Curcumin sensitizes carboplatin treatment in triple negative breast cancer through reactive oxygen species induced DNA repair pathway

Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review

“…Treatment with curcumin also increased ROS production in colorectal cancer SW480 cells [ 52 ]. Additionally, curcumin treatment could enhance ROS levels in breast cancer MDA-MB-231 cells [ 24 ]. Curcumin-induced ROS upregulation also triggered endoplasmic reticulum stress in prostate cancer-associated fibroblasts via the PERK-eIF2α-ATF4 axis, ultimately leading to apoptosis [ 74 ].…”

“…Curcumin has shown anticancer effects on various cancers, such as breast, liver, lung, gastric and prostate cancers. For example, curcumin inhibited breast cancer MDA-MB-231 cells proliferation and induced apoptosis by increasing reactive oxygen species (ROS) production [ 24 ]. Curcumin also inhibited liver cancer HepG2 cells‘ proliferation, invasion and metastasis through inhibiting heat shock protein 70 (HSP70)- toll-like receptor 4 (TLR4) signaling [ 25 ].…”

Simulate the Dynamic Interactions Across Nutritional Supplements, the Polybiome, and the Biochemical Approach Dependent on Patient-Derived Gastrointestinal Knowledge

“…Furthermore, when Choy and his colleagues studied the feces of pigs given polymeric proanthocyanidins, they reported that only 10% of the polymeric pro-anthocyanidins had been identified [128][129][130][131][132][133][134][135]. When proanthocyanidins are broken down, it has been demonstrated that they have a positive influence on the development of cancers [136][137][138][139][140][141]. An anti-inflammatory drug is made by combining polyphenolic compounds with Curcuma longa [142][143][144][145].…”

Smart Nanoparticles for Breast Cancer Treatment Based on the Tumor Microenvironment

“…From the perspective of cancer, the conventional view that ROS cause widespread damage and chaos within cells has long been debated in the scientific community (63)(64)(65). Recently, great progress has been made in the understanding of ROS biology, and there is increasing evidence that the effects of ROS are gradient-dependent, with a threshold of habituation, which affects their signal transduction and toxicity induction function, thus resulting in either "good" or "bad" ROS (33).…”

“…Recently, great progress has been made in the understanding of ROS biology, and there is increasing evidence that the effects of ROS are gradient-dependent, with a threshold of habituation, which affects their signal transduction and toxicity induction function, thus resulting in either "good" or "bad" ROS (33). For example, ROS play a key role in the activation of tumor-promoting signaling pathways (64,66,67). Moreover, abnormal production of ROS and ineffective neutralization of excessive ROS levels can lead to tumor growth and progression through different signaling pathways, including phosphatidylinositol 3kinase/protein kinase inhibitor/mammalian target of rapamycin (PI3/Akt/mTOR), vascular endothelial growth factor (VEGF)/ VEGF receptor, phosphatase and tensin congeners (PTEN), and matrix metalloproteinase (MMP) pathways (68).…”