Cuboidal W<sub>3</sub>S<sub>4</sub> Cluster Complexes as New Generation X-ray Contrast Agents

Yu, Shi-Bao; Droege, Michael; Segal, Brent M.; Kim, Sook-Hui; Sanderson, Tony; Watson, Alan D.

doi:10.1021/ic990976g

Cited by 23 publications

(22 citation statements)

References 20 publications

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“…These iodine contrast agents have a short blood half‐life, but are excellent for a number of clinical applications such as vascular imaging, owing to the fast scanning speed of CT . Nevertheless, a wide range of elements give good CT contrast and a number of types of formulations have been proposed as alternative CT contrast agents over the years such as gadolinium chelates or tungsten clusters . Nanoparticle contrast agents for CT were developed as early as the 1980s , but such reports were infrequent and the area did not grow .…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle contrast agents for computed tomography: a focus on micelles

Cormode

Naha

Fayad

2014

Contrast Media & Molecular

306

234

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Computed tomography (CT) is an X-ray based whole body imaging technique that is widely used in medicine. Clinically approved contrast agents for CT are iodinated small molecules or barium suspensions. Over the past seven years there has been a great increase in the development of nanoparticles as CT contrast agents. Nanoparticles have several advantages over small molecule CT contrast agents, such as long blood-pool residence times, and the potential for cell tracking and targeted imaging applications. Furthermore, there is a need for novel CT contrast agents, due to the growing population of renally impaired patients and patients hypersensitive to iodinated contrast. Micelles and lipoproteins, a micelle-related class of nanoparticle, have notably been adapted as CT contrast agents. In this review we discuss the principles of CT image formation and the generation of CT contrast. We discuss the progress in developing non-targeted, targeted and cell tracking nanoparticle CT contrast agents. We feature agents based on micelles and used in conjunction with spectral CT. The large contrast agent doses needed will necessitate careful toxicology studies prior to clinical translation. However, the field has seen tremendous advances in the past decade and we expect many more advances to come in the next decade.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle contrast agents for computed tomography: a focus on micelles

Cormode

Naha

Fayad

2014

Contrast Media & Molecular

306

234

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“…Transition metal chalcogenide cluster compounds with a heterocubane core represent a unique area of cluster chemistry. The interest in this class of compounds stems from their use as potential models for different catalytic processes with industrial and biological applications1–4 as well as their use as optical limiters and X‐ray contrast agents 5–8…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Structures and Magnetic Properties of New Chalcogen‐Bridged Heterodimetallic Cluster Compounds with Heterocubane Structure

Bechlars

Issac

Feuerhake³

et al. 2008

Eur J Inorg Chem

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The reaction of nickel, iron and cobalt complexes with MCl5 (M = Nb, Ta) and silylated chalcogen compounds in the presence of phosphane ligands yield the cluster compounds [Nb2Ni2S4Cl4(PPh3)2(CH3CN)2] (1), [Nb2Ni2Se4Cl4(PPh3)2(CH3CN)2] (2), [Ta2Ni2S4Br4(PPh3)2(CH3CN)2] (3), [Ta2Ni2Se4Br4(PPh3)2(CH3CN)2] (4), [Ni3S2(PMe3)6][Ta3NiS4(PMe3)4Cl6]2 (5), [Fe(dppm)2(CH3CN)2][NbFe3S4Cl3(dppm)(CH3CN)]2 (6) [dppm = (diphenylphosphanyl)methane], [Fe(dppm)2(CH3CN)2][TaFe3S4Cl3(dppm)(CH3CN)]2 (7), [FeCl(dppmSe)2][TaFe3Se4Cl3(dppm)(CH3CN)] (8) and [NbCo3Se4(PPh3)3(CH3CN)3][CoCl3(PPh3)] (9). The compounds (Et4N)3[NbFe2S4(SPh)4] (10) and (Et4N)3[NbFe2Se4(SPh)4] (11) were obtained by treating (Et4N)2[Fe(SPh)4] with Li3NbE4 (E = S, Se). (Et4N)3[Nb2Fe6S8(SPh)9] (12) was synthesized by adding FeCl2 to compound 10 used as starting material. (Et4N)3[Nb2Fe6Se8(SePh)9] (13) (which is isostructural to 12) was synthesized by treating FeCl2 with NaSetBu, NbCl5 and PhSeSiMe3. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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“…To overcome these limitations, a range of elements and a variety of formulations have been proposed as potential alternative X‐ray contrast agents. Earlier reports to develop new X‐ray diagnostic agents focused on systems such as tungsten clusters or gadolinium chelates (Schmitz, Wagner, Schuhmann‐Giampieri, Krause, & Wolf, 1997; S. Yu et al, 2000). The number of metal chelates and metalloclusters formed from different electron‐dense elements, such as hafnium and tantalum, has greatly expanded since then, and their physical characteristics, biocompatibility, and contrast properties have been studied (Berger et al, 2017).…”

Section: X‐ray Contrast Agentsmentioning

confidence: 99%

Nanoparticle contrast agents for X‐ray imaging applications

Hsu

Nieves

Betzer

et al. 2020

WIREs Nanomed Nanobiotechnol

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X-ray imaging is the most widely used diagnostic imaging method in modern medicine and several advanced forms of this technology have recently emerged. Iodinated molecules and barium sulfate suspensions are clinically approved X-ray contrast agents and are widely used. However, these existing contrast agents provide limited information, are suboptimal for new X-ray imaging techniques and are developing safety concerns. Thus, over the past 15 years, there has been a rapid growth in the development of nanoparticles as X-ray contrast agents. Nanoparticles have several desirable features such as high contrast payloads, the potential for long circulation times, and tunable physicochemical properties. Nanoparticles have also been used in a range of biomedical applications such as disease treatment, targeted imaging, and cell tracking. In this review, we discuss the principles behind X-ray contrast generation and introduce new types of X-ray imaging modalities, as well as potential elements and chemical compositions that are suitable for novel contrast agent development. We focus on the progress in nanoparticle X-ray contrast agents developed to be renally clearable, long circulating, theranostic, targeted, or for cell tracking. We feature agents that are used in conjunction with the newly developed multi-energy computed tomography and mammographic imaging technologies. Finally, we offer perspectives on current limitations and emerging research topics as well as expectations for the future development of the field.

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Cuboidal W₃S₄ Cluster Complexes as New Generation X-ray Contrast Agents

Cited by 23 publications

References 20 publications

Nanoparticle contrast agents for computed tomography: a focus on micelles

Nanoparticle contrast agents for computed tomography: a focus on micelles

Syntheses, Structures and Magnetic Properties of New Chalcogen‐Bridged Heterodimetallic Cluster Compounds with Heterocubane Structure

Nanoparticle contrast agents for X‐ray imaging applications

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Cuboidal W3S4 Cluster Complexes as New Generation X-ray Contrast Agents

Cited by 23 publications

References 20 publications

Nanoparticle contrast agents for computed tomography: a focus on micelles

Nanoparticle contrast agents for computed tomography: a focus on micelles

Syntheses, Structures and Magnetic Properties of New Chalcogen‐Bridged Heterodimetallic Cluster Compounds with Heterocubane Structure

Nanoparticle contrast agents for X‐ray imaging applications

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Cuboidal W₃S₄ Cluster Complexes as New Generation X-ray Contrast Agents