The prevalence of autoimmune diseases in patients with a late coeliac disease diagnosis does not correlate with duration of gluten intake. Early exposure to gluten may modify the immunological response. Gluten withdrawal does not protect patients with a late diagnosis from autoimmune diseases.

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Ulcerative colitis is a severe chronic and invalidating autoimmune disease of the gastrointestinal tract. Conventional medical treatment is based on intestinal local and systemic anti-inflammatory drugs, local and systemic steroids, and systemic immunosuppressant agents with multiple side effects. A case of steroid-dependent immunosuppressant-treated patient is illustrated. Homeopathic treatment rapidly improved the clinical picture and allowed withdrawal of immunosuppressants, but did not prevent long-term relapsing intestinal and extraintestinal inflammation. Subsequent administration of the homeopathic nosode Entamoeba histolytica healed the patient, with long-term normalisation of intestinal immune function.