Osteoporosis: still a typical complication of primary biliary cirrhosis?

Solerio, E.; Isaia, Giovanni Carlo; Innarella, R.; Stefano, Marco Di; Farina, Mariagiorgia; Borghesio, E.; Framarin, L.; Rizzetto, M.; Rosina, F.

doi:10.1016/s1590-8658(03)00078-1

Cited by 30 publications

(14 citation statements)

References 26 publications

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“…However, the relative increase of any fracture, hip fracture and ulna/radius fracture was as high as two‐fold for the PBC cohort . This observation is compelling, because of the suggestion of osteoporosis not being a complication of PBC, but just an expected disorder among postmenopausal middle‐aged women . Osteoporosis occurs frequently among patients with primary sclerosing cholangitis.…”

Section: Prevalence Of Osteoporosis and Fracturesmentioning

confidence: 93%

Osteoporosis in chronic liver disease

Guañabens

Parés

2018

Liver International

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Osteoporosis is a frequent complication in patients with chronic liver disease, especially in end-stages and in chronic cholestasis, in addition to non-alcoholic fatty liver disease, haemochromatosis and alcoholism. Mechanisms underlying osteoporosis are poorly understood, but osteoporosis mainly results from low bone formation. In this setting, sclerostin, a key regulator of the Wnt/β-catenin signalling pathway which regulates bone formation, in addition to the effects of the retained substances of cholestasis such as bilirubin and bile acids on osteoblastic cells, may influence the decreased bone formation in chronic cholestasis. Similarly, the damaging effects of iron and alcohol on osteoblastic cells may partially explain bone disease in haemochromatosis and alcoholism. A role for proinflammatory cytokines has been proposed in different conditions. Increased bone resorption may occur in cholestatic women with advanced disease. Low vitamin D, poor nutrition and hypogonadism, may be contributing factors to the full picture of bone disorders in chronic liver disease.

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Section: Prevalence Of Osteoporosis and Fracturesmentioning

confidence: 93%

Osteoporosis in chronic liver disease

Guañabens

Parés

2018

Liver International

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“…In addition, patients with PBC often have low physical activity and are more likely to fall [9], and also generally have lower levels of vitamin D than healthy people [16, 17]. Some studies indicate that in contrast to the general population, women with PBC are less predisposed to osteoporosis by menopause than by increased cholestasis and the severity of histological changes in the liver [10].…”

Section: Osteoporosis In Primary Biliary Cirrhosismentioning

confidence: 99%

Osteoporosis in primary biliary cirrhosis of the liver

Raszeja‐Wyszomirska¹,

Miazgowski²

2014

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Osteoporosis is a metabolic bone disease associated with a reduction in bone mass and deterioration of bone architecture, leading to increased fragility and subsequent low-trauma fractures in the vertebral column, hip, forearm and other bones. In literature, metabolic bone diseases such as osteoporosis and osteomalacia have been recognised as a complication of chronic liver disease, although the mechanisms of this association remain unclear. An increasing body of research data indicates a strong relationship between osteoporosis and primary biliary cirrhosis (PBC), which mainly results from early diagnosis of the disease, usually when it is still asymptomatic. The incidence of osteoporosis in PBC ranges from 20% to 44% and increases with the progression of the disease. Similarly, the incidence of bone fractures is high in this group of patients (10–20%). In this article, current knowledge on risk factors, pathogenesis, diagnosis and treatment of osteoporosis in PBC is reviewed.

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“…Its prevalence ranges from 0 to 67%, depending on the diagnostic procedure and the patients' characteristics [1,2]. Overall, the reported mean prevalence of this bone complication in most series is around 35% [3][4][5]. Concerns about the association of PBC with an increased risk of osteoporosis, however, have not only arisen in the last few years, but had already come up in the eighties when, in a small study, Cuthbert et al suggested an increased bone turnover in absence of osteoporosis [6].…”

Section: Introductionmentioning

confidence: 99%