Curcumin Benefits as Antioxidant, Antiinflamation and Antiapoptosis Ameliorate Paracetamol Toxicity

Abstract

Background: Paracetamol poisoning due to the use of paracetamol overdose is the most prevalent case of poisoning. Toxic metabolites from paracetamol cause glutathione depletion and lead to hepatic cell death. Curcumin, a polyphenol substrat in Curcuma longa, has been known to ameliorate the toxic effects of paracetamol. The mechanisms have been known are curcumin as antioxidant, anti-inflammatory, and anti-apoptotic. The curcumin protection mechanism against paracetamol poisoning will be discussed.Methods: The journal’s search for the protective effects of curcumin on paracetamol toxicity is derived from PubMed database using keyword curcumin and acetaminophen. Research on experimental animals is as the limits of the study subjects of the journal search.Result: From a search in PubMed database, there are 15 journal titles discussing the effects of curcumin protection against paracetamol toxicity, and 11 journals selected that correspond to the research topic. Of the 11 journals selected, concluded that curcumin was found to prevent worsening of paracetamol toxicity by increasing antioxidant activity and decreasing inflammation and apoptotic.Conclusion: Curcumin has the potential benefit to be used as a medical therapeutic for the prevention and treatment of paracetamol toxicity.

Beyond Conventional Treatment: Exploring Natural Therapies for Paracetamol Overdose

“…As the toxicity progresses, jaundice, coagulopathy, encephalopathy, and multi-organ failure may develop (7) . Chronic ingestion of supra-therapeutic doses can cause a subacute form of liver injury that may present with nonspecific symptoms, such as fatigue and malaise, and can progress to cirrhosis, end-stage liver disease, and kidney failure as well (12) . Laboratory findings that support the diagnosis of paracetamol toxicity include elevated transaminases (AST and ALT), bilirubin, prothrombin time, and declining bicarbonate (7) .…”

“…This process allows for the replenishment of hepatic glutathione stores and the scavenging of reactive oxygen species (7) . NAC can be administered orally or intravenously, with the intravenous route being preferred in patients with severe toxicity or compromised oral intake (12) .…”

“…Turmeric is an herbaceous and aromatic plant that belongs to the Zingiberaceae family (44) . Curcumin is a polyphenol found in the yellow flowers of turmeric grown in China and India (12) . Traditionally, curcumin has been used for liver disorders (13) .…”

Studies on Bioavailability Enhancement of Curcumin

“…(Family: Zingiberaceae) has potential in the prevention and therapeutic interventions of several pathological conditions including respiratory diseases, inflammation, liver disorders and diabetic wounds. It prevents a variety of carcinogen-induced cancers in rodents by suppressing the mutagenic effects of carcinogens [1]. In addition, the hepato-and nephroprotective, thrombosis suppressing, myocardial infarction protective, hypoglycemic, and antirheumatic effects of curcumin are also reported [2][3][4].…”

Elsayed A Usage and Knowledge of the Over- the- Counter Medicines Among Patient Visiting Ophthalmic Hospital in Wad Medani, Sudan

“…Failure to comply with directions may lead to serious side effect (i.e., the correct dose, correct schedule, and for the intended disease). For example, overdose of acetaminophen has been associated with liver damage [1]. Analgesics increase the gastrointestinal tract bleeding even when taken at appropriate doses [2].…”