Curcumin loaded polymeric micelles of variable hydrophobic lengths by RAFT polymerization: Preparation and in-vitro characterization

The metabolomic analysis of five Mentha species: cytotoxicity, anti-Helicobacter assessment, and the development of polymeric micelles for enhancing the anti-Helicobacter activity

“…[22][23][24] Nanoparticles enhance formulation parameters and improve the therapeutic potential of hydrophobic drugs. [25][26][27] Pluronic® F127 is a biodegradable and biocompatible polymer that is used successfully to develop nanoscale polymeric micelles. The polymer promotes the drug encapsulation, permeation and therapeutic potential of various drugs [28][29][30][31] The conventional use of Mentha species for the treatment of gastrointestinal symptoms and its inclusion in German Commission E lists for treatment of gastrointestinal disorders, 32 in most cases without identication of phenotypic plasticity and genetic variability because of extensive hybridization, triggered our interest in comparing the chemical proles of ve Mentha species cultivated in Egypt: M. suaveolens, M. sylvestris, Mentha  piperita, M. longifolia, and M. viridis.…”

Simple Strategy Preparing Cyclodextrin Carboxylate as a Highly Effective Carrier for Bioactive Compounds

“…The encapsulation of curcumin in the Cur-SACD complexes kept on increasing at relatively low total curcumin levels (50–200 μL) (Figure E), suggesting that the majority of curcumin was located within the hydrophobic cavities of the SACD molecules. Other researchers have reported that a high dose of curcumin could also be solubilized in polymer micelles . Zhi et al prepared modified starch with hydroxypropylation and debranching, and the obtained derivative was further used to prepare nanosized micelles for curcumin encapsulation.…”

“…Other researchers have reported that a high dose of curcumin could also be solubilized in polymer micelles. 40 Zhi et al 41 prepared modified starch with hydroxypropylation and debranching, and the obtained derivative was further used to prepare nanosized micelles for curcumin encapsulation. The complexation system displayed superior cellular and blood safety; meanwhile, significantly enhanced solubility and photo and thermal stability of curcumin were realized.…”

Poly(2‐(dimethylamino) ethyl methacrylate)‐b‐poly(lauryl methacrylate)‐b‐poly(oligo ethylene glycol methacrylate) triblock terpolymer micelles as drug delivery carriers for curcumin

“…All the above make CUR an ideal model compound candidate for studying its potential encapsulation and delivery with novel polymeric micelles systems. [13][14][15][16][17] Several block copolymer systems, including ABA-type triblocks, 18 have been reported as nanocarriers for the delivery of CUR, [19][20][21] however, limited research has been published as far as ABC triblock terpolymers are concerned. 22 ABC-type triblock terpolymers consist of three blocks with different properties and exhibit increased structural complexity compared with conventional diblock copolymers.…”

“…However, CUR presents poor solubility in aqueous media, as well low chemical stability in the body fluids, 12 therefore an external drug delivery vehicle is needed for its effective delivery. All the above make CUR an ideal model compound candidate for studying its potential encapsulation and delivery with novel polymeric micelles systems 13–17 . Several block copolymer systems, including ABA‐type triblocks, 18 have been reported as nanocarriers for the delivery of CUR, 19–21 however, limited research has been published as far as ABC triblock terpolymers are concerned 22 …”