

View full text Add to dashboard Cite

show abstract

“…Algunos tratamientos térmicos o el uso de ciertos solventes (etanol, metanol, entre otros), pueden generar cambios en la conformación estructural de la proteína [36]. Estas variaciones a su vez, producen alteraciones en las propiedades químicas y físicas de la FS, la cuales son determinadas mediante pruebas de caracterización como pruebas reológicas para determinar la viscosidad [37], análisis térmicos para evaluar el comportamiento en función de la temperatura [38], determinación del peso molecular [39] y otros análisis.…”

Section: Generalidades De La Fsunclassified

“…Estas variaciones a su vez, producen alteraciones en las propiedades químicas y físicas de la FS, la cuales son determinadas mediante pruebas de caracterización como pruebas reológicas para determinar la viscosidad [37], análisis térmicos para evaluar el comportamiento en función de la temperatura [38], determinación del peso molecular [39] y otros análisis. De igual manera, el método de obtención de la FS, puede ser un factor que genere cambios en las estructuras de la proteína [36].…”

Section: Generalidades De La Fsunclassified

Revisión: Fibroína de seda y sus potenciales aplicaciones en empaques biodegradables para alimentos/Review: silk fibroin and their potential applications on biodegradable food packaging

et al. 2017

View full text Add to dashboard Cite

RESUMENEl cuidado del medioambiente y el uso responsable de los recursos, ha promovido investigaciones con diferentes biopolímeros que permitan el desarrollo de nuevos materiales que puedan ser empleados en empaques para alimentos. Entre estos biopolímeros se encuentra la fibroína de seda (FS), que representa cerca del 70% de la fibra de seda y puede ser obtenida a partir de capullos de primera calidad o de los desperdicios generados en la producción serícola. En el desarrollo de empaques de alimentos con FS, se pueden dar dos alternativas de producción, una en la que la FS puede ser funcionalizada por otros componentes, y otra en la que se incluye la FS como componente funcional modificando otros biopolímeros. La FS puede conferirle al material de empaque ciertas propiedades, como: aumento de la permeabilidad de oxígeno, resistencia a la rotura y una mayor velocidad de degradación del biopolímero. Este artículo se centra en cuatro temas principales: empaques, biopolímeros en empaques, FS y finalmente, la FS en empaques para alimentos.Palabras clave: Empaques, Materiales poliméricos, Biopolímeros, Fibroína de seda, Biomateriales. ABSTRACTEnvironmental protection and responsible use of resources, have promoted research of different biopolymers allowing to develop biodegradable materials which can be used in food packaging. Among these biopolymers is silk fibroin (SF), this protein represents nearly 70% of the silk fiber and it can be obtained from high quality cocoons or from waste generated in the silk industry. In the development of food packaging with SF, there are two possible alternative of production, one in what the SF can be functionalized by other components and another in which, the FS is included as functional component modifying other biopolymers. In the case of food packaging, the SF can concede desirable properties to the package such as an increase in oxygen permeability, more tensile strength and a higher biopolymer degradation rate. This paper is focused on four main topics: packaging, biopolymers in packaging, SF and finally, the SF in food packaging.

show abstract