CT and MR imaging findings in adults with cerebellar medulloblastoma: comparison with findings in children.

Bourgouin, Pierre; Tampieri, Donatella; Grahovac, Steven; Léger, Christophe; Carpio, R. del; Melançon, Denis

doi:10.2214/ajr.159.3.1503035

Cited by 81 publications

(68 citation statements)

References 9 publications

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“…We described this appearance as moon -surface , which represents not only round shape of the moon but also surface characteristics formed by lunar mountains, seas and craters. The prevalence of cystic and necrotic degeneration found in the study by Bourgouin et al (6) was high(82%) compared to 10 -20% in most studies. It was believed to be high because their series included only adults (age range , 18-47 years(mean , 28 years)) , and cystic and necrotic degeneration is presumably more common in this age group.…”

Section: Introductionmentioning

confidence: 62%

“…On the other hand , slightly more than half of their tumors showed only small or intermediate degrees of enhancement compared to a marked degree in the majority of our cases , although we used the same imaging method immediately after manual intravenous injection of contrast media. Desmoplastic medulloblastoma was reported to show less contrast enhancement because of a large amount of reticulin fibers in their stroma (6,8,9) Medulloblastomas are well known for metastasis through the CSF pathway. Nelson et al (7) found imaging evidence of metastatic disease in 5% of 223 tumors evaluated by CT. Only one of 25 patients in a series evaluated by Meyers et al(1) had intracranial metastatic disease at the time of MR imaging.…”

Section: Introductionmentioning

confidence: 99%

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MRI Findings of Vermian Medulloblastoma

Jung

Choi

Chung

et al. 1996

J Korean Radiol Soc

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Purpose: To find characteristic MRI features ofvermian medulloblastoma. Materials and Methods: MRI studies and medical records were retrospectively reviewed for 12 patients with surgically proven midline medulloblastoma. The assessment concerned appearance ofthe mass in relation to surrounding structures ; MR signal intensity; the enhancement pattern; the mass' s location and size; presence of a cystic/necrotic area, calcification , or vascular void; extension through the foramen Luschka; degree of hydrocephalus; and presence of tonsillar herniation.Results: The midline medulloblastoma commonly showed roundish moon -surface appearance, especially on the axial T2-weighted images. AII tumors showed heterogeneous signal intensities mainly due to intratumoral cystic/necrotic or hemorrhagic changes. The tumors were commonly located at mid-and/or inferior vermis. Occasionally the tumors extended through the foramen Luschka, and caused obstructive hydrocephalus of moderate to severe degree. Post-contrast study showed heterogeneous, dense contrast enhancement in the majority of patients.Conclusion : The MR finding of the moon-surface appearance formed by both the mass and the intratumoral cystic/necrotic change as seen on axial T2-weighted images could be hel pf 비 in the diagnosis of vermian medu lI oblastoma.

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Section: Introductionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

MRI Findings of Vermian Medulloblastoma

Jung

Choi

Chung

et al. 1996

J Korean Radiol Soc

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“…El hallazgo clásico es una masa hiperdensa en un estudio simple, que se capta marcadamente después de la inyección del medio de contraste 29 .…”

Section: Imaginologíaunclassified

“…tología del líquido cefalorraquídeo antes o después de cirugía predice una tasa incrementada de recaída y pobre desenlace; aunque una citología negativa no excluye una enfermedad más avanzada de la enfermedad. Idealmente debe esperarse la punción lumbar hasta después de la cirugía debido a la presencia de hipertensión endocraneana o hidrocefalia obstructiva [28][29][30] .…”

