Curcumin induces thermotolerance by reducing oxidative stress, apoptosis, and inflammation in buffalo mammary epithelial cells under heat shock conditions

Grewal, Sonika; Aggarwal, Anjali; Vats, Preeti; Rani, S. Indira; Jaswal, Shalini; Pal, Prasanna; Senthamilan, S.; Arya, Ashwani; Mohanty, A. K.; Alhussien, Mohanned Naif

doi:10.1016/j.jri.2022.103684

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…Moreover, Grewal et al [ 61 ] demonstrated that in vitro heat shock in buffalo mammary epithelial cells (BuMECs) led to distorted morphology, abnormal cell shape, and loss of cell–cell contact, along with a decrease in cell viability and proliferation. To address this issue, curcumin was added at different concentrations.…”

Section: Curcumin In Stress Management Of Terrestrial Animalsmentioning

confidence: 99%

“…Interestingly, the results showed that lower concentrations of curcumin (5 and 10 μM) provided better alleviation of the harmful effects of heat stress on the epithelial cells compared to higher-concentration groups. This was evidenced by the enhanced expression of heat-shock proteins, antioxidant genes, and anti-apoptotic genes [ 61 ] ( Table 2 ).…”

Section: Curcumin In Stress Management Of Terrestrial Animalsmentioning

confidence: 99%

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Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review

Tuong,

Moniruzzaman,

Smirnova

et al. 2023

Antioxidants

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Stress has brought about a variety of harmful impacts on different animals, leading to difficulties in the management of animal husbandry and aquaculture. Curcumin has been recognized as a potential component to ameliorate the adverse influence of animal stress induced by toxicity, inflammation, diseases, thermal effect, and so on. In detail, this compound is known to offer various outstanding functions, including antibacterial properties, antioxidant effects, immune response recovery, and behavioral restoration of animals under stress conditions. However, curcumin still has some limitations, owing to its low bioavailability. This review summarizes the latest updates on the regulatory effects of curcumin in terms of stress management in terrestrial, avian, and aquatic animals.

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Section: Curcumin In Stress Management Of Terrestrial Animalsmentioning

confidence: 99%

Section: Curcumin In Stress Management Of Terrestrial Animalsmentioning

confidence: 99%

Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review

Tuong,

Moniruzzaman,

Smirnova

et al. 2023

Antioxidants

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show abstract

“…Curcumin exhibits potent antiapoptotic, anti-inflammatory, and antioxidant activity. 14 Members of the apoptotic/antiapoptotic Bcl-2 (B-cell lymphoma 2) family were implicated in the drug-resistant characteristics of several cancers. The Bcl-2 family of proteins and a class of cysteine proteases called caspases are two major protein groups crucial in apoptotic cell death.…”

Section: Introductionmentioning

confidence: 99%

Curcumin nanocapsules effect in apoptotic processes, gene expression, and cell cycle on Hep-G2 cell lines

Moawad

Nasr

Osman

et al. 2023

Int J Immunopathol Pharmacol

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Objectives Curcumin has antioxidant and antiproliferative properties, and its therapeutic effect must be considered. Nanocurcumin capsules showed a potential increase against in vitro biological cancer. This study sought to determine how curcumin nanoparticles and nanocapsules affected the expression of p53, Bcl-2, Bax, and Bax in a liver cancer cell line (Hep-G2). Mechanisms of apoptosis were also examined in this cell line. Methods This study used quantitative real-time polymerase chain reaction (qRT-PCR) to analyze the p53, Bcl-2, Bax, and Caspase-3 gene pathways and to evaluate the molecular mechanisms responsible for the efficacy of curcumin nanoparticles (CNPs) and curcumin nanocapsules (CNCs) against liver cell lines. Flow cytometry was used to check for signs of apoptosis and the cell cycle. Results Curcumin nanocapsules produced by the ball milling process at 90 min significantly boosted the populations of apoptotic cells in a dose- and time-dependent manner. The mRNA expression analysis revealed that the proapoptotic Bax, Caspase-3, and the tumor suppressor gene p53 were upregulated throughout the process started by curcumin nanocapsules and decreased in the Bcl-2/Bax ratio . Conclusion This research provides a fresh understanding of the molecular mechanisms behind the liver cancer-fighting abilities of curcumin nanoparticles. Curcumin nanocapsules produced through a unique mechanical technique can be used as an anticancer agent.

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Pre-treatment but not co-treatment with vitexin alleviates hyperthermia induced oxidative stress and inflammation in buffalo mammary epithelial cells

Senthamilan

Aggarwal

Grewal

et al. 2023

Journal of Reproductive Immunology

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Curcumin induces thermotolerance by reducing oxidative stress, apoptosis, and inflammation in buffalo mammary epithelial cells under heat shock conditions

Cited by 4 publications

References 54 publications

Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review

Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review

Curcumin nanocapsules effect in apoptotic processes, gene expression, and cell cycle on Hep-G2 cell lines

Pre-treatment but not co-treatment with vitexin alleviates hyperthermia induced oxidative stress and inflammation in buffalo mammary epithelial cells

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