CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer

Solerio, E.; Tappero, G.; Iannace, L.; Matullo, Giuseppe; Ayoubi, M.; Parziale, Antonio; Cicilano, M.; Sansoè, G.; Framarin, L.; Víneis, Paolo; Rosina, F.

doi:10.1016/j.dld.2004.10.009

Cited by 24 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, CTLA-4 +49 G/A polymorphism is known to be associated with the risk of colorectal cancer in Chinese but no such association was seen in a study on Turkish patients (Dilmec et al, 2008;Qi et al, 2010). This SNP was also found to be not associated with colorectal neoplasm among Italian Caucasians (Solerio et al, 2005). According to a recent meta-analysis report CTLA4 +49A/G polymorphism is associated with an increased risk of Hashimoto's thyroiditis in Asian but not Caucasian populations (Feng et al, 2013).…”

Section: 2035 Lack Of Any Association Of the Ctla-4 +49 G/a Polymorpmentioning

confidence: 98%

Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population

Minhas¹,

Bhalla²,

Shokeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an important protein involved in the regulation of the immune system. The +49 G/A polymorphism is the only genetic variation in the CTLA-4 gene that causes an amino acid change in the resulting protein. It is therefore the most extensively studied polymorphism among all CTLA-4 genetic variants and contributions to increasing the likelihood of developing cancer are well known in various populations, especially Asians. However, there have hiterto been no data with respect to the effect of this polymorphism on breast cancer susceptibility in our North Indian population. We therefore assayed genomic DNA of 250 breast cancer subjects and an equal number of age-, sex-and ethnicity-matched healthy controls for the CTLA-4 +49 G/A polymorphism but no significant differences in either the gene or allele frequency were found. Thus the CTLA-4 +49 G/A polymorphism may be associated with breast cancer in other Asians, but it appears to have no such effect in North Indians. The study also highlights the importance of conducting genetic association studies in different ethnic populations.

show abstract

Section: 2035 Lack Of Any Association Of the Ctla-4 +49 G/a Polymorpmentioning

confidence: 98%

Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population

Minhas¹,

Bhalla²,

Shokeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…It is known that these polymorphic sites are within a region where regulatory elements could bind: for CD28 there is a splice receptor site and for ICOS an Sp1 binding site. Moreover, all the investigated polymorphisms are associated with susceptibility to malignancies [27][28][29][30][31][32][33][34][35][36][37][38][39][40] and autoimmune disease [24,41,42].…”

Section: Introductionmentioning

confidence: 99%

Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population

et al. 2010

View full text Add to dashboard Cite

“…It was reported that functional gene polymorphism is related to cancer susceptibility, outcome and drug sensitivity [16]. Several studies indicated that the CTLA-4 +49A>G polymorphisms were associated with the development of various cancers, such as colorectal cancer, breast cancer, gastric cancer, lymphoma, lung cancer and other cancers [17,18,19,20,21,22,23,24,25,26,27,28,29]; however, no studies have investigated the association between CTLA-4 +49A>G variant and cancer prognosis. Therefore we designed this study to evaluate the association between CTLA-4 +49A>G SNP and the prognosis of advanced NSCLC in a Chinese population.…”

Section: Introductionmentioning

confidence: 99%

CTLA-4 +49A>G Polymorphism Is Associated with Advanced Non-Small Cell Lung Cancer Prognosis

Song¹,

Liu

et al. 2011

Respiration

View full text Add to dashboard Cite

Background: Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by downregulating T cell activation. The most studied +49A>G polymorphism of the CTLA-4 gene has been associated with several autoimmune diseases. However, little is known about the association between this functional polymorphism of CTLA-4 and cancer prognosis. Objective: To investigate the association between CTLA-4 +49A>G polymorphism and prognosis of advanced non-small cell lung cancer (NSCLC) patients in a Chinese population. Methods: The CTLA-4 +49A>G polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 338 advanced NSCLC patients. Results: The frequencies of CTLA-4 +49 GG, GA and AA in advanced NSCLC patients were 44.4%, 42.0% and 13.6%, respectively. No significant association was observed between CTLA-4 +49A>G polymorphism and clinicopathologic features of advanced NSCLC including gender, histopathological type, clinical stage and tumor markers. Patients with the AA genotype had a survival time of 9.8 months, significantly shorter than those with the GG genotype (12.5 months) or the GA genotype (12.0 months) (p < 0.001; log-rank test). Multivariate Cox analysis further revealed that the CTLA-4 +49AA genotype is an independent adverse prognostic indicator for NSCLC patients. Conclusion: Our data suggest that the polymorphism of CTLA-4 +49A>G is a prognostic predictor for advanced NSCLC.

show abstract

CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer

Cited by 24 publications

References 15 publications

Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population

Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population

Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population

CTLA-4 +49A>G Polymorphism Is Associated with Advanced Non-Small Cell Lung Cancer Prognosis

Contact Info

Product

Resources

About