Flavanones have been prepared by the cyclization of 2'-hydroxychalcones using acidic reagents, such as H 2 SO 4 , HX, CF 3 COOH, CH 3 SO 3 H, KF-celite, or SiO 2 . Treatment of 2'-hydroxychalcones with bases, such as LiOH, KOH, NaOAc, K 2 CO 3 , pyridine, Et 3 N, or N-methylimidazole afforded flavanones. The conversion of 2'-hydroxychalcones to flavanones has been conducted using Co(salpr), K 3 Fe (CN) 6 , CuO, or Ni(Tfacac) 2 . Thioflavanones have been prepared by deprotecting and cyclizing S-protected chalcones using AgNO 3 , HBr, CF 3 COOH, or NaOH and by adding NaSH or KCS 2 OEt to 2'-halochalcones and subsequent substitution. Azaflavanones have been prepared by cyclizing 2'-aminochalcones using acidic reagents, such as H 3 PO 4 , HCl, silica chloride, or K-10 clay. Furthermore, treatment of 2'-aminochalcones with Lewis acids, such as ZnCl 2 , SbCl 3 , Yb(OTf) 3 , InCl 3 , TaBr 5 , or CeCl 3 afforded azaflavanones, and chiral azaflavanones were prepared by cyclizing 2'-aminochalcones in the presence of per-6-ABCD, chiral amine, BINOL-phosphoric acid, or thiourea catalyst.