Cu₂MoS₄ Nanozyme with NIR‐II Light Enhanced Catalytic Activity for Efficient Eradication of Multidrug‐Resistant Bacteria

Abstract

instead of CMS NPs dispersion for the saline and saline + NIR-II groups. 10 min later, infected site of the mice was irradiated by 1064 nm laser (1 W cm −2) for 5 min for saline + NIR-II and CMS + NIR-II groups. The infected area was monitored and photographed daily. At the therapeutic day 16, the infected tissues were homogenized and diluted in saline by ultrasonication. Then, these dilutions (100 µL) were plated on LB agar plates. The number of CFU was counted after incubation for 18 h at 37 °C. At the therapeutic day 16, the infected tissues were harvested, fixed in paraformaldehyde solution (4%), paraffined, sectioned, and observed after H&E staining by an Olympus IX-71 microscope.

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

“…[ 9 , 10 ] Compared with antibiotics, the ROS-based sterilization method can avoid the occurrence of bacterial resistance, therefore, the development of ROS-based antibacterial strategies is very effective and promising [ 11 ]. At present, it has been proved that many nanomaterials with enzyme-like and antibacterial properties, including noble metal nanoparticles [ 12 ], carbon-based nanomaterials [ 13 ], metal oxides [ 11 , 14 ], and metal chalcogenides [ [15] , [16] , [17] ], can eradicate different types of bacteria, even drug-resistant bacteria. Unfortunately, the low catalytic activity of nanozymes greatly limits their antibacterial effects [ 18 ].…”

“…Based on the Arrhenius equation, the rate of chemical reactions is positively related to temperature [ 22 ]. Starting from the basic principle that raising temperature can accelerate the rate of chemical reactions, increasing temperature of the bacterial infection sites to enhance the catalytic rate of nanozymes is an effective strategy [ 16 ]. Therefore, high temperature can significantly promote the production of ROS, thereby effectively killing bacteria.…”

“…Therefore, the combination of catalytic therapy and PTT can simultaneously enhance the catalytic production of ROS while reducing the collateral damage of PTT [ 15 , 27 ]. Although several nanozymes have been reported for PTT-catalytic antibacterial treatment, the treatment performance of these nanozymes is still limited [ 12 , [14] , [15] , [16] , 18 ]. Among the numerous nanozymes, copper-based nanomaterials not only have strong photothermal performance, but also undergo Fenton-like reactions in a wide pH range, thus exhibiting effects similar to iron-based catalysts [ 28 ].…”

The age of bioinspired molybdenum‐involved nanozymes: Synthesis, catalytic mechanisms, and biomedical applications

“…Very recently, Wang et al reported a new near-infrared II light-responsive Cu 2 MoS 4 nanozyme with enhanced OXDand POD-like catalytic activities to improve ROS generation for highly efficient killing of bacteria. 138 Although the abovementioned Mo-based nanozymes have been successfully employed to combating bacteria, more effort is required to focus on designing novel Mo-based nanozymes for combating more types of drug-resistance bacteria, promoting long-term wound healing, antibiofilm, and antibiofouling.…”

Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria

“…Recently, generating reactive oxygen species (ROS) via chemodynamic, photodynamic, sonodynamic, and enzyme-mimetic materials to combat bacteria has also been explored as promising alternative antibacterial strategies 9 – 11 . Among diverse ROS generation materials, the enzyme-mimetic catalysts, including nanoliposome 12 , metal-organic frameworks 13 – 15 , and inorganic materials 16 , 17 , have gained tremendous popularity by catalyzing oxygen and hydrogen peroxide (H 2 O 2 ) to generate ROS via the existing natural pathway. Nevertheless, when treated at a very low concentration, such enzyme-mimetic catalysts present insufficient bacterial killing activities, while utilizing antibacterial materials at high concentrations will always lead to a severe concern on biocompatibility.…”