Section: Tratamientounclassified

Meduloblastoma: de la clasificación histológica a la molecular

Pabón

Hoyos

Restrepo

et al. 2018

MedUPB

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RESUMENEl meduloblastoma es un tumor frecuente en la población pediátrica, pero es raro en pacientes adultos. Es la segunda causa de muerte por cáncer en menores de 15 años. El hallazgo de una lesión tumoral cerebelosa mediana o paramediana que capta el medio de contraste y que a menudo comprime el cuarto ventrículo sugiere la presencia de este tumor. A través del uso de estudios de expresión génica y marcadores moleculares se ha generado una nueva aproximación a la clasificación del meduloblastoma. Así, se ha venido a entender el concepto de meduloblastoma no como una patología sino como un grupo de patologías distintas clínica y molecularmente. La resonancia magnética nuclear espinal y la punción lumbar deben ser realizadas en todos los pacientes como parte de la evaluación de la extensión de la enfermedad, debido a que las leptomeninges espinales son un sitio frecuente de diseminación. El tratamiento implica idealmente la interacción de un grupo interdisciplinario que pueda ofrecer al paciente: cirugía, radioterapia y quimioterapia. El pronóstico depende de variables como edad (menor de tres años), diseminación de la enfermedad, residuo tumoral posquirúrgico, variante histológica de células grandes/anaplásico, y pertenecer al grupo 3 (grupo de amplificacón del MYC).Palabras clave: cerebelo; meduloblastoma; expresión génica; clasificación. ABSTRACTMedulloblastoma is a common tumor in children, but is rare in adults. It is the second most common cause of cancer-related death in patients under 15 years. The presence of a median or paramedian enhancing cerebellar mass, often compressing the fourth ventricle may indicate the presence of this tumor. Genetic and molecular markers offer a new approach to the understanding and classification of medulloblastomas. Hence, we have come to understand medulloblastoma not as a sole disease but rather, as a group of clinically and molecularly distinct pathologies. Magnetic resonance imaging of the spine and lumbar puncture must be performed in all patients as part of the assessment of the extent of disease, since spinal leptomeninges are common sites for metastatic dissemination. Ideally, its treatmeant involves an interdisciplinary group that provides surgery, radiotherapy, and chemotherapy. Prognosis depends upon variables such as age (under three years), metastatic dissemination, residual tumor after surgery, large cell/ anaplastic histological variant, and group 3 tumor (MYC amplification group).

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“…The peak of occurrence is between 5-7 years of age, with 70% of them occurring under 16 years. At the presentation, truncal ataxia, intracranial hypertension syndrome, lethargy, headache, and morning vomiting are the most frequent symptoms [1][2][3] . On CT scans, these tumors are described as a welldefined, hyperdense and homogeneous midline mass with marked enhancement after contrast injection.…”

mentioning

confidence: 99%

Adult cerebellar medulloblastoma: CT and MRI findings in eight cases

Neto

Gasparetto²,

Ono³

et al. 2003

Arq. Neuro-Psiquiatr.

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-Medulloblastoma is a brain tumor of neuroepithelial origin, which represents 15 to 30% of all pediatric brain tumors, and less than 1% of CNS adult neoplasms. We report the imaging findings of 8 adult patients with medulloblastoma. The mean age was 35 years, ranging from 20 to 65 years, and the male:female rate was 3:5. The tumors were predominantly lateral (63%), hyperdense on CT scans (83%), and on the MRI, hypointense on T1 (100%) and hyperintense on T2 (80%) weighted images. It was seen intratumoral necrosis and cysts in six cases and calcifications in three. Hydrocephalus was observed in 5 cases and brain stem invasion in four. The imaging findings of medulloblastomas in adults are different of those in child, and also nonspecific. Although these tumors are uncommon in adults, they must be considered in the differential diagnosis of cerebellar masses in the posterior fossa of this age group.KEY WORDS: medulloblastoma, adults, computed tomography, magnetic resonance imaging.Meduloblastoma cerebelar em adultos: achados de TC e RM em oito casos Meduloblastoma cerebelar em adultos: achados de TC e RM em oito casos Meduloblastoma cerebelar em adultos: achados de TC e RM em oito casos Meduloblastoma cerebelar em adultos: achados de TC e RM em oito casos Meduloblastoma cerebelar em adultos: achados de TC e RM em oito casos RESUMO -O meduloblastoma é um tumor de origem neuroepitelial, que representa entre 15 e 30% dos tumores cerebrais em crianças e menos de 1% das neoplasias intracranianas em adultos. Apresentamos os achados de imagem de 8 pacientes adultos com meduloblastoma. A média de idade foi 35 anos, variando entre 20 e 65 anos, e a relação homem:mulher foi 3:5. Os tumores foram predominantemente laterais (63%), hiperdensos na tomografia computadorizada (83%), e, na ressonância magnética, hipointensos nas imagens ponderadas em T1 (100%) e hiperintensos nas ponderadas em T2 (80%). Necrose e cistos intratumorais foram observados em seis casos e calcificações em três. Cinco pacientes apresentavam hidrocefalia e quatro tinham invasão neoplásica do tronco cerebral. Os achados de imagem dos meduloblastomas em adultos são inespecíficos e diferentes daqueles que acometem crianças. Apesar destes tumores serem incomuns em adultos, eles devem sem considerados no diagnóstico diferencial de massas cerebelares na fossa posterior de pacientes neste grupo etário.

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CT and MR imaging findings in adults with cerebellar medulloblastoma: comparison with findings in children.

Abstract: The CT findings of medulloblastoma in adults usually differ from those of medulloblastoma in children. The tumor has a variable and nonspecific appearance in adults and should always be considered in the differential diagnosis of a mass in the posterior fossa.

Cited by 81 publications

References 9 publications

MRI Findings of Vermian Medulloblastoma

MRI Findings of Vermian Medulloblastoma

Meduloblastoma: de la clasificación histológica a la molecular

Adult cerebellar medulloblastoma: CT and MRI findings in eight cases

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