Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats

Kaur, Anudeep; Kaur, Tajpreet; Singh, Balbir; Pathak, Devendra; Buttar, Harpal S.; Singh, Amrit Pal

doi:10.1080/0886022x.2016.1214892

Cited by 34 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rats were randomly equally divided into three groups ( n = 10 for each group): I/R-Curcumin group (Cur) in which the rats were subjected to renal ischemia for 45 min and precondition with 60 mg/kg (i.p. injection) of Curcumin (Sigma, St. Louis, MO) at 45 min before I/R induction; The dosage of Curcumin was in line with previous study [ 7 ]. I/R-vehicle group (IRI), in which the rats were subjected to renal ischemia for 45 min and precondition with 60 mg/kg (i.p.…”

Section: Methodssupporting

confidence: 55%

See 1 more Smart Citation

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats

Zhang

Tang

et al. 2018

Renal Failure

View full text Add to dashboard Cite

The present study aimed to explore the protective mechanism of curcumin-precondition in renal ischemia-reperfusion (I/R) injury. Thirty male SD rats were randomly equally divided into Sham, IRI, and Curcumin groups (n = 10). The model of IRI was induced by clamping the left renal artery for 45 min followed by 24 h reperfusion with the contralateral nephrectomy. ELISA was used to examine the expression of Cr, BUN, IL-8, TNF-α, and IL-6 in the serum; RT-PCR was used to detect the mRNA level of IL-8,TNF-α, and IL-6 in the kidney; The morphology of kidney was examined by Periodic Acid-Schiff stain (PAS). The expression of JAK2, p-JAK2, STAT3, p-STAT3, p65, and p-p65 in kidney were detected by Western blotting. The result displayed that Curcumin pretreatment can significantly increase the expression of p-JAK2 and p-STAT3 and reduce the expression of Cr, BUN, IL-8, TNF-α, IL-6, and p-p65. In addition, Curcumin can attenuate the kidney pathological injury and have no effect on the expression of JAK2, STAT3, and p65. Our findings showed the protective effect of Curcumin in I/R injury is associated with suppressing NF-κB mediating inflammation by activating JAK2/STAT3 signal pathway.

show abstract

Section: Methodssupporting

confidence: 55%

“…I/R-Curcumin group (Cur) in which the rats were subjected to renal ischemia for 45 min and precondition with 60 mg/kg (i.p. injection) of Curcumin (Sigma, St. Louis, MO) at 45 min before I/R induction; The dosage of Curcumin was in line with previous study [ 7 ].…”

Section: Methodssupporting

confidence: 55%

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats

Zhang

Tang

et al. 2018

Renal Failure

View full text Add to dashboard Cite

show abstract

“…In fact, many recent studies have also shown that curcumin may relieve damage due to AKI. Kaur et al () demonstrated that NMDA receptor antagonism significantly contributes to curcumin‐mediated protection against I/R‐induced AKI. He et al () clearly demonstrated that curcumin protects the kidney from gentamicin‐induced AKI via the amelioration of oxidative stress and apoptosis of renal tubular cells.…”

Section: Discussionmentioning

confidence: 99%

Curcumin alleviates ischemia reperfusion‐induced late kidney fibrosis through the APPL1/Akt signaling pathway

Chen

Fan

Huang

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

As a major cause of renal failure, transient renal ischemia and reperfusion induce both acute kidney injury and late fibrosis, which are the common pathological manifestations of end-stage renal disease. Curcumin is a biologically active polyphenolic compound found in turmeric. Increasing evidence has demonstrated that curcumin has a protective action against renal fibrosis, whereas mechanisms underlying the anti-fibrosis role of curcumin remain poorly defined. Here, we found that APPL1, an important intracellular binding partner for AdipoR, was involved in the pathogenesis of acute injury or fibrosis and was significantly upregulated by curcumin in a mouse model of ischemia reperfusion-induced late kidney fibrosis. Moreover, Akt signaling was the specific signaling pathway identified downstream of APPL1 in the pathogenesis of fibrosis. Our in vitro experiment demonstrated that curcumin alleviates ischemia reperfusion-induced late kidney fibrosis via the APPL1/Akt pathway. These data are helpful for understanding the anti-fibrosis mechanism of curcumin in the pathogenesis of AKI-induced late fibrosis.

show abstract

“…Besides, A. Kaur et al (2016) speculated that curcumin is an NMDA receptor antagonist. Curcumin could also reverse the glutamate-induced excitotoxicity in the (a) cerebral cortex region of streptozotocin-induced diabetic rats (Jayanarayanan, Smijin, Peeyush, Anju, & Paulose, 2013), (b) PC12 cells (Chang, Chen, Yu, Peng, & Peng, 2014), and (c) SH-SY 5Y neuronal differentiated cell culture (Chen, An, Tie, Pan, & Li, 2015).…”

Section: Gabaergic and Glutamatergic Modulation By Curcuminmentioning

confidence: 99%

Curcumin in epilepsy disorders

Dhir

2018

Phytotherapy Research

View full text Add to dashboard Cite

Curcumin, a principal curcuminoid present in turmeric, has an antioxidant, anti-inflammatory and neuroprotective properties. Preclinical studies have indicated its beneficial effect for the treatment of epilepsy disorders. The molecule has an anti-seizure potential in preclinical studies, including chemical and electrical models of acute and chronic epilepsy. Curcumin also possesses an anti-epileptogenic activity as it reduces spontaneous recurrent seizures severity in a kainate model of temporal lobe epilepsy. The antioxidant and anti-inflammatory nature of curcumin might be responsible for its observed anti-seizure effects; nevertheless, the exact mechanism is not yet clear. The poor availability of curcumin to the brain limits its use in clinics. The application of nanoliposome and liposome technologies has been tested to enhance its brain availability and penetrability. Unfortunately, there are no randomized, double-blinded controlled clinical trials validating the use of curcumin in epilepsy. The present article analyzes different preclinical evidence illustrating the effect of curcumin in seizure models. The review encourages carrying out clinical trials in this important area of research. In conclusion, curcumin might be beneficial in patients with epilepsy disorders, if its bioavailability issues are resolved.

show abstract

Curcumin alleviates ischemia reperfusion-induced acute kidney injury through NMDA receptor antagonism in rats

Abstract: It is concluded that NMDA receptor antagonism significantly contributes towards curcumin-mediated protection against I/R-induced AKI.

Cited by 34 publications

References 21 publications

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats

Curcumin alleviates ischemia reperfusion‐induced late kidney fibrosis through the APPL1/Akt signaling pathway

Curcumin in epilepsy disorders

Contact Info

Product

Resources

About