Cubosome Based Ion-Selective Optodes–Toward Tunable Biocompatible Sensors

Stelmach, Emilia; Nazaruk, Ewa; Maksymiuk, Krzysztof; Michalska, Agata

doi:10.1021/acs.analchem.1c01247

Cited by 12 publications

(10 citation statements)

References 30 publications

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“…This low response slope and the resulting low precision are important reasons why practical biomedical applications of ion-selective optodes have not been achieved. Indeed, most Ca 2+ optodes exhibit a dynamic range of 3–7 orders of magnitude, − while the plasma Ca 2+ concentration only spans approximately 0.1 and 0.2 order of magnitude for healthy people (2.2–2.6 mM) and asymptotic patients (1.8–3.0 mM), respectively. , The Bakker group proposed an exhaustive response mode of nanoparticle optodes, in which the analyte ions in the sample are depleted in the sensing process due to the efficient extraction of Ca 2+ . , The degree of protonation of the chromoionophore decreases by approximately 50% as Ca 2+ increases from 1 to 15 μM (1.2 orders of magnitude), representing an improved response slope. In contrast, the ChIII in our sensing oil undergoes a 91% change in protonation degree over a Ca 2+ range of only 0.4 order of magnitude (Figure S1), much larger than those of all previous ion-selective optodes.…”

Section: Resultsmentioning

confidence: 99%

Ultrasensitive Ionophore-Based Liquid Sensors for Colorimetric Ion Measurements in Blood

Ghanbari Ghalehjoughi,

Wang,

Kelley

et al. 2023

Anal. Chem.

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The self-monitoring of electrolytes using a small volume of capillary blood is needed for the management of many chronic diseases. Herein, we report an ionophore-based colorimetric sensor for electrolyte measurements in a few microliters of blood. The sensor is a pipet microtip preloaded with a segment of oil (plasticizer) containing a pH-sensitive chromoionophore, a cation exchanger, and an ionophore. The analyte is extracted from the sample into the oil via a mixing protocol controlled by a stepper motor. The oil with an optimized ratio of sensing chemicals shows an unprecedentedly large color response for electrolytes in a very narrow concentration range that is clinically relevant. This ultrahigh sensitivity is based on an exhaustive response mode with a novel mechanism for defining the lower and higher limits of detection. Compared to previous optodes and molecular probes for ions, the proposed platform is especially suitable for at-home blood electrolyte measurements because (1) the oil sensor is interrogated independent of the sample and therefore works for whole blood without requiring plasma separation; (2) the sensor does not need individual calibration as the consistency between liquid sensors is high compared to solid sensors, such as ion-selective electrodes and optodes; and (3) the sensing system consisting of a disposable oil sensor, a programmed stepper motor, and a smartphone is portable, cost-effective, and user-friendly. The accuracy and precision of Ca 2+ sensors are validated in 51 blood samples with varying concentrations of total plasma Ca 2+ . Oil sensors with an ultrasensitive response can also be obtained for other ions, such as K + .

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Section: Resultsmentioning

confidence: 99%

Ultrasensitive Ionophore-Based Liquid Sensors for Colorimetric Ion Measurements in Blood

Ghanbari Ghalehjoughi,

Wang,

Kelley

et al. 2023

Anal. Chem.

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“…1,3,[38][39][40] However, the measurements depend on the concentration of a reference ion such as H + as well as positively charged dyes. [41][42][43][44][45][46][47][48][49][50][51][52][53][54] Secondly, traditional optical sensors generate signals directly in the samples, which could suffer from the color, autoluminescence, and turbidity of the sample. Although sample pretreatment with paper-based devices and hydrogels have been integrated in ion-selective optical sensors, [54][55][56][57][58][59][60][61][62][63][64] complete separation between the sample and detection compartments could overcome potential background optical interference.…”

Section: Converting Electrode Potential To Optical Signalsmentioning

confidence: 99%

Ionophore-based ion-selective electrodes: signal transduction and amplification from potentiometry

2022

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“…Optical sensors benefit from the change of the absorption or emission spectrum in response to a change in analyte concentration in the sample. Regardless of the format of the sensors (polymeric films or nanoparticles in suspension were studied mainly), typically optical sensors require the presence of an optical transducer together with ion-exchanger [1][2][3][4]. Incorporation of analyte into the optical sensor material due to binding results in competition and, ultimately, deprotonation of optical transducer leading to optical signal formation.…”

Section: Introductionmentioning

confidence: 99%

Colorimetric and fluorimetric pH sensing using polydiacetylene embedded within PVC‐PCL nanofibers

et al. 2023

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The applicability of model polydiacetylenes (PDAs) in hydrogen ions sensitive optodes was tested. Nanofibers mats were electrospun using a mixture of polyvinyl chloride (PVC) and polycaprolactone (PCL) together with 10, 12‐tricosadiynoic acid (TCDA) or 10,12‐pentacosadiynoic acid (PCDA). After the polymerization the mats were applied in colorimetric and fluorimetric pH sensors. The PDAs were formed by photopolymerization with a UV lamp (254 nm), resulting in a change of mats color from white to dark blue. The morphology of both fiber mats is similar (SEM images), and the average diameters of fibers were estimated as equal to 228±73 and 248±61 nm for TCDA and PCDA, respectively. As the pH increases, the color of the fiber mat changes from blue to red and the process can be followed visually. The result obtained by computer image analysis showed a sigmoidal increase in the intensity of red and a decrease in the intensity of blue color with increasing pH. A similar sigmoidal response is observed for the dependence of the emission intensity on the pH. Changes in the recorded signal occur in the pH range from 7 to 8.5 or from 8 to 9.5 for mats with TCDA and PCDA, respectively. Both readout modes can be successfully used for pH sensing with proposed nanofibrous mats in the range of pH close to the physiological pH range.

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Cubosome Based Ion-Selective Optodes–Toward Tunable Biocompatible Sensors

Cited by 12 publications

References 30 publications

Ultrasensitive Ionophore-Based Liquid Sensors for Colorimetric Ion Measurements in Blood

Ultrasensitive Ionophore-Based Liquid Sensors for Colorimetric Ion Measurements in Blood

Ionophore-based ion-selective electrodes: signal transduction and amplification from potentiometry

Colorimetric and fluorimetric pH sensing using polydiacetylene embedded within PVC‐PCL nanofibers

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