CT vs 68Ge attenuation correction in a combined PET/CT system: evaluation of the effect of lowering the CT tube current

Kamel, Emad Zarief; Hany, Thomas F.; Burger, Cyrill; Treyer, Valérie; Lonn, A. H. R.; Schulthess, Gustav K. von; Buck, Alfred

doi:10.1007/s00259-001-0698-9

Cited by 131 publications

(74 citation statements)

References 4 publications

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“…It has previously been shown that this reduction in mA gives CT scans which are adequate for attenuation correction [10]. Each patient was asked to hold his/her breath at normal end-inspiration for about 10 to 15 seconds (depending on their height) for the first low dose CT scan, then at normal end-expiration for the second CT scan and finally at roughly mid-volume between end-expiration and end-inspiration for the third scan.…”

Section: Data Acquisitionmentioning

confidence: 99%

PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake

Meunier

Maass‐Moreno

Carrasquillo

et al. 2006

Journal of Nuclear Cardiology

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Section: Data Acquisitionmentioning

confidence: 99%

PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake

Meunier

Maass‐Moreno

Carrasquillo

et al. 2006

Journal of Nuclear Cardiology

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“…Taking into consideration the CT system used in the present study and the specific imaging technique of integrated PET/CT, the CT images evaluated have a lower image quality than could be expected if a standalone spiral CT or multislice CT were to be used. The CT part of the integrated PET/CT was performed with a lower dose (80 versus 120 mA for a dedicated chest CT in the Dept of Radiology, University Hospitals Gasthuisberg, Leuven, Belgium) [23]; however, HANY et al [24] compared different CT doses and found no significant differences in accuracy when 80 mA was used compared with that of a dedicated chest CT. The CT was performed at normal expiratory breath-hold (limited breath-hold technique) versus at deep inspiration for a dedicated chest CT.…”

Section: Value Of Integrated Pet/ct W De Wever Et Almentioning

confidence: 99%

Detection of extrapulmonary lesions with integrated PET/CT in the staging of lung cancer

Wever¹,

Vankan²,

Stroobants³

et al. 2007

Eur Respir J

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The aim of the present study was to assess retrospectively the additional value of positron emission tomography (PET)/computed tomography (CT) in the detection of unexpected extrapulmonary lesions in the staging of patients with a malignant pulmonary lesion in comparison with CT and PET used alone.A total of 217 patients with a pathologically proven lung tumour underwent PET/CT. CT, PET and PET/CT were evaluated in the detection of extrapulmonary lesions. These abnormalities were compared with the final diagnosis obtained from the medical records and statistical analysis was carried out.In total, 108 lesions were clinically detected. PET/CT showed a sensitivity, specificity, positive and negative predictive values and accuracy of 100, 81, 71, 100 and 87%, respectively, for the detection of extrapulmonary lesions and 92, 98, 89, 98 and 97%, respectively, for the detection of malignant extrapulmonary lesions. PET/CT was significantly better than CT and PET used alone.Conventional staging work-up has a poor sensitivity in detecting second primary cancers or unexpected metastases. The detection of malignant extrapulmonary lesions is necessary for correct tumour staging. By combining both metabolic and anatomical information, positron emission tomography/computed tomography is able to depict more unexpected extrapulmonary lesions than computed tomography and positron emission tomography used alone, and positron emission tomography/computed tomography provides more additional information of malignancy or benignancy of lesions detected with one of the two imaging modalities alone.KEYWORDS: Extrapulmonary lesion, integrated positron emission tomography/computed tomography, lung cancer L ung cancer is a common disease and is the leading cause of death in many countries. Several imaging techniques are available to detect distant metastases of lung cancer. Computed tomography (CT) is the routine imaging procedure for staging patients with lung cancer in many institutions. Usually, a combination of a CT scan of the brain to exclude brain metastasis, a CT scan of the upper abdomen to exclude liver and adrenal metastasis, and bone scintigraphy to exclude bone metastases are performed [1]. However, the technique of CT is often not able to exclude reliably extrapulmonary metastases, especially occult metastases, and to detect second primary cancers. Many reports suggest that F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is more sensitive than CT in the diagnosis of extrapulmonary lesions [2]. FDG-PET can detect unsuspected occult metastases and second primary cancers.In the study by STROOBANTS et al. [3], an additional detection of distant malignant lesions was found in 5% of patients. According to STROOBANTS et al. [3], the most important contribution of FDG-PET was its ability to exclude malignancy in the most distant lesions using equivocal CT.Recently, integrated PET/CT has been introduced more routinely into clinical situations [4]. Integrated PET/CT enables the direct correlation of FDG-accumula...

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“…Kamel et al [13] reported that the CT tube current can be reduced while still yielding adequate attenuation correction of PET scans, and CT tube currents in the range 10-120mA yielded the same values for FDG uptake or lesion size. Therefore, they showed that the very low CT tube current is sufficient if the CT scan is only used for attenuation correction.…”

Section: Discussionmentioning

confidence: 99%

“…However, the linear attenuation coefficients in the range 10-40mA yielded significant differences in the 500-mm obese patient simulated phantom. These finding indicated that an error in line attenuation coefficients in CT-based attenuation correction were most likely to have been caused by the much larger phantom size and a variety of CT scan-specific parameters [13,14], such as tube voltage (kVp), tube current (mA) and rotation time (s).…”

Section: Discussionmentioning

confidence: 99%

CT tube current for attenuation map in a combined PET/CT system: obese patient simulated phantom study

2012

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Objective The CT portion of PET/CT provides attenuation correction of the PET emission scan. This study was performed to evaluate how much CT tube current can be lowered while still providing attenuation maps on PET images.Methods Two body phantoms (outside diameters of 300 and 500 mm) were used to investigate and PET/CT acquisitions were performed with an Aquiduo PCA-7000B (Toshiba Medical Systems, Otawara, Japan). The CT scan was performed with the following parameters (120 kVp; 0.5-s rotation; 10, 20, 40, 80, 160, 200, 320, 460 mA).After the CT scan, PET images for 18 F-FDG (5.3 kBq/mL) were obtained for 4 min/bed position. The linear attenuation coefficients for 18 F-FDG in 300-and 500-mm phantoms, the pixel values and SD of CT images, the radioactivity concentration values and the hot-and cold-sphere contrast on PET images in the 500-mm phantom were evaluated. Results ConclusionsAlthough the linear attenuation coefficients in the 300-mm phantom remained the same with varying CT tube current, the 500-mm phantom yielded significant difference in the range 10-40mA. Therefore, the CT tube currents for attenuation correction should be adjusted over 40mA in obese patients.

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CT vs 68Ge attenuation correction in a combined PET/CT system: evaluation of the effect of lowering the CT tube current

Cited by 131 publications

References 4 publications

PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake

PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake

Detection of extrapulmonary lesions with integrated PET/CT in the staging of lung cancer

CT tube current for attenuation map in a combined PET/CT system: obese patient simulated phantom study

